Water Availability and Deformation Processes in Smectite-Rich Gouges During Seismic Slip

Smectite clays occur in subduction zone fault cores at shallow depth (approximately 1 km; e.g., Japan Trench) and landslide d\ue9collements (e.g., Vajont, Italy, 1963). The availability of pore fluids affects the likelihood that seismic slip propagates from deeper to shallow fault depths or that a landslide accelerates to its final collapse. To investigate the deformation processes active during seismic faulting we performed friction experiments with a rotary machine on 2-mm-thick smectite-rich gouge layers (70/30 wt % Ca-montmorillonite/opal) sheared at 5-MPa normal stress, at slip rates of 0.001, 0.01, 0.1, and 1.3 m/s, and total displacement of 3 m. Experiments were performed on predried gouges under vacuum, under room humidity and under partly saturated conditions. The fault shear strength measured in the experiments was included in a one-dimensional numerical model incorporating frictional heating, thermal, and thermochemical pressurization. Quantitative X-ray powder diffraction and scanning electron microscopy investigations were performed on pristine and deformed smectite-rich gouges. Under dry conditions, cataclasis and amorphization dominated at slip rates of 0.001\u20130.1 m/s, whereas grain size sensitive flow and, under vacuum, frictional melting occurred at fast slip rates (1.3 m/s). Under partly saturated conditions, frictional slip in a smectite foliation occurred in combination with pressurization of water by shear-enhanced compaction and, for V = 0.01\u20131.3 m/s, with thermal pressurization. Pseudotachylytes, the only reliable microstructural markers for seismic slip, formed only with large frictional power (>2 MW/m2), which could be achieved at shallow depth with high slip rates, or, at depth, with high shear stress in dehydrated smectites

An assessment of anxiety levels in dyslexic students in higher education

Background: It has long been hypothesized that children with learning disabilities, including dyslexia, may be highly vulnerable to emotional consequences such as anxiety. However, research has centred on school aged children. Aims: The present study aimed to clarify these findings with dyslexic students in higher education. Samples: 16 students with dyslexia were compared to 16 students with no history of learning difficulties. Methods: Students were asked to complete a verbal questionnaire concerning trait anxiety levels. They were then told that they would be given a timed reading test and their state anxiety levels were measured using the State‐Trait Anxiety Inventory (STAI; Spielberger, Gorsuch, & Lushene, 1983). Finally their reading was assessed using the Test of Word Reading Efficiency (Torgesen, Wagner & Rashotte, 1999). Results: Dyslexic students showed slower reading speeds than controls. They also had higher levels of state anxiety and elevated levels of academic and social, but not appearance anxiety. Conclusions: Dyslexic students in higher education show anxiety levels that are well above what is shown by students without learning difficulties. This anxiety is not limited to academic tasks but extends to many social situations. It is proposed that assessment of emotional well‐being should form part of the assessment of need for dyslexic students entering higher education

Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance?

The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacist’s roles and responsibilities have become more clinic and patient focused. In the community (primary care), pharmacists have become important providers of healthcare as Western healthcare policy advocates patient self-care. This has resulted in pharmacists taking on greater responsibility in managing minor illness and the delivery of public health interventions. These roles require pharmacists to more fully use their clinical skills, and often involve diagnosis and therapeutic management. Community pharmacists are now, more than ever before, in a position to identify, record and report medication safety incidents. However, current research suggests that diagnostic ability of community pharmacists is questionable and they infrequently report to local or national schemes. The aim of this paper is to highlight current practice and suggest ways in which community pharmacy can more fully contribute to patient safety

Intake characteristics of perennial ryegrass varieties when grazed by yearling beef cattle under rotational grazing management

