76 research outputs found
Evaluación de resultados en psicoterapia breve ericksoniana : aplicación del OQ-45.2 en una muestra de pacientes ambulatorios de la Ciudad de Mendoza
El presente trabajo tiene como objetivo, el medir la efectividad de procesos psicoterapéuticos y observar en qué momento del proceso se produce la mayor incidencia de cambios, en el marco del enfoque de psicoterapia breve con orientación ericksoniana.
Se trata de una investigación cuantitativa con un diseño longitudinal de panel. Se trabajó en el seguimiento de veinticuatro (24) procesos psicoterapéuticos llevados a cabo en el Consultorio Abierto a la Comunidad de la Fundación Puentes de Cambio de la Provincia de Mendoza, bajo el consentimiento informado de los participantes. Se utilizó el instrumento de medición de resultados “Outcome Questionnaire” OQ-45.2 (Lambert, 1996; Adaptación y Validación Von Bergen y De la Parra, 2002), administrado en la primera sesión y luego cada 4 sesiones.
Como conclusión, se observó que en un 75% de los casos evaluados, la psicoterapia con orientación ericksoniana, resultó ser efectiva; y el momento de cambios clínicamente significativos (CCS) de mayor incidencia se produce entre la sesión N° 4 y la sesión N° 8; resultando entonces, este instrumento, idóneo para los fines de la investigación propuesta.This paper aims to measure the psychotherapeutic processes effectiveness, and observe at what point in the process the higher incidence of changes occurs, under the Ericksonian Brief Therapy Approach.
This work is a quantitative research with a longitudinal panel design. It was carried out monitoring twenty-four (24) psychotherapeutic processes conducted in the Community Open Clinic to the Bridges of Change Foundation in Mendoza Province, under the informed consent of participants. The measuring results method "Outcome Questionnaire" OQ-45.2 (Lambert, 1996, Adaptation and Validation Von Bergen y De la Parra, 2002), administered in the first session and then every 4 sessions was used.
In conclusion, it was observed that the Ericksonian Brief Therapy proved effective in 75% of the evaluated cases; and Clinically Significant Change (CCS) with the highest incidence occurs between Session N° 4 and Session N° 8,resulting this instrument ideal for the purposes of the proposed research.Fil: Sánchez, Noelia Carolin
Caracoles conoideos de aguas profundas argentinas
A partir de muestreos en aguas profundas estudiamos los conoideos de la Argentina, un grupo de caracoles marinos, cazadores, extremadamente diversos, distribuidos en todos los océanos, latitudes y profundidades. Estudiamos material de las colecciones malacológicas locales y aquel proveniente de las campañas realizadas al Cañón Submarino de Mar del Plata y al Banco Burdwood y zonas aledañas. Se presentan los resultados ya publicados de los géneros Aforia y Theta y otros en proceso como Leucosyrinx. El conocimiento de la fauna de conoideos de aguas profundas de la Argentina contribuirá a establecer el origen de los grupos de moluscos sudamericanos.Fil: Sánchez, Noelia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentin
New taxonomic position and neotype designation for the conoidean gastropod Pleurotoma patagonica d’Orbigny, 1841
Pleurotoma patagonica d’Orbigny, 1841 has been placed in several genera and families since its original description, perhaps because the type material, presumed lost, was never revised after the original description and because of the chaotic systematics of conoidean gastropods. New specimens, matching the original description and illustration and collected near the type locality allowed us to study the radula, shell, and protoconch. A neotype designation is proposed for this species in order to fix its identity. We tentatively assign it to the mangeliid genus Bela Leach, 1847, thus establishing Bela pata-gonica (d’Orbigny, 1841) comb. nov. Eleven species of Bela have been reported from Argentine waters; however, all of them have been reclassified into other genera and even other families. Despite the appar-ent geographic distance of B. patagonica comb. nov. from other species of this genus, this taxonomic placement of this species seems most appropriate and emphasizes shell characters until molecular data become available.Fil: Sánchez, Noelia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Pastorino, Roberto Santiago Guido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentin
Programa de terapia ocupacional para personas con demencia en un centro de día
Este trabajo tiene como objetivo central realizar un programa desde terapia ocupacional en un centro de día dirigido a personas con demencia y a sus cuidadores, realizado con el fin de poder actuar sobre las necesidades que presenta la población actual, cada vez más envejecida y con diversas enfermedades asociadas, una de las cuales es la demencia. Para realizar el programa se utiliza un modelo propio de Terapia Ocupacional, el Modelo de Discapacidad Cognitiva de Allen y se utilizan una serie de escalas estandarizadas, a su vez se tienen en cuenta distintos factores como: las características y los distintos tipos de demencia que se pueden encontrar, las necesidades que presentan tanto los enfermos como sus cuidadores, etc. A partir de esto se plantean unos objetivos que cubran las necesidades de ambos grupos con el fin de poder mejorar la calidad de vida de dichos pacientes. Tras plantear los objetivos se plasman unas ideas generales para poder llevar a cabo de forma adecuada el programa. Para tener un mayor control del programa se realizaran evaluaciones de forma periódica tanto a usuarios como a cuidadores
Anion–Cation Recognition Pattern, Thermal Stability and DFT-Calculations in the Crystal Structure of H2dap[Cd(HEDTA)(H2O)] Salt (H2dap = H2(N3,N7)-2,6-Diaminopurinium Cation)
We thank the Centre de Tecnologies de la Informació (CTI), Universitat de les Illes Balears for
computational facilities. We also thank all projects for financial support.The proton transfer between equimolar amounts of [Cd(H2EDTA)(H2O)] and
2,6-diaminopurine (Hdap) yielded crystals of the out-of-sphere metal complex H2(N3,N7)dap
[Cd(HEDTA)(H2O)]·H2O (1) that was studied by single-crystal X-ray diffraction, thermogravimetry,
FT-IR spectroscopy, density functional theory (DFT) and quantum theory of “atoms-in-molecules”
(QTAIM) methods. The crystal was mainly dominated by H-bonds, favored by the observed tautomer
of the 2,6-diaminopurinium(1+) cation. Each chelate anion was H-bonded to three neighboring
cations; two of them were also connected by a symmetry-related anti-parallel π,π-staking interaction.
