An Intensity Mapping Detection of Aggregate CO Line Emission at 3 mm

We present a detection of molecular gas emission at $z\sim1-5$ using the technique of line intensity mapping. We make use of a pair of 3 mm interferometric data sets, the first from the ALMA Spectroscopic Survey in the Hubble Ultra Deep Field (ASPECS), and the second from a series of Atacama Compact Array (ACA) observations conducted between 2016 and 2018, targeting the COSMOS field. At 100 GHz, we measure non-zero power at 97.8% and 99.9% confidence in the ACA and ALMA data sets, respectively. In the joint result, we reject the zero-power hypothesis at 99.99% confidence, finding $\tilde{I}^{2}_{s}(\nu)=770\pm210\ \mu\textrm{K}^2\ \textrm{Hz}\ \textrm{sr}$. After accounting for sample variance effects, the estimated spectral shot power is $\tilde{I}^{2}_{s}(\nu)=1010_{-390}^{+550}\ \mu\textrm{K}^2\ \textrm{Hz}\ \textrm{sr}$. We derive a model for the various line species our measurement is expected to be sensitive to, and estimate the shot power to be$120_{-40}^{+80}\ \mu\textrm{K}^2\ h^{-3}\,\textrm{Mpc}^{3}$,$200^{+120}_{-70}\ \mu\textrm{K}^2\ h^{-3}\,\textrm{Mpc}^{3}$, and$90^{+70}_{-40}\ \mu\textrm{K}^2\ h^{-3}\,\textrm{Mpc}^{3}$for CO(2-1) at$z=1.3$, CO(3-2) at$z=2.5$, and CO(4-3) at$z=3.6$, respectively. Using line ratios appropriate for high-redshift galaxies, we find these results to be in good agreement with those from the CO Power Spectrum Survey (COPSS). Adopting$\alpha_{\rm CO}=3.6\ M_{\odot}\ (\textrm{K}\ \textrm{km}\ \textrm{s}^{-1}\ \textrm{pc}^{2})^{-1}$, we estimate a cosmic molecular gas density of$\rho_{\textrm{H}_2}(z)\sim 10^{8}\ M_{\odot}\ \textrm{Mpc}^{-3}$between$z=1-3$.Comment: 25 pages, 12 figures, 6 tables, 2 appendices. Accepted for publication in Ap

Ultradeep Ks Imaging in the GOODS-N

We present an ultradeep Ks-band image that covers 0.5*0.5 deg^2 centered on the Great Observatories Origins Deep Survey-North (GOODS-N). The image reaches a 5 \sigma depth of Ks(AB) = 24.45 in the GOODS-N region, which is as deep as the GOODS-N Spitzer Infrared Array Camera (IRAC) 3.6 \mu m image. We present a new method of constructing IRAC catalogs that uses the higher spatial resolution Ks image and catalog as priors and iteratively subtracts fluxes from the IRAC images to estimate the IRAC fluxes. Our iterative method is different from the \chi^2 approach adopted by other groups. We verified our results using data taken in two different epochs of observations, as well as by comparing our colors with the colors of stars and with the colors derived from model spectral energy distributions (SEDs) of galaxies at various redshifts. We make available to the community our WIRCam Ks-band image and catalog (94951 objects in 0.25 deg^2), the Interactive Data Language (IDL) pipeline used for reducing the WIRCam images, and our IRAC 3.6 to 8.0 \mu m catalog (16950 objects in 0.06 deg^2 at 3.6 \mu m). With this improved Ks and IRAC catalog and a large spectroscopic sample from our previous work, we study the color-magnitude and color-color diagrams of galaxies. We compare the effectiveness of using Ks and IRAC colors to select active galactic nuclei (AGNs) and galaxies at various redshifts. We also study a color selection of z = 0.65--1.2 galaxies using the Ks, 3.6 \mu m, and 4.5 \mu m bands.Comment: Accepted for publication on ApJS. Online data are availabl

Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum: A case series and systematic literature review

