14 research outputs found
The Creative Urge - An Attempt to find Methods for the Creative Joy in the Artistic Work
I mitt masterarbete stÀller jag mig frÄgan om jag kan skapa en metod för att gynna den kreativa lusten. Jag som scenkonstnÀr förutsÀtts vara kreativ. Lust Àr en av mina starkaste drivkrafter och beskrivs inom kreativitetsforskningen som en aspekt av kreativitet. Genom att undersöka fler aspekter av kreativitet och koppla dem till min konstnÀrliga praktik, har jag prövat att skapa ett nÀtverk av aspekterna och dÀrigenom en metod. NÀtverket har jag sedan aktiverat och applicerat pÄ mig sjÀlv som skÄdespelare i ett sceniskt arbete och pÄ mitt skrivande, hela tiden med fokus pÄ den kreativa lusten. PÄ följande sidor kan du lÀsa vad jag gjort och hur. Min förhoppning Àr att du som lÀsare fÄr inspiration till att pröva och anvÀnda det jag undersökt och se vad som hÀnder. Kanske fÄr du lust? VÀlkommen
Chemical-Looping Combustion and Chemical-Looping Reforming in a Circulating Fluidized-Bed Reactor Using Ni-Based Oxygen Carriers
Novel Octabrominated Phenolic Diphenyl Ether Identified in Blue Mussels from the Swedish West Coast
Hydroxylated
(OHâ) and methoxylated (MeOâ) polybrominated
diphenyl ethers (PBDEs) are compounds present in the marine environment
and OHâPBDEs are of toxicological concern and are therefore
of interest to monitor in the environment. A phenolic octaBDE was
tentatively identified in the phenolic fraction of previously analyzed
mussel samples after methylation of the halogenated phenolic compounds
(HPCs). The aim of the present study was to confirm the identity of
this compound in blue mussels and investigate whether the analyte
is diOHâ and/or OHâMeOâoctaBDE. Two reference
standards, 6,6âČ-dimethoxy-2,2âČ,3,3âČ,4,4âČ,5,5âČ-octabromodiphenyl
ether (6,6âČ-diMeOâBDE194) and 6-ethoxy-6âČ-methoxy-2,2âČ,3,3âČ,4,4âČ,5,5âČ-octabromodiphenyl
ether (6-EtO-6âČ-MeOâBDE194) were prepared via <i>O</i>-arylation of 2,3,4,5-tetrabromo-6-methoxyphenol and 2,3,4,5-tetrabromo-6-ethoxyphenol,
respectively, with a novel unsymmetrical diaryliodonium salt, 2,3,4,5-tetrabromo-6-methoxydiphenyliodonium
triflate. The GC retention time and GC/MS spectrum of the synthesized
6,6âČ-diMeOâBDE194 correspond well with the analyte in
the methylated phenolic fraction of a mussel extract from a previous
study. Structural analysis performed in this study indicate that the
synthesized 6,6âČ-diMeOâBDE194 and 6-EtO-6âČ-MeOâBDE194
correspond well with 6-hydroxy-6âČ-methoxy-2,2âČ,3,3âČ,4,4âČ,5,5âČ-octabromodiphenyl
ether (6-OHâ6âČ-MeOâBDE194) after methylation
and ethylation, respectively, of the HPCs in the mussel extracts.
The compound 6-OHâ6âČ-MeOâBDE194 was identified
and quantified in new mussels, sampled in 2012 from two locations
on the Swedish west coast, with geometric mean concentrations of 3700
and 410 ng/g fat, respectively
Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2âSelective Inhibitors
A series of substituted chromone/chroman-4-one derivatives
has
been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme
involved in aging-related diseases, e.g., neurodegenerative disorders.
The analogues were efficiently synthesized in a one-step procedure
including a base-mediated aldol condensation using microwave irradiation.
The most potent compounds, with inhibitory concentrations in the low
micromolar range, were substituted in the 2-, 6-, and 8-positions.
Larger, electron-withdrawing substituents in the 6- and 8-positions
were favorable. The most potent inhibitor of SIRT2 was 6,8-dibromo-2-pentylchroman-4-one
with an IC<sub>50</sub> of 1.5 ÎŒM. The synthesized compounds
show high selectivity toward SIRT2 over SIRT1 and SIRT3 and represent
an important starting point for the development of novel SIRT2 inhibitors
Role of Follistatin in Promoting Adipogenesis in Women
Context: Follistatin is a glycoprotein that binds and neutralizes biological activities of TGFÎČ superfamily members including activin and myostatin. We previously identified by expression profiling that follistatin levels in white adipose tissue (WAT) were regulated by obesity