Sistemes d'imatge mèdica

Sistemes d'imatge mèdic

Sparse Givens resolution of large system of linear equations: applications to image reconstruction

In medicine, computed tomographic images are reconstructed from a large number of measurements of X-ray transmission through the patient (projection data). The mathematical model used to describe a computed tomography device is a large system of linear equations of the form AX=B. In this paper we propose the QR decomposition as a direct method to solve the linear system. QR decomposition can be a large computational procedure. However, once it has been calculated for a specific system, matrices Q and R are stored and used for any acquired projection on that system. Implementation of the QR decomposition in order to take more advantage of the sparsity of the system matrix is discussed.This work is partially supported by Generalitat Valenciana GVPRE/2008/303 and the Spanish M.E.C. grant MTM2009-08587.Rodríguez Álvarez, MJ.; Sánchez, F.; Soriano Asensi, A.; Iborra Carreres, A. (2010). Sparse Givens resolution of large system of linear equations: applications to image reconstruction. Mathematical and Computer Modelling. 52(7-8):1258-1264. https://doi.org/10.1016/j.mcm.2010.03.01612581264527-

In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC

[EN] In recent years high efforts have been devoted to enhance spatial and temporal resolutions of PET detectors. However, accurately combining these two main features is, in most of the cases, challenging. Typically, a compromise has to be made between the number of readout channels, scintillator type and size, and photosensors arrangement if aiming for a good system performance, while keeping a moderate cost. In this work, we have studied several detector configurations for PET based on a set of 8x8 Silicon Photomultiplier (SiPMs) of 3x3 mm(2) active area, and LYSO crystal arrays with different pixel sizes. An exhaustive evaluation in terms of spatial, energy and timing resolution was made for all detector configurations. In some cases, when using pixel sizes different than SiPM active area, a significant amount of scintillation light may spread among several SiPMs. Therefore, we made use of a calibration method considering the different SiPM timing contributions. Best Detector Time Resolution (DTR) of 156 ps FWHM was measured when using 3x3 mm(2) crystal pixels directly coupled to the 3x3 mm(2) SiPMs. However, when using 1.5 mm crystal pixels with the same photosensor array, although we could clearly resolve all crystal pixels, an average DTR of 250 ps FWHM was achieved. We also shed light in this work on the timing dependency of the crystal pixel and photosensor alignment.This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 695536) and by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R. The first author has also been supported by Generalitat Valenciana, Spain under grant agreement GRISOLIAP-2018-026.Lamprou, E.; Sánchez Martínez, F.; Benlloch Baviera, JM.; González Martínez, AJ. (2020). In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC. Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment. 977:1-8. https://doi.org/10.1016/j.nima.2020.164295S18977Jones, T., & Townsend, D. (2017). History and future technical innovation in positron emission tomography. Journal of Medical Imaging, 4(1), 011013. doi:10.1117/1.jmi.4.1.011013Surti, S. (2014). Update on Time-of-Flight PET Imaging. Journal of Nuclear Medicine, 56(1), 98-105. doi:10.2967/jnumed.114.145029Lecoq, P. (2017). Pushing the Limits in Time-of-Flight PET Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences, 1(6), 473-485. doi:10.1109/trpms.2017.2756674Surti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007Gundacker, S., Auffray, E., Pauwels, K., & Lecoq, P. (2016). Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Physics in Medicine and Biology, 61(7), 2802-2837. doi:10.1088/0031-9155/61/7/2802González-Montoro, A., Sánchez, F., Bruyndonckx, P., Cañizares, G., Benlloch, J. M., & González, A. J. (2019). Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 920, 58-67. doi:10.1016/j.nima.2018.12.056Moses, W. W. (2011). Fundamental limits of spatial resolution in PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 648, S236-S240. doi:10.1016/j.nima.2010.11.092Lamprou, E., Gonzalez, A. J., Sanchez, F., & Benlloch, J. M. (2020). Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs. Physica Medica, 70, 10-18. doi:10.1016/j.ejmp.2019.12.004Lamprou, E., Aguilar, A., González-Montoro, A., Monzó, J. M., Cañizares, G., Iranzo, S., … Benlloch, J. M. (2018). PET detector block with accurate 4D capabilities. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 132-136. doi:10.1016/j.nima.2017.11.002A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, et al. TOFPET2: A high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications, J. Instrum. 11 (03) C03042.Van Dam, H. T., Borghi, G., Seifert, S., & Schaart, D. R. (2013). Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation. Physics in Medicine and Biology, 58(10), 3243-3257. doi:10.1088/0031-9155/58/10/3243V. Nadig, D. Schug, B. Weissler, V. Schulz, Evaluation Of The PETsys TOFPET2 ASIC In Multi-Channel Coincidence Experiments, arXiv:1911.08156.Gundacker, S., Turtos, R. M., Auffray, E., Paganoni, M., & Lecoq, P. (2019). High-frequency SiPM readout advances measured coincidence time resolution limits in TOF-PET. Physics in Medicine & Biology, 64(5), 055012. doi:10.1088/1361-6560/aafd52Gundacker, S., Acerbi, F., Auffray, E., Ferri, A., Gola, A., Nemallapudi, M. V., … Lecoq, P. (2016). State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs. Journal of Instrumentation, 11(08), P08008-P08008. doi:10.1088/1748-0221/11/08/p0800

Exploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMs

[EN] Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 x 50 x 15 mm(3) coupled to SiPM arrays (8 x 8 elements with 6 x 6 mm(2) area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 x 3 x 5 mm(3) LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included.This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 695536). It has also been supported by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R.Lamprou, E.; González Martínez, AJ.; Sánchez Martínez, F.; Benlloch Baviera, JM. (2020). Exploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMs. Physica Medica. 70:10-18. https://doi.org/10.1016/j.ejmp.2019.12.004101870Surti, S. (2014). Update on Time-of-Flight PET Imaging. Journal of Nuclear Medicine, 56(1), 98-105. doi:10.2967/jnumed.114.145029Spanoudaki, V. C., & Levin, C. S. (2010). Photo-Detectors for Time of Flight Positron Emission Tomography (ToF-PET). Sensors, 10(11), 10484-10505. doi:10.3390/s101110484Szczesniak, T., Moszynski, M., Swiderski, L., Nassalski, A., Lavoute, P., & Kapusta, M. (2009). Fast Photomultipliers for TOF PET. IEEE Transactions on Nuclear Science, 56(1), 173-181. doi:10.1109/tns.2008.2008992Renker, D. (2007). New trends on photodetectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 571(1-2), 1-6. doi:10.1016/j.nima.2006.10.016Kim, C. L., Wang, G.-C., & Dolinsky, S. (2009). Multi-Pixel Photon Counters for TOF PET Detector and Its Challenges. IEEE Transactions on Nuclear Science, 56(5), 2580-2585. doi:10.1109/tns.2009.2028075Moses, W. W. (2002). Current trends in scintillator detectors and materials. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 487(1-2), 123-128. doi:10.1016/s0168-9002(02)00955-5Gundacker, S., Auffray, E., Pauwels, K., & Lecoq, P. (2016). Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Physics in Medicine and Biology, 61(7), 2802-2837. doi:10.1088/0031-9155/61/7/2802Gundacker, S., Acerbi, F., Auffray, E., Ferri, A., Gola, A., Nemallapudi, M. V., … Lecoq, P. (2016). State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs. Journal of Instrumentation, 11(08), P08008-P08008. doi:10.1088/1748-0221/11/08/p08008Surti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007Gundacker, S., Knapitsch, A., Auffray, E., Jarron, P., Meyer, T., & Lecoq, P. (2014). Time resolution deterioration with increasing crystal length in a TOF-PET system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 737, 92-100. doi:10.1016/j.nima.2013.11.025Marcinkowski, R., España, S., Van Holen, R., & Vandenberghe, S. (2014). Optimized light sharing for high-resolution TOF PET detector based on digital silicon photomultipliers. Physics in Medicine and Biology, 59(23), 7125-7139. doi:10.1088/0031-9155/59/23/7125González-Montoro, A., Sánchez, F., Martí, R., Hernández, L., Aguilar, A., Barberá, J., … González, A. J. (2018). Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 372-377. doi:10.1016/j.nima.2017.10.098Xi, D., Xie, Q., Zhu, J., Lin, L., Niu, M., Xiao, P., … Kao, C.-M. (2012). Optimization of the SiPM Pixel Size for a Monolithic PET Detector. Physics Procedia, 37, 1497-1503. doi:10.1016/j.phpro.2012.04.101Gonzalez-Montoro A, Aguilar A, Canizares G, Conde P, Hernandez L, Vidal LF, et al. Performance Study of a Large Monolithic LYSO PET Detector With Accurate Photon DOI Using Retroreflector Layers. IEEE Trans Rad Plasma Med Sci. PP. 1-1. DOI: 10.1109/TRPMS.2017.2692819.Krishnamoorthy, S., Blankemeyer, E., Mollet, P., Surti, S., Van Holen, R., & Karp, J. S. (2018). Performance evaluation of the MOLECUBES β-CUBE—a high spatial resolution and high sensitivity small animal PET scanner utilizing monolithic LYSO scintillation detectors. Physics in Medicine & Biology, 63(15), 155013. doi:10.1088/1361-6560/aacec3González-Montoro, A., Sánchez, F., Bruyndonckx, P., Cañizares, G., Benlloch, J. M., & González, A. J. (2019). Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 920, 58-67. doi:10.1016/j.nima.2018.12.056Van Dam, H. T., Borghi, G., Seifert, S., & Schaart, D. R. (2013). Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation. Physics in Medicine and Biology, 58(10), 3243-3257. doi:10.1088/0031-9155/58/10/3243Di Francesco A, Bugalho R, Oliveira L, Pacher L, Rivetti A, Rolo M, et al. TOFPET2: A high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications. Journal of Instrumentation, vol. 11, no. 03, p. C03042.TOFPET2 ASIC Evaluation kit - Hardware User Guide (v1.2), v1.2, PETsys Electronics SA., 2018.Lamprou, E., Aguilar, A., González-Montoro, A., Monzó, J. M., Cañizares, G., Iranzo, S., … Benlloch, J. M. (2018). PET detector block with accurate 4D capabilities. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 132-136. doi:10.1016/j.nima.2017.11.002Acerbi, F., & Gundacker, S. (2019). Understanding and simulating SiPMs. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 926, 16-35. doi:10.1016/j.nima.2018.11.118Schug D, Nadig V, Weissler B, Gebhardt P, Schulz V. Initial Measurements with the PETsys TOFPET2 ASIC Evaluation Kit and a Characterization of the ASIC TDC IEEE Trans Rad Plasma Med Sci. PP. 1-1. DOI: 10.1109/TRPMS.2018.2884564.Seifert, S., van Dam, H. T., Vinke, R., Dendooven, P., Lohner, H., Beekman, F. J., & Schaart, D. R. (2012). A Comprehensive Model to Predict the Timing Resolution of SiPM-Based Scintillation Detectors: Theory and Experimental Validation. IEEE Transactions on Nuclear Science, 59(1), 190-204. doi:10.1109/tns.2011.2179314Vinke R, Olcott PD, Cates JW, Levin CS. The lower timing resolution bound for scintillators with non-negligible optical photon transport time in time-of-flight PET. Phys. Med. Phys. Med. Biol. 59 6215. Phys Med Biol. 2014; 59(20): 6215–29.Gonzalez AJ, Sanchez F, Benlloch JM. 2018 Organ-Dedicated Molecular Imaging Systems. IEEE Trans Ratiat Plasma Med Sci. 2017; 2(5): 388–403

