Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.Comment: 6 pages, 3 figure

Electron-Conformational Transformations in Nanoscopic RyR Channels Governing Both the Heart's Contraction and Beating

We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca2+ sarcoplasmic reticulum overload. © 2011 Pleiades Publishing, Ltd.This work was supported by the Ural Branch, Russian Academy of Sciences, project no. 09 M 14 2001

MODELING OF THE EFFECT OF INHIBITORS OF ION CHANNELS ON THE FUNCTIONING OF CARDIAC PACEMAKERS

Via the integrated model, that includes electron-conformational model of stochastic dynamics of ryanodine RyR channels (ECM) and Ca2+-releasing model, effect of various inhibitors of ion channels (ryanodine, lidocaine, nifedipine) on the frequency of action potential generation in sinoatrial node was investigated, and conditions of AP generation failure were observed

Strong Doping of the n-Optical Confinement Layer for Increasing Output Power of High- Power Pulsed Laser Diodes in the Eye Safe Wavelength Range

Abstract—An analytical model for internal optical losses at high power in a 1.5 μm laser diode with strong n-doping in the n-side of the optical confinement layer is created. The model includes intervalence band absorption by holes supplied by both current flow and two-photon absorption, as well as the direct two-photon absorption effect. The resulting losses are compared with those in an identical structure with a weakly doped waveguide, and shown to be substantially lower, resulting in a significant improvement in the output power and efficiency in the structure with a strongly doped waveguid

MODIFICATION OF RYANODINE-SENSITIVE CALCIUM RELEASE CHANNELS GATING AND CALCIUM DYNAMICS IN CARDIOMYOCYTES BY TEMPERATURE IN ELECTRON-CONFORMATIONAL THEORY

We took into account a temperature in an Electron-Conformational Model of SR-based Ca2+ Clock (ECM Clock). The results of modelling of ECM Clock show that higher temperature gives lower amplitude of cytosolic Ca2+ and higher frequency of oscillations and lower temperature destroys ECM Clock.Исследования поддержаны Программой повышения конкурентоспособности ведущих университетов РФ (постановление Правительства РФ № 211 от 16 марта 2013 г.)

Dynamic modelling of electrooptically modulated vertical compound cavity surface emitting semiconductor lasers

A generalized rate equation model is used to simulate the interrelated amplitude and frequency modulation properties of Electrooptically Modulated Vertical Compound Cavity Surface Emitting Semiconductor Lasers in both large and small signal modulation regimes. It is shown that the photon lifetime in the modulator subcavity provides the ultimate limit for the 3 dB modulation cutoff frequency. It is shown that there is an optimum design (number of periods) of both the intermediate and top multistack reflectors to maximise the large-signal modulation quality

Mapping polyclonal antibody responses to bacterial infection using next generation phage display

Mapping polyclonal antibody responses to infectious diseases to identify individual epitopes has the potential to underpin the development of novel serological assays and vaccines. Here, phage-peptide library panning coupled with screening using next generation sequencing was used to map antibody responses to bacterial infections. In the first instance, pigs experimentally infected with Salmonella enterica serovar Typhimurium was investigated. IgG samples from twelve infected pigs were probed in parallel and phage binding compared to that with equivalent IgG from pre-infected animals. Seventy- seven peptide mimotopes were enriched specifically against sera from multiple infected animals. Twenty-seven of these peptides were tested in ELISA and twenty-two were highly discriminatory for sera taken from pigs post-infection (P < 0.05) indicating that these peptides are mimicking epitopes from the bacteria. In order to further test this methodology, it was applied to differentiate antibody responses in poultry to infections with distinct serovars of Salmonella enterica. Twenty-seven peptides were identified as being enriched specifically against IgY from multiple animals infected with S. Enteritidis compared to those infected with S. Hadar. Nine of fifteen peptides tested in ELISA were highly discriminatory for IgY following S. Enteritidis infection (p < 0.05) compared to infections with S. Hadar or S. Typhimurium