BACKGROUND: Heterotopic pancreas (HP) is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract. While the majority of heterotopic pancreatic lesions are asymptomatic, many manifest severe clinical symptoms which require surgical or endoscopic intervention. Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature. The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease. AIM: To classify the common clinical manifestations of heterotopic pancreas. METHODS: A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018. Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location. Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated. These were compared to a systematic review of the literature utilizing PubMed and Embase searches for papers pertaining to heterotopic pancreas. Publications describing symptomatic presentation of HP were selected for review. Information including demographics, symptoms, presentation and treatment were compiled and analyzed. RESULTS: Twenty-nine patient were identified with HP at a single center, with six of these identified has having clinical symptoms. Clinical manifestations included, gastrointestinal bleeding, gastric ulceration with/without perforation, pancreatitis, and gastric outlet obstruction. Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients. Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients. The majority of patients presented with abdominal pain (67%) combined with one of the following clinical categories: (1) Dyspepsia, (n = 445, 48%); (2) Pancreatitis (n = 260, 28%); (3) Gastrointestinal bleeding (n = 80, 9%); and (4) Gastric outlet obstruction (n = 80, 9%). The majority of cases (n = 832, 90%) underwent surgical or endoscopic resection with 85% reporting resolution or improvement in their symptoms. CONCLUSION: Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract. Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation

Observations of enhanced extreme ultraviolet continua during an X-class solar flare using <i>SDO</i>/EVE.

Observations of extreme-ultraviolet (EUV) emission from an X-class solar flare that occurred on 2011 February 15 at 01:44 UT are presented, obtained using the EUV Variability Experiment (EVE) onboard the Solar Dynamics Observatory. The complete EVE spectral range covers the free-bound continua of H I (Lyman continuum), He I, and He II, with recombination edges at 91.2, 50.4, and 22.8 nm, respectively. By fitting the wavelength ranges blue-ward of each recombination edge with an exponential function, lightcurves of each of the integrated continua were generated over the course of the flare, as well as emission from the free-free continuum (6.5-37 nm). The He II 30.4 nm and Lyman-alpha 121.6 nm lines, and soft X-ray (0.1-0.8 nm) emission from GOES are also included for comparison. Each free-bound continuum was found to have a rapid rise phase at the flare onset similar to that seen in the 25-50 keV lightcurves from RHESSI, suggesting that they were formed by recombination with free electrons in the chromosphere. However, the free-free emission exhibited a slower rise phase seen also in the soft X-ray emission from GOES, implying a predominantly coronal origin. By integrating over the entire flare the total energy emitted via each process was determined. We find that the flare energy in the EVE spectral range amounts to at most a few per cent of the total flare energy, but EVE gives us a first comprehensive look at these diagnostically important continuum components.Comment: 6 pages, 3 figures, 1 table. Accepted to ApJ Letter

Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment

BACKGROUND: Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as well as inter-person germline and somatic variation. To address these gaps, we developed an autologous system that models the tumor microenvironment (TME) from individual patients with solid tumors. METHOD: With patient-derived bone marrow hematopoietic stem and progenitor cells (HSPCs), we engrafted a patient\u27s hematopoietic system in MISTRG6 mice, followed by transfer of patient-derived xenograft (PDX) tissue, providing a fully genetically matched model to recapitulate the individual\u27s TME. We used this system to prospectively study tumor-immune interactions in patients with solid tumor. RESULTS: Autologous PDX mice generated innate and adaptive immune populations; these cells populated the TME; and tumors from autologously engrafted mice grew larger than tumors from non-engrafted littermate controls. Single-cell transcriptomics revealed a prominent vascular endothelial growth factor A (VEGFA) signature in TME myeloid cells, and inhibition of human VEGF-A abrogated enhanced growth. CONCLUSIONS: Humanization of the interleukin 6 locus in MISTRG6 mice enhances HSPC engraftment, making it feasible to model tumor-immune interactions in an autologous manner from a bedside bone marrow aspirate. The TME from these autologous tumors display hallmarks of the human TME including innate and adaptive immune activation and provide a platform for preclinical drug testing