Helical ensembles outperform ideal helices in molecular replacement

The conventional approach in molecular replacement (MR) is the use of a related structure as a search model. However, this is not always possible as the availability of such structures can be scarce for poorly characterised families of proteins. In these cases, alternative approaches can be explored, such as the use of small ideal fragments that share high albeit local structural similarity with the unknown protein. Earlier versions of AMPLE enabled the trialling of a library of ideal helices, which worked well for largely helical proteins at suitable resolution. Here we explore the performance of libraries of helical ensembles created by clustering helical segments. The impacts of different B-factor treatments and different degrees of structural heterogeneity are explored. We observed a 30% increase in the number of solutions obtained by AMPLE when using this new set of ensembles compared to performance with ideal helices. The boost of performance was notable across three different folds: transmembrane, globular and coiled-coil structures. Furthermore, the increased effectiveness of these ensembles was coupled to a reduction of the time required by AMPLE to reach a solution. AMPLE users can now take full advantage of this new library of search models by activating the “helical ensembles” mode

Calibration of Gamma Ray Impacts in Monolithic-Based Detectors Using Voronoi Diagrams

[EN] Molecular imaging systems, such as positron emission tomography (PET), use detectors providing energy and a 3-D interaction position of a gamma ray within a scintillation block. Monolithic crystals are becoming an alternative to crystal arrays in PET. However, calibration processes are required to correct for nonuniformities, mainly produced by the truncation of the scintillation light distribution at the edges. We propose a calibration method based on the Voronoi diagrams. We have used $50 \times 50 \times 15$ mm(3) LYSO blocks coupled to a $12\times 12$ SiPMs array. We have first studied two different interpolation algorithms: 1) weighted average method (WAM) and 2) natural neighbor (NN). We have compared them with an existing calibration based on 1-D monomials. Here, the crystal was laterally black painted and a retroreflector (RR) layer added to the entrance face. The NN exhibited the best results in terms of XY impact position, depth of Interaction, and energy, allowing us to calibrate the whole scintillation volume. Later, the NN interpolation has been tested against different crystal surface treatments, allowing always to correct edge effects. Best energy resolutions were observed when using the reflective layers (12%-14%). However, better linearity was observed with the treatments using black paint. In particular, we obtained the best overall performance when lateral black paint is combined with the RR.This work was supported in part by the European Research Council through the European Union's Horizon 2020 Research and Innovation Program under Grant 695536, and in part by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R.Freire, M.; Gonzalez-Montoro, A.; Sánchez Martínez, F.; Benlloch Baviera, JM.; González Martínez, AJ. (2020). Calibration of Gamma Ray Impacts in Monolithic-Based Detectors Using Voronoi Diagrams. IEEE Transactions on Radiation and Plasma Medical Sciences. 4(3):350-360. https://doi.org/10.1109/TRPMS.2019.2947716S3503604

Progress report on the MEDAMI 2019 and CTR research at the DMIL in i3M

[EN] This contribution reports on the recently held MEDAMI 2019 workshop in Valencia (15-17th May 2019). This workshop is about advanced molecular imaging and the main topic of this last edition was Imaging in Immunotherapy. Around 70 attenders met together during three days. This meeting made it possible to join medical doctors and instrumentalists. In MEDAMI 2019 it was exposed the new immunotherapies from a clinical and research point of view. It was shown the already observed improvements when using these therapies. At the same time, we heard about the difficulties and limitations of current molecular imaging in this particular field. It was clear that improvements in system sensitivity and resolution are demanded. Timing information can be utilized in different ways to improve the image quality in PET systems. Precise Coincidence Time Resolution (CTR) improves the signal-to-noise ratio and, therefore, the image contrast, allowing for instance to distinguish low uptake tumors, multicentric lesions, or tumor heterogeneity, to name but a few. Both high time resolution and angular coverage in a PET system can improve the effective sensitivity. An example of a system benchmarking the timing resolution is the Siemens Biograph Vision with 214 ps FWHM, enhancing the detectability. The Explorer total-body PET from UC Davis improves the system sensitivity by having a 2 meters long PET scanner. Deep investigations, from different research groups, are being carried out to further push the limits of timing resolution. This work also describes some of the projects on high timing performance that are being carried out at the Detector for Molecular Imaging Lab (DMIL) at the Institute for Instrumentation in Molecular Imaging (i3M) in Valencia. The DMIL group has extensively worked on detectors and implementation of PET systems enabling the use of accurate timing information. In this progress report we describe the results obtained at the DMIL regarding timing determination in gamma-ray detectors both based on monolithic and pixelated crystals. Although with 15 min thick LYSO blocks it was tough to obtain values of CTR below 500 ps when using analog SiPMs and ASIC-based readout, this was improved down to 250 ps if small 3 mm size and 6 mm height pixels under the one-to-one coupling approach were enabled. This type of approach, the one-to-one coupling, seems to benefit from the light collection in a single photosensor element and, therefore, to improve the timing properties. Monolithic blocks offer, on the contrary, advantages such as photon depth of interaction. In order to separate Compton and photoelectric events we have thought of a detector block design with a high aspect ratio, using LYSO crystals of 51 mm size vs. 3 mm thickness, read-out by the four lateral sides. We have demonstrated the possibility to reach below 2 mm FWHM spatial resolution with an energy resolution of 12%.The DMIL work presented in this paper has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 695536). It has also been supported by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R. The author would like to thank all current and former members of the DMIL at i3M for their continuous contributions to this work.González Martínez, AJ.; Barrio, J.; Lamprou, E.; Ilisie, V.; Sánchez Martínez, F.; Benlloch Baviera, JM. (2020). Progress report on the MEDAMI 2019 and CTR research at the DMIL in i3M. Il Nuovo cimento C. 43(1):1-10. https://doi.org/10.1393/ncc/i2020-20005-8S11043

