Print Mass Media as a Government Tool in Strategic Communications: A Study Based on Content Analysis of Publications in Russia

The article examines the socio-demographic characteristics of Russian print media readership along with a content analysis of press publications with a view of understanding the role of media in shaping public opinion from the perspective of theory and practice of strategic communication. A timely example of a resonant social process is considered in retrospect, showing the insufficient effectiveness of strategic government communications in Russia and the problems of information interaction in society. Several hypotheses were defined on the ways to improve the effectiveness of government strategic communications. Based on the research results, the authors suggest ways to optimize this practice, aimed at achieving more holistic and desired results in terms of stability and sustainability of socio-economic processes. The study determined that the use of complex tools and one-way communication methods through print media is not enough for effective “implementation” of the state’s position on the solution of the problem situation

Comparative evaluation of functional constipation prevention methods in pregnant women

Aim. To perform a comparative evaluation of different methods for preventing functional constipation in pregnant women. Materials and methods. The study included 150 pregnant women aged 18 to 42 years, 22 to 36 weeks of gestation, with functional constipation. Group 1 included 50 patients who received dietary fiber OptiFibre in addition to diet therapy; group 2 included 50 patients who received diet therapy in combination with lactulose; group 3, the control group, included 50 pregnant women who received corrective diet therapy only. The outcomes were evaluated on day 14 of observation. Results. A diet only was not sufficiently effective in normalizing stools in pregnant women with a gestational age of 2236 weeks. By day 14, stool frequency was restored in groups 1 and 2 patients. However, during lactulose use, gastrointestinal discomfort persisted more frequently; not all patients reported normal stools at the medium recommended dose, which required an increase of the dose. However, there were episodes of loose stool, which required discontinuation of the medicine. The best results were achieved with the combination of diet and partially hydrolyzed OptiFibre dietary fibers, both in terms of restoration of stool regularity, relief of associated gastrointestinal symptoms, and tolerance of the dietary fibers. Conclusion. Soluble dietary fiber OptiFibre, combined with diet therapy, restores regular stools and resolves constipation in pregnant women. It is well tolerated and safe to use in obstetric practice. The findings suggest using OptiFibre for constipation in pregnant women

Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-bipyridine and (5'-phenyl-[2,2'-bipyridin]-6-yl)methyl formate were isolated as by-products in some cases. Finally, an improved procedure for the DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines by using Finkelstein reaction was developed

New 2,5-bis(2-ethylhexyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione-2,2’-bipyridine-based co-polymer, synthesis, photophysical properties and response to metal cations

A new co-polymer based on fragments of 2-(2-pyridyl)monoazatriphenylene and 2,5-bis (2-ethylhexyl)-3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione was prepared by using the Sonogashira reaction. The photophysical properties of the polymer were studied. The presence of a strong bathochromic shift of the absorption and emission maxima in comparison with the previously described monomer units is shown. The polymer exhibits an intense “turn-off” response toward Cu2+ cations

The synthesis of aminophenyl-substituted 2,2'-bipyridine ligands by "1,2,4-triazine" methodology

A convenient synthetic approach to the 2,2'-bipyridines, including those with a condensed cyclopentene fragment, having an aminophenyl substituent at the C5 or C6 positions is reported. The products were obtained via their 1,2,4-triazine analogs with a nitro group, by the subsequent transformation of their 1,2,4-triazine ring into a pyridine one and the reduction of the nitro group to the amino group. © 2021 Author(s).Russian Science Foundation, RSF, (20-13-00142)Council on grants of the President of the Russian Federation, (NSh-2700.2020.3)This work was supported by the Russian Science Foundation (Grant # 20-13-00142) and by the Grants Council of the President of Russian Federation (Grant # NSh-2700.2020.3)

New trends in the economic systems management in the context of modern global challenges

New trends in the economic systems management in the context of modern global challenges: collective monograph / scientific edited by M. Bezpartochnyi, in 2 Vol. // VUZF University of Finance, Business and Entrepreneurship. – Sofia: VUZF Publishing House “St. Grigorii Bogoslov”, 2020. – Vol. 1. – 309 p

Излечение саркоидоза по данным диспансерного наблюдения 1992— 1999 гг.

Sarcoidosis coruse was analyzed in 103 patients with long-term loss of sarcoidosis activity and 25 recovered ones. Favourable factors included well-timed diagnosing of the disease, initial moderate inhibition of immune system, an absence of pronounced bronchial obstruction. An acute course with fever, accelerated erythrocytes settling rate and lymphocytosis of broncho-alveolar lavage fluid are not considered to be signs of poor outcome.Анализировалось течение саркоидоза у 103 больных с длительной потерей активности процесса и у 25 человек с излечением. К числу благоприятных факторов течения отнесены: своевременное выявление заболевания, умеренно выраженное исходное снижение иммунитета, отсутствие выраженных обструктивных изменений бронхов. Острое течение с лихорадкой, высокой СОЭ, УЭ и лимфоцитозом БАС не являются признаками плохого прогноза

Computational Study of the Human Dystrophin Repeats: Interaction Properties and Molecular Dynamics

Dystrophin is a large protein involved in the rare genetic disease Duchenne muscular dystrophy (DMD). It functions as a mechanical linker between the cytoskeleton and the sarcolemma, and is able to resist shear stresses during muscle activity. In all, 75% of the dystrophin molecule consists of a large central rod domain made up of 24 repeat units that share high structural homology with spectrin-like repeats. However, in the absence of any high-resolution structure of these repeats, the molecular basis of dystrophin central domain's functions has not yet been deciphered. In this context, we have performed a computational study of the whole dystrophin central rod domain based on the rational homology modeling of successive and overlapping tandem repeats and the analysis of their surface properties. Each tandem repeat has very specific surface properties that make it unique. However, the repeats share enough electrostatic-surface similarities to be grouped into four separate clusters. Molecular dynamics simulations of four representative tandem repeats reveal specific flexibility or bending properties depending on the repeat sequence. We thus suggest that the dystrophin central rod domain is constituted of seven biologically relevant sub-domains. Our results provide evidence for the role of the dystrophin central rod domain as a scaffold platform with a wide range of surface features and biophysical properties allowing it to interact with its various known partners such as proteins and membrane lipids. This new integrative view is strongly supported by the previous experimental works that investigated the isolated domains and the observed heterogeneity of the severity of dystrophin related pathologies, especially Becker muscular dystrophy