PERANCANGAN PROSEDUR PENERIMAAN KAS DALAM MENINGKATKAN PENGENDALIAN INTEREN PADA BENGKEL MOTOR APFAH

The purpose of this study was to determine the cash receipts procedures in the increase of internal controls on a motorcycle Workshop Apfah. The method of analysis used in the conduct of research is by using the method of Qualitative Descriptive analysis. The results of the research that has been done shows that 1. The system of cash receipts that are in a Motor Workshop Apfah not support the operation of the company. It can be seen from the absence of a separation of responsibilities between the functions related to the system of cash receipts. 2. The design of the cash receipts Bengkel Motor Apfah is based on the procedure-a procedure that has been running in the company. The design is made, among others: the design of organizational structure, design flow chart document. In the design flow chart documents the researcher changes in certain procedures in the system and do the addition of on the documents that exist in the system of cash receipts of the company.Keywords: The Design Procedure, Cash Receipts, Internal Contro

Fungi of Madre De Dios

Elevated temperatures and high moisture in tropical ecosystems lead to rapid nutrient cycling and turnover. Therefore, decomposers serve vital roles in biodiversity protection within tropical climates. This quick turnover makes identification of fungi extremely difficult since existing fungi identification lists are not exhaustive and new species are likely appearing annually, causing a lack of fungi knowledge. Citizen science plays a critical role in combating this deficit by increasing the sightings and photographs of fungi in tropical ecosystems. With more amateur data, scientists will have more resources and incentives to genotypically sequence tropical fungi to determine rates of speciation and evolution

Multiple Group Membership and Well-Being: Is There Always Strength in Numbers?

This is the final version of the article. Available from Frontiers Media via the DOI in this record.The research materials supporting this publication can be accessed by contacting Dr. Anders Larrabee Sønderlund at [email protected] growing body of research points to the value of multiple group memberships for individual well-being. However, much of this work considers group memberships very broadly and in terms of number alone. We conducted two correlational studies exploring how the relationship between multiple group membership and well-being is shaped by (a) the complexity of those groups within the overall self-concept (i.e., social identity complexity: SIC), and (b) the perceived value and visibility of individual group memberships to others (i.e., stigma). Study 1 (N = 112) found a positive relationship between multiple group membership and well-being, but only for individuals high in SIC. This effect was mediated by perceived identity expression and access to social support. Study 2 (N = 104) also found that multiple group memberships indirectly contributed to well-being via perceived identity expression and social support, as well as identity compatibility and perceived social inclusion. But, in this study the relationship between multiple group memberships and well-being outcomes was moderated by the perceived value and visibility of group memberships to others. Specifically, possessing multiple, devalued and visible group memberships compromised well-being relative to multiple valued group memberships, or devalued group memberships that were invisible. Together, these studies suggest that the benefits of multiple group membership depend on factors beyond their number. Specifically, the features of group memberships, individually and in combination, and the way in which these guide self-expression and social action, determine whether these are a benefit or burden for individual well-being

The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4

Spy1A is a cyclin-like protein required for progression through the G(1)/S phase of the cell cycle. Elevated Spy1A protein levels have been implicated in tumorigenesis and are attributed to overriding the DNA damage response and enhancing cell proliferation. Understanding how Spy1A is produced and degraded is essential in resolving how it contributes to normal and abnormal growth processes. Herein, we demonstrate that Spy1A is degraded in a cell cycle-dependent manner during mitosis via the ubiquitin-proteasome system. We have resolved the E3 ligase and essential phosphorylation sites mediating Spy1A degradation. Furthermore, we have determined that non-degradable forms of Spy1A do not trigger cell cycle arrest but, rather, contribute to uncontrolled cell growth. Further investigation into the regulation of Spy1A may reveal novel strategies for understanding the etiology and progression of specific growth disorders