High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study

[EN] Gamma cameras are of great interest due to their high potential in the field of Nuclear Medicine Imaging. They allow for an early diagnosis of reduced size tumors, and also for a wide variety of preclinical studies with the aim of designing more effective treatments against cancer. In this work we propose a significantly improved multi-pinhole collimator gamma camera and perform a first Monte Carlo analysis of its characteristics. Maintaining the configuration of a multi-pinhole collimator with a high degree of overlapping (thus with a high sensitivity), we add a new element, an active septa, that besides acting as a collimator, is able to measure the impact coordinates of the incident photon. This way one is able to unambiguously identify through which pinhole any gamma ray passes before being detected. The result is a high sensitivity and resolution multi-pinhole gamma camera with an arbitrarily large field of view. As a consequence, the final reconstructed image does not suffer from the undesired artifacts or truncation associated to the multiplexing phenomenon. In this study we focus on the development of a system able to visualize in 3D tumors, nodes and metastasis in real time in the operating room with very low dose. We also briefly analyse and propose a novel design for a Single Photon Emission Computed Tomography system.This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant Agreement No. 695536). This work was supported in part by the Spanish Government Grants Generalitat Valenciana, APOSTD/2019/086 and TEC2016-79884-C2 and RTC-2016-5186-1.Ilisie, V.; Moliner, L.; Oliver-Gil, S.; Sánchez Martínez, F.; González Martínez, AJ.; Seimetz, M.; Rodríguez Álvarez, MJ.... (2019). High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study. Scientific Reports. 9:1-9. https://doi.org/10.1038/s41598-019-54934-0S199Mok, G. S. P., Tsui, B. M. W. & Beekman, F. J. The effects of object activity distribution on multiplexing multi-pinhole SPECT. Phys. Med. Biol. 56, 2635–2650 (2011).Johnson, C., Shokouhi, S. & Peterson, T. E. Reducing Multiplexing artifacts in Multi-Pinhole SPECT with a Stacked Silicon-Germanium System: a Simulation Study. IEEE Trans Med Imaging. 33(12), 2342–2351 (2014).Mok, G. S. P., Wang, Y. & Tsui, B. M. W. Quantification of the Multiplexing Effects in Multi-Pinhole Small Animal SPECT: A Simulation Study. IEEE Trans Nucl Sci. 56(5), 2636–2643 (2009).Vunckx, K., Suetens, P. & Nuyts, J. Effect of Overlapping Projections on Reconstruction Image Quality in Multipinhole SPECT. IEEE Transactions on Medical Imaging. 27(7) (2008).Ivashchenko, O. et al. Quarter-Millimeter-Resolution Molecular Mouse Imaging with U-SPECT+. Mol Imaging. 2014. 13 (2014).Gal, O. et al. Development of a portable gamma camera with coded apertura. Nuclear Instruments and Methods in Phys. Res. A. 563, 233–237 (2006).Accorsi, R., Gasparini, F. & Lanza, R. C. A Coded Aperture for High-Resolution Nuclear Medicine Planar Imaging With a Conventional Anger Camera: Experimental Results. IEEE Transactions on Nuclear Science. 48, 2411–2417 (2001).Fuji, H. et al. Optimization of Coded Aperture Radioscintigraphy for Sentinel Lymph Node Mapping. Mol. Imaging Biol. 14, 173–182 (2012).Accorsi, R., Gasparini, F. & Lanza, R. C. Optimal coded aperture patterns for improved SNR in nuclear medicine imaging. Nucl. Instrum. Methods Phys. Res. A. 474, 273–284 (2001).Lee, T. & Lee, W. Portable Active Collimation Imager Using URA Patterned Scintillator. IEEE Transactions on Nuclear Science. 61, 654–662 (2014).Lee, T. & Lee, W. A cubic gamma camera with an active collimator. Applied Radiation and Isotopes. 90, 102–108 (2014).Accorsi, R. & Lanza, R. C. Near-field artifact reduction in coded aperture imaging. Appl. Opt. 40, 4697–4705 (2001).Ilisie, V., Sánchez, F., González, A. J. & Benlloch, J. M. Dispositivo Para la Detección de Rayos Gamma con Tabiques Activos (Device for Gamma Ray Detection with Active Septa), Patent application Ref. P201831058/PT-018004.González, A. J. et al. Detector block based on arrays of 144 SiPMs and monolithic scintillators: A performance study. Nuclear Instruments and Methods in Physics Research A. 787, 42–45 (2015).Pani, R. et al. Preliminary evaluation of a monolithic detector module for integrated PET/MRI scanner with high spatial resolution. JINST. 10, C06006 (2015).Pani, R. et al. Continuous DOI determination by Gaussian modelling of linear and non-linear scintillation light distributions. Proc. IEEE NSS-MIC. 3386–3389 (2011).Shepp, L. A. & Vardi, Y. Maximum likelihood reconstruction for emission tomography. IEEE Transactions on Medical Imaging. 2, 113 (1982).Hudson, H. M. & Larkin, R. S. Accelerated Image Reconstruction Using Ordered Subsets of projection Data. IEEE Transactions on Medical Imaging. 13, 601 (1994).Reader, A. J. et al. Accelerated list-mode EM algorithm. IEEE Transactions on Nuclear Science. 49, 42 (2002).Rahmim, A., Ruth, T. & Sossi, V. Study of a convergent subsetized list-mode EM reconstruction algorithm. FILTR SEP. 6. 3978–3982. 6, 10.1109 (2004).Siddon, R. L. Fast calculation of the exact radiological path for a three-dimensional CT array. Medical Physics. 12, 252 (1985).Sundermann, E., Jacobs, F., Christiaens, M., De Sutter, B. & Lemahieu, I. A Fast Algorithm to Calculate the Exact Radiological Path Through a Pixel Or Voxel Space. Journal of Computing and Information Technology. 6 (1998).Reader, A. J. et al. One-pass list-mode EM algorithm for high-resolution 3-D PET image reconstruction into large arrays. IEEE Transactions on Nuclear Science. 49(3), 693–699 (2002).Agostinelli, S. et al. Geant4 - a simulation toolkit. Nuclear Instruments and Methods in Physics Research A. 506, 250–303 (2003).Jan, S. et al. GATE - Geant4 Application for Tomographic Emission: a simulation toolkit for PET and SPECT. Phys. Med. Biol. 49(19), 4543–4561 (2004)