Our results are in clear contrast with that previously reported for H2(N1,N9)ade [Cu(HEDTA)
(H2O)]·2H2O (EGOWIG in Cambridge Structural Database (CSD), Hade = adenine), in which H-bonds
and π,π-stacking played relevant roles in the anion–cation interaction and the recognition between
two pairs of ions, respectively. Factors contributing in such remarkable differences are discussed on
the basis of the additional presence of the exocyclic 2-amino group in 2,6-diaminopurinium(1+) ion.This research was funded by the Excellence Network ‘Metal Ions in Biological Systems’ MetalBio
CTQ2017-90802-REDT, the Research group FQM-283 (Junta de Andalucía) and MICIU/AEI of Spain (project
CTQ2017-85821-R FEDER funds)
Characterization of CD34+ hematopoietic cells in systemic mastocytosis: Potential role in disease dissemination
[Background]: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs−), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM and identified the specific PB cell compartments that carry this mutation.
[Methods]: The distribution of different maturation-associated subsets of BM and PB CD34+ HPC from 64 newly diagnosed (KIT-mutated) ISM patients and 14 healthy controls was analyzed by flow cytometry. In 18 patients, distinct FACS-purified PB cell compartments were also investigated for the KIT mutation.
[Results]: ISM patients showed higher percentages of both BM and PB MC-committed CD34+ HPC vs controls, particularly among ISM cases with MC-restricted KIT mutation (ISMMC); this was associated with progressive blockade of maturation of CD34+ HPC to the neutrophil lineage from ISMMC to multilineage KIT-mutated cases (ISMML). Regarding the frequency of KIT-mutated cases and cell populations in PB, variable patterns were observed, the percentage of KIT-mutated PB CD34+ HPC, eosinophils, neutrophils, monocytes and T cells increasing from ISMs−MC and ISMs+MC to ISMML patients.
[Conclusion]: The presence of the KIT D816V mutation in PB of ISM patients is associated with (early) involvement of circulating CD34+ HPC and multiple myeloid cell subpopulations, KIT-mutated PB CD34+ HPC potentially contributing to early dissemination of the disease.This work was supported by Fondo de Investigaciones Sanitarias—FIS—of the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain (grant numbers PI11/02399 and PI16/00642, FEDER); Consejería de Educación (Regional Government of Castilla y León, Spain; grant number SA013U16); Biomedical Research Networking Centre Consortium–CIBER-CIBERONC (CB16/12/00400) of the Instituto de Salud Carlos III, Madrid, Spain; and Fundacion Ramon Areces, Madrid, Spain (grant CIVP16A1806). AM was supported by a RTICC (Red Tematica de Investigacion Cooperativa en Cancer) grant (RD12/0036/0048, FIS, FEDER)
Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
Background: Type 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype
of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The antiproliferative effect of somatostatin analogues (SSA) is well known, and their action on GC-1s has been postulated as a chronic treatment to reduce recurrence.
