Servicios deportivos para promover el turismo sostenible. Revisión de la literatura.

Sustainable tourism has get strength, becoming a topic of global interest, where the preservation of resources and healthy lifestyles play an important role to guarantee the future of generations.   The purpose of the report is to present the relationship between sport and nature as a strategy to promote sustainable tourism focusing mainly on the offer of sports that can be practiced in natural environments considering the potential of the ecological resources of the department of Atlántico.  Within the bibliographic review, multiple publications were evidenced that by means of a characterization, 75 articles were chosen, these being refined under some acceptance criteria, selecting 20% ​​of the total, as they were the ones with the greatest contribution to the research objective. Likewise, a scientometric analysis of the search results was carried out based on key terms such as “sustainable tourims AND sports”. The results show that in last years , the tourism sector has had its greatest growth, and that it has also favored the economy and cultural values of the regions where it is developed. Associating sports and nature is increasingly common, however, it could affect the sustainabilityof natural resources. The conclusion obtained from this information is that sports and tourism practices in nature are an investment that generates benefits such as increased employment, economic diversification, business creation, cultural development, among others; However, they can also affect the biodiversity and natural resources of the region, so it is important to take the necessary preventive measures and involve government entities, the community and tourists.El turismo sostenible ha cobrado fuerza convirtiéndose en un tema de interés mundial, en el cual la preservación de los recursos y los hábitos de vida saludable juegan un papel importante para garantizar el futuro de las generaciones.  El presente documento tiene como propósito plantear la relación entre el deporte y la naturaleza como una estrategia para promover el turismo sostenible, enfocándose principalmente en la oferta de deportes que se pueden practicar en ambientes naturales considerando el potencial de los recursos ecológicos del departamento del Atlántico.  Dentro de la revisión bibliográfica se evidenciaron múltiples publicaciones que por medio de una caracterización se eligieron 75 artículos siendo estos depurados bajo unos criterios de aceptación, seleccionando el 20% del total, por ser los de mayor aporte para el objetivo de investigación. Así mismo se efectuó un análisis cienciométrico de los resultados de búsqueda basada en términos claves como “sustainable tourims AND sports”. Los resultados muestran que en los últimos años el sector turístico ha tenido su mayor crecimiento, y que además ha favorecido la economía y los valores culturales de las regiones donde se desarrolla. Asociar deportes y naturaleza es cada vez más común, no obstante, podría afectar la preservación de los recursos naturales.  Para concluir, las prácticas de deporte y turismo en la naturaleza resultan una inversión que favorece el incremento de empleo, la diversificación económica, la creación de empresas, el desarrollo cultural, entre otras; sin embargo, también pueden afectar la biodiversidad y los recursos naturales de la región, por ello es importante tomar las medidas preventivas necesarias e involucrar a las entidades gubernamentales, la comunidad y los turistas

Analysis of protein-coding genetic variation in 60,706 humans

Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. We describe the aggregation and analysis of high-quality exome (protein-coding region) sequence data for 60,706 individuals of diverse ethnicities generated as part of the Exome Aggregation Consortium (ExAC). This catalogue of human genetic diversity contains an average of one variant every eight bases of the exome, and provides direct evidence for the presence of widespread mutational recurrence. We have used this catalogue to calculate objective metrics of pathogenicity for sequence variants, and to identify genes subject to strong selection against various classes of mutation; identifying 3,230 genes with near-complete depletion of truncating variants with 72% having no currently established human disease phenotype. Finally, we demonstrate that these data can be used for the efficient filtering of candidate disease-causing variants, and for the discovery of human “knockout” variants in protein-coding genes

Servicios deportivos para promover el turismo sostenible. Revisión de la literatura.

Sustainable tourism has get strength, becoming a topic of global interest, where the preservation of resources and healthy lifestyles play an important role to guarantee the future of generations.   The purpose of the report is to present the relationship between sport and nature as a strategy to promote sustainable tourism focusing mainly on the offer of sports that can be practiced in natural environments considering the potential of the ecological resources of the department of Atlántico.  Within the bibliographic review, multiple publications were evidenced that by means of a characterization, 75 articles were chosen, these being refined under some acceptance criteria, selecting 20% ​​of the total, as they were the ones with the greatest contribution to the research objective. Likewise, a scientometric analysis of the search results was carried out based on key terms such as “sustainable tourims AND sports”. The results show that in last years , the tourism sector has had its greatest growth, and that it has also favored the economy and cultural values of the regions where it is developed. Associating sports and nature is increasingly common, however, it could affect the sustainabilityof natural resources. The conclusion obtained from this information is that sports and tourism practices in nature are an investment that generates benefits such as increased employment, economic diversification, business creation, cultural development, among others; However, they can also affect the biodiversity and natural resources of the region, so it is important to take the necessary preventive measures and involve government entities, the community and tourists.El turismo sostenible ha cobrado fuerza convirtiéndose en un tema de interés mundial, en el cual la preservación de los recursos y los hábitos de vida saludable juegan un papel importante para garantizar el futuro de las generaciones.  El presente documento tiene como propósito plantear la relación entre el deporte y la naturaleza como una estrategia para promover el turismo sostenible, enfocándose principalmente en la oferta de deportes que se pueden practicar en ambientes naturales considerando el potencial de los recursos ecológicos del departamento del Atlántico.  Dentro de la revisión bibliográfica se evidenciaron múltiples publicaciones que por medio de una caracterización se eligieron 75 artículos siendo estos depurados bajo unos criterios de aceptación, seleccionando el 20% del total, por ser los de mayor aporte para el objetivo de investigación. Así mismo se efectuó un análisis cienciométrico de los resultados de búsqueda basada en términos claves como “sustainable tourims AND sports”. Los resultados muestran que en los últimos años el sector turístico ha tenido su mayor crecimiento, y que además ha favorecido la economía y los valores culturales de las regiones donde se desarrolla. Asociar deportes y naturaleza es cada vez más común, no obstante, podría afectar la preservación de los recursos naturales.  Para concluir, las prácticas de deporte y turismo en la naturaleza resultan una inversión que favorece el incremento de empleo, la diversificación económica, la creación de empresas, el desarrollo cultural, entre otras; sin embargo, también pueden afectar la biodiversidad y los recursos naturales de la región, por ello es importante tomar las medidas preventivas necesarias e involucrar a las entidades gubernamentales, la comunidad y los turistas

3er. Coloquio: Fortalecimiento de los Colectivos de Docencia

Las memorias del 3er. Coloquio de Fortalecimiento de Colectivos de Docencia deben ser entendidas como un esfuerzo colectivo de la comunidad de académicos de la División de Ciencias y Artes para el Diseño, en medio de la pandemia COVID-19, con el fin de: • Analizar y proponer acciones concretas que promuevan el mejoramiento de la calidad docente en la División. • Proponer acciones que permitan continuar fortaleciendo los cursos con modalidad a distancia (remotos). • Ante un escenario que probablemente demandará en el mediano plazo, transitar del modelo remoto a un modelo híbrido, proponer acciones a considerar para la transición de los cursos. • Planear y preparar cursos de nivelación de conocimientos, para cuando se transite a la impartición de la docencia de manera mixta o presencial, dirigidos a los alumnos que no hayan tenido oportunidad de desarrollar actividades relevantes para su formación, como prácticas de talleres y laboratorios, visitas, o alguna otra actividad relevante

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano

Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele