53 research outputs found

    Corn Cockle ( Agrostemma githago

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    Synthesis of BODIPY derivatives for photodynamic therapy

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    Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Author: Milan Rydrych Supervisor: Prof. PharmDr. Petr Zimčík, PhD. Name of the thesis: Synthesis of BODIPY dyes for photodynamic therapy Borron-dipyromethene dyes (BODIPYs) have been used since the 1990s for their photostability, high absorption coefficients and fluorescence quantum yields. Recently, a modification of the structure using the heavy atom effect was discovered, where high quantum yields of singlet oxygen were also achieved. This fact helped creating a family of compounds with the potential for use in photodynamic therapy (PDT). Previously described BODIPY preparations for PDT are limited by poor solubility in polar environments. This study provides an overview of current synthetic options and basic structure-effect relationships. In the experimental part of the work, three styryl disubstituted substances were prepared with λmax (absorption maximum) at wavelengths in near infrared region with good quantum yields of singlet oxygen and very good photostability. In addition to the target compounds, three 3,5- dialkoxy substituted benzaldehyde derivatives were prepared and characterized as precursors for the final compounds. Finally, the already published synthetic..

    Analýza způsobu financování ve zdravotnictví

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    Import 19/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Ekonomická fakulta. Katedra (154) financ

    Ethnocultural Identity of Roma Pupulation in Neratovice.

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    This masters's thesis is concerned with the ethnocultural identity of Roma population in Neratovice. Considering the data obtained from the Czech Population and Housing Census carried out in 2001, this paper aims to examine both the reasons and motives of the Roma population majority for declaring themselves the Czechs or the Slovaks rather than Romanies, and to what extent this Roma non-declaration of ethnicity corresponds with the ethnocultural identity awareness of particular individuals

    Synthesis of BODIPY derivatives for photodynamic therapy

    No full text
    Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Author: Milan Rydrych Supervisor: Prof. PharmDr. Petr Zimčík, PhD. Name of the thesis: Synthesis of BODIPY dyes for photodynamic therapy Borron-dipyromethene dyes (BODIPYs) have been used since the 1990s for their photostability, high absorption coefficients and fluorescence quantum yields. Recently, a modification of the structure using the heavy atom effect was discovered, where high quantum yields of singlet oxygen were also achieved. This fact helped creating a family of compounds with the potential for use in photodynamic therapy (PDT). Previously described BODIPY preparations for PDT are limited by poor solubility in polar environments. This study provides an overview of current synthetic options and basic structure-effect relationships. In the experimental part of the work, three styryl disubstituted substances were prepared with λmax (absorption maximum) at wavelengths in near infrared region with good quantum yields of singlet oxygen and very good photostability. In addition to the target compounds, three 3,5- dialkoxy substituted benzaldehyde derivatives were prepared and characterized as precursors for the final compounds. Finally, the already published synthetic..

    Downy Brome ( Bromus tectorum

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