SDSS-IV MaNGA : spatial evolution of star formation triggered by galaxy interactions

Galaxy interaction is considered a key driver of galaxy evolution and star formation (SF) history. In this paper, we present an empirical picture of the radial extent of interaction-triggered SF along the merger sequence. The samples under study are drawn from the integral field spectroscopy survey SDSS-IV MaNGA, including 205 star-forming galaxies in pairs/mergers and ~1350 control galaxies. For each galaxy in pairs, the merger stage is identified according to its morphological signatures: incoming phase, at first pericenter passage, at apocenter, in merging phase, and in final coalescence. The effect of interactions is quantified by the global and spatially resolved SF rate (SFR) relative to the SFR of a control sample selected for each individual galaxy (Δlog SFR and Δlog sSFR(r), respectively). Analysis of the radial Δlog sSFR(r) distributions shows that galaxy interactions have no significant impact on Δlog sSFR(r) during the incoming phase. Right after the first pericenter passage, the radial Δlog sSFR(r) profile decreases steeply from enhanced to suppressed activity for increasing galactocentric radius. Later on, SF is enhanced on a broad spatial scale out to the maximum radius we explore (~6.7 kpc) and the enhancement is in general centrally peaked. The extended SF enhancement is also observed for systems at their apocenters and in the coalescence phase, suggesting that interaction-triggered SF is not restricted to the central region of a galaxy. Further explorations of a wide range in parameter space of merger configurations (e.g., mass ratio) are required to constrain the whole picture of interaction-triggered S

Memory-like differentiation enhances NK cell responses to melanoma

PURPOSE: Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies are needed to enhance NK-cell antitumor responses. Cytokine-induced memory-like (ML) differentiation overcomes many barriers in the NK-cell therapeutics field, resulting in potent cytotoxicity and enhanced cytokine production against blood cancer targets. However, the preclinical activity of ML NK against solid tumors remains largely undefined. EXPERIMENTAL DESIGN: Phenotypic and functional alterations of blood and advanced melanoma infiltrating NK cells were evaluated using mass cytometry. ML NK cells from healthy donors (HD) and patients with advanced melanoma were evaluated for their ability to produce IFNγ and kill melanoma targets RESULTS: NK cells in advanced melanoma exhibited a decreased cytotoxic potential compared with blood NK cells. ML NK cells differentiated from HD and patients with advanced melanoma displayed enhanced IFNγ production and cytotoxicity against melanoma targets. This included ML differentiation enhancing melanoma patients\u27 NK-cell responses against autologous targets. The ML NK-cell response against melanoma was partially dependent on the NKG2D- and NKp46-activating receptors. Furthermore, in xenograft NSG mouse models, human ML NK cells demonstrated superior control of melanoma, compared with conventional NK cells. CONCLUSIONS: Blood NK cells from allogeneic HD or patients with advanced melanoma can be differentiated into ML NK cells for use as a novel immunotherapeutic treatment for advanced melanoma, which warrants testing in early-phase clinical trials

Representations of sport in the revolutionary socialist press in Britain, 1988–2012

This paper considers how sport presents a dualism to those on the far left of the political spectrum. A long-standing, passionate debate has existed on the contradictory role played by sport, polarised between those who reject it as a bourgeois capitalist plague and those who argue for its reclamation and reformation. A case study is offered of a political party that has consistently used revolutionary Marxism as the basis for its activity and how this party, the largest in Britain, addresses sport in its publications. The study draws on empirical data to illustrate this debate by reporting findings from three socialist publications. When sport did feature it was often in relation to high profile sporting events with a critical tone adopted and typically focused on issues of commodification, exploitation and alienation of athletes and supporters. However, readers’ letters, printed in the same publications, revealed how this interpretation was not universally accepted, thus illustrating the contradictory nature of sport for those on the far left