Sistema compacto, híbrido e integrado GAMMA/RF para la formación de imágenes simultáneas PETSPECT/MR

Sistema compacto, híbrido e integrado GAMMA/RF para la formación de imágenes simultáneas PET-SPECT/MR. El sistema compacto, híbrido e integrado GAMMA-RF para la formación de imágenes simultáneas PET-SPECT/MR de la invención comprende un dispositivo GAMMA-RF que integra una bobina RF, del tipo empleado en sistemas MR convencionales, con unos módulos detectores de radiación GAMMA del tipo utilizado en sistemas PET o SPECT, de modo que se obtienen imágenes combinadas de las técnicas PET o SPECT y MR.Peer reviewedConsejo Superior de Investigaciones Científicas (España), Universidad de Valencia, Universidad Politécnica de Valencia, General Equipment for Medical Imaging SA, Exploraciones Radiológicas Especiales SA (ERESA)A1 Solicitud de patente con informe sobre el estado de la técnic

Exploiting symmetries for weight matrix design in CT imaging

In this paper we propose several methods of constructing the system matrix (SM) of a Computed Tomography (CT) scanner with two objectives: (1) to construct SMs in the shortest possible time and store them in an ordinary PC without losing quality, (2) to analyze the possible applications of the proposed method to 3D, taking into account SMs' sizes, computing time and reconstructed image quality. In order to build the SM, we propose two new field of view (FOV) pixellation schemes, based on a polar coordinate system (polar grid) by taking advantage of the polar rotation symmetries of CT devices. Comparisons between the SMs proposed are performed using two phantom and a real CT-simulator images. Global error, contrast, noise and homogeneity of the reconstructed images are discussed. © 2010 Elsevier Ltd.This work is partially supported by Generalitat Valenciana GVPRE/2008/303 and the Spanish M.E.C. Grant MTM2009-08587.Rodríguez-Álvarez, M.; Sánchez Martínez, F.; Soriano Asensi, A.; Iborra Carreres, A.; Mora Mora, C. (2011). Exploiting symmetries for weight matrix design in CT imaging. Mathematical and Computer Modelling. 54(7-8):1655-1664. https://doi.org/10.1016/j.mcm.2010.12.004S16551664547-