Towards a model for monitoring public services projects in Saudi Arabia

Information and communication technology (ICT) has been adopted by many governments around the world in the form of e-government to facilitate service delivery to the public. Saudi Arabia is an example of such a country that has adopted technology with these aims, but there is a failure in enabling the engagement of citizens with government to deliver public services projects with assured quality standards. The failings are blamed on the system's lack of support for stakeholder oversight. In light of these inadequacies, more effective monitoring of project construction and project implementation is required in order to improve public service quality from a long-term perspective. Fixes have been proposed to the lack of two-way communication between citizens and the government by inviting feedback from citizens through social media and other communication channels, however, a cohesive overarching model that enables the engagement of citizens with government projects has yet to be devised. There is a clear need for a model that can be applied to design official systems to facilitate consultation between the government and the public and to invite feedback from key stakeholders throughout each stage of the project lifecycle. This paper proposes a conceptual model to facilitate citizens in monitoring the quality of public services and the progress of public service projects. It is designed based on an in-depth analysis of the available systems on the market, e-participation studies and theoretical work presented in the literature. The paper also recommends technologies and features that will facilitate the implementation of the model in different contexts

Novel muon imaging techniques

Owing to the high penetrating power of high-energy cosmic ray muons, muon imaging techniques can be used to image large bulky objects, especially objects with heavy shielding. Muon imaging systems work just like CT scanners in the medical imaging field—that is, they can reveal information inside of a target. There are two forms of muon imaging techniques: muon absorption imaging and muon multiple scattering imaging. The former is based on the flux attenuation of muons, and the latter is based on the multiple scattering of muons in matter. The muon absorption imaging technique is capable of imaging very large objects such as volcanoes and large buildings, and also smaller objects like spent fuel casks; the muon multiple scattering imaging technique is best suited to inspect smaller objects such as nuclear waste containers. Muon imaging techniques can be applied in a broad variety of fields, i.e. from measuring the magma thickness of volcanoes to searching for secret cavities in pyramids, and from monitoring the borders of countries checking for special nuclear materials to monitoring the spent fuel casks for nuclear safeguards applications. In this paper, the principles of muon imaging are reviewed. Image reconstruction algorithms such as Filtered Back Projection and Maximum Likelihood Expectation Maximization are discussed. The capability of muon imaging techniques is demonstrated through a Geant4 simulation study for imaging a nuclear spent fuel cask

Novel antiinflammatory biologics shaped by parasite-host coevolution

Parasitic helminth infections, while a major cause of neglected tropical disease burden, negatively correlate with the incidence of immune-mediated inflammatory diseases such as inflammatory bowel diseases (IBD). To evade expulsion, helminths have developed sophisticated mechanisms to regulate their host\u27s immune responses. Controlled experimental human helminth infections have been assessed clinically for treating inflammatory conditions; however, such a radical therapeutic modality has challenges. An alternative approach is to harness the immunomodulatory properties within the worm\u27s excretory-secretory (ES) complement, its secretome. Here, we report a biologics discovery and validation pipeline to generate and screen in vivo a recombinant cell-free secretome library of helminth-derived immunomodulatory proteins. We successfully expressed 78 recombinant ES proteins from gastrointestinal hookworms and screened the crude in vitro translation reactions for anti-IBD properties in a mouse model of acute colitis. After statistical filtering and ranking, 20 proteins conferred significant protection against various parameters of colitis. Lead candidates from distinct protein families, including annexins, transthyretins, nematode-specific retinol-binding proteins, and SCP/TAPS were identified. Representative proteins were produced in mammalian cells and further validated, including ex vivo suppression of inflammatory cytokine secretion by T cells from IBD patient colon biopsies. Proteins identified herein offer promise as novel, safe, and mechanistically differentiated biologics for treating the globally increasing burden of inflammatory diseases

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes.

OBJECTIVES: The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND: Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization. METHODS: The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated. Patients were stratified according to revascularization decision making on the basis of iFR or FFR and to clinical presentation (SAP or ACS). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization at 1 year. RESULTS: Coronary revascularization was deferred in 2,130 patients. Deferral was performed in 1,117 patients (50%) in the iFR group and 1,013 patients (45%) in the FFR group (p < 0.01). At 1 year, the MACE rate in the deferred population was similar between the iFR and FFR groups (4.12% vs. 4.05%; fully adjusted hazard ratio: 1.13; 95% confidence interval: 0.72 to 1.79; p = 0.60). A clinical presentation with ACS was associated with a higher MACE rate compared with SAP in deferred patients (5.91% vs. 3.64% in ACS and SAP, respectively; fully adjusted hazard ratio: 0.61 in favor of SAP; 95% confidence interval: 0.38 to 0.99; p = 0.04). CONCLUSIONS: Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used to assess physiological significance. In deferred patients presenting with ACS, the event rate was significantly increased compared with SAP at 1 year.info:eu-repo/semantics/publishedVersio