Methods: A two-centered, retrospective, observational study that included nine patients (55.6% women) diagnosed with GC-1, receiving long-term treatment with SSA, with a median follow-up from baseline of 22 months, was undertaken. Endoscopic follow-up, extension study, and analytical values of chromogranin A (Cg A) and gastrin were collected. Results: In total, 88.9% of patients presented partial or complete response. Treatment with SSA was the only independent factor with a trend to prevent tumor recurrence (Odds Ratio 0.054; p = 0.005). A nonsignificant tendency toward a decrease in CgA and gastrin was observed; lack of significance was probably related to concomitant
treatment with proton pump inhibitors in some patients. Conclusions: Chronic treatment with SSA is a feasible option for recurrent GC-1s that are difficult to manage using endoscopy or gastrectomy. Randomized clinical trials to provide more scientific evidence are still neede
A Telehealth-Based Cognitive-Adaptive Training (e-OTCAT) to Prevent Cancer and Chemotherapy-Related Cognitive Impairment in Women with Breast Cancer: Protocol for a Randomized Controlled Trial
Background: Many women with breast cancer experience a great number of side effects,
such as cognitive impairment, during and after chemotherapy that reduces their quality of life. Currently,
research focusing on the use of non-pharmacological, and specifically telehealth interventions
to prevent or mitigate them has been insufficient. Methods: This protocol describes a randomized
controlled trial aimed at studying the preventive effects of a videoconferenced cognitive-adaptive
training (e-OTCAT) program (ClinicalTrials.gov NCT04783402). A number of 98 eligible participants
will be randomized to one of the following groups: (a) the experimental group receiving the e-OTCAT
program during 12 consecutive weeks since the beginning of chemotherapy; and (b) the control group
receiving and educational handbook and usual care. The primary outcome will be the cognitive
function. Secondary measures will be psychological distress, fatigue, sleep disturbance, quality of life
and occupational performance. The time-points for these measures will be placed at baseline, after
12 weeks and six months of post-randomization. Conclusion: This trial may support the inclusion of
multidimensional interventions through a telehealth approach in a worldwide growing population
suffering from breast cancer, emphasizing the prevention of cognitive impairment as one of the side
effects of cancer and its treatments.Spanish Government FPU17/00939
FPU18/03575Instituto de Salud Carlos III FI19/0023
Growing up in the deep-sea protected development in deep-sea invertebrates: A case study in the southwestern Atlantic Ocean
Marine invertebrates display a range of reproductive strategies, from external fertilization to several methods to protect the young. Both brooding or protected development of benthic species and direct development species (when juveniles born in a smaller version of its adult form) involves reducing the time that the larvae and/or juveniles spend in the plankton. The different forms of juvenile protection are often associated with the taxonomic group, although certain groups are much diversified in terms of their reproductive modes. However, the area where the species live also seems to play a key role. Several authors have indicated the unusual proportion of brooding species in the Southern Ocean, in particular in the southwestern Atlantic, including its adjacent deep-sea. The knowledge about the reproductive characteristics of most of the fauna in this area remains unknown. Proof of this are the great number of studies carried out in recent years, describing the reproductive features of several species (many also new), with some of them having many peculiarities about their biology.Fil: Teso, Silvia Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Martinez, Mariano Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Lauretta, Daniel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Pastorino, Roberto Santiago Guido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Urteaga, Diego Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Averbuj, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biología de Organismos Marinos; ArgentinaFil: Brogger, Martin Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biología de Organismos Marinos; ArgentinaFil: Arrighetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Rivadeneira, Pamela Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Flores, Jonathan Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Pertossi, Renata Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Sánchez, Noelia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Pacheco, Leonel Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Di Luca, Javier Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Sanchez Antelo, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Risaro, Jessica Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Ciocco, Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Penchaszadeh, Pablo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentin
Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial
The authors thank the Asociación Española Contra el Cáncer
(IDEAS19055CANT), the Spanish Ministry of Education Culture
and Sport (MECD) (FPU17/00939, FPU18/03575), the Carlos III
Health Institute (FI19/00230), and Carlos III Health Insitute and the
European Regional Development Fund (FEDER) (PI18/01840), for
funding this study and all participants of the study. IEC is supported
by the Spanish Ministry of Economy and Competitiveness. This study
was part of a Ph.D thesis conducted in the Clinical Medicine and
Public Health Doctoral Studies of the University of Granada, Spain.
Trial registration: ClinicalTrials. Gov identifier: NCT04583124.A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). This superiority randomized controlled trial aims to examine the feasibility and efficacy of an 8-week multimodal intervention (ATENTO) based on moderate-vigorous intensity and individualized TE (aerobic and strength exercises) and VAT (myofascial and breathing exercises), on neurotoxicity prevention in women with BC before starting adjuvant chemotherapy (ATENTO-B) versus throughout adjuvant chemotherapy (ATENTO-T). A sample of 56 women newly diagnosed with BC, as calculated with a power of 85%, will be randomly allocated into these two groups. This study could provide an impetus for the introduction of early multimodal intervention methods to prevent neurotoxicity and consequently avoid the QoL deterioration that BC patients presently suffer throughout their treatments.Fundacion Cientifica Asociacion Espanola Contra el Cancer
IDEAS19055CANTSpanish Ministry of Education Culture and Sport
FPU17/00939
FPU18/03575Instituto de Salud Carlos III
FI19/00230
PI18/01840Fondos Estructurales de la Union Europea (FEDER)
PI18/01840Spanish Ministry of Economy and Competitivenes
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