Four intermediate-heading perennial ryegrass (Lolium perenne L.) varieties, which in previous studies had been associated with high- or low-intake characteristics when swards containing them had been continuously stocked with sheep, were sown as monocultures. They were rotationally grazed, using 1-d paddocks, with core groups of four yearling Simmental x Holstein beef heifers in 2002 and 2003 and ingestive and ruminative behaviour, and sward factors, were measured. There were two diploid (Belramo and Glen) and one tetraploid (Rosalin) perennial ryegrass varieties and one tetraploid hybrid (Lolium x boucheanum Kunth) (AberExcel) variety. Intake rate (IR) was significantly higher in August 2003 for heifers grazing Glen than those grazing Belramo [27.5 vs. 20.6 g dry matter (DM) min(-1); P = 0.019], but there were no significant differences between varieties in two other measurement periods. This is in contrast to previous results with sheep when IR were significantly higher for Glen than Belramo and for AberExcel than Rosalin. Total jaw movement rates during grazing were significantly higher for heifers on the tetraploid swards than those on the diploid swards (87.7 vs. 83.6 jaw movements min(-1); P = 0.023) in September 2002. Ruminating time was significantly lower for heifers on the tetraploid swards than those on the diploid swards (453 vs. 519 min 24 h(-1); P = 0.012) in July 2002. Digestibility of grass snips was significantly higher on the tetraploid than the diploid swards [697 vs. 680 g digestible organic matter (DOM) kg(-1) DM; P = 0.042] in September 2003 and, within diploids, was significantly higher for Glen than Belramo (696 vs. 663 g DOM kg(-1) DM; P = 0.014). There were significant differences in sheath tube and leaf lengths and in the population density of tillers between and within ploidies, which might have been expected to have influenced intake characteristics, but this was not generally found under rotational grazing with cattle. In order to separate the effects of defoliation interval from those of grazing style of the different ruminant species, it is suggested that grass variety evaluations using continuously stocked cattle swards are required

Vertical sleeve gastrectomy lowers SGLT2/Slc5a2 expression in the mouse kidney

Bariatric surgery improves glucose homeostasis but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium glucose cotransporter-2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG). Indicating an important contribution of altered cotransporter expression to the impact of surgery, inactivation of the SGLT2/Slc5a2 gene by CRISPR/Cas9 attenuated the effects of VSG, with glucose excursions following intraperitoneal injection lowered by ∼30% in wild-type mice but by ∼20% in SGLT2 null animals. The effects of the SGLT2 inhibitor dapaglifozin were similarly blunted by surgery. Unexpectedly, effects of dapaglifozin were still observed in SGLT2 null mice, consistent with the existence of metabolically beneficial off-target effects of SGLT2 inhibitors. Thus, we describe a new mechanism involved in mediating the glucose lowering effects of bariatric surgery

Cultural basis of social ‘deficits’ in autism spectrum disorders

There is very little research that specifically looks at how autism spectrum disorders are perceived in various communities. This qualitative research was conducted with parents who had children on the autistic spectrum belonging to four different ethnic communities (White British, Somali, West African and South Asian- 63 in total) and living in the UK. The study found that the importance that the parents give to various social skills varied on the basis of their cultural background and the gender of the parent. This is an important aspect to consider while providing support and services to individuals on the autism spectrum and their family members if the services have to be appropriate for their needs. This consideration would also enable the individuals on the autism spectrum to develop appropriate social skills required within their cultural groups. This is a preliminary study and further research on the topic is required

The Effects of Negative Legacies on the Adjustment of Parentally Bereaved Children and Adolescents

This is a report of a qualitative analysis of a sample of bereaved families in which one parent died and in which children scored in the clinical range on the Child Behavior Check List. The purpose of this analysis was to learn more about the lives of these children. They were considered to be at risk of developing emotional and behavioral problems associated with the death. We discovered that many of these “high risk” children had a continuing bond with the deceased that was primarily negative and troubling for them in contrast to a comparison group of children not at risk from the same study. Five types of legacies, not mutually exclusive, were identified: health related, role related, personal qualities, legacy of blame, and an emotional legacy. Coping behavior on the part of the surviving parent seemed to make a difference in whether or not a legacy was experienced as negative

Measuring commissioners’ willingness-to-pay for community based childhood obesity prevention programmes using a discrete choice experiment

Background: In the UK, rates of childhood obesity remain high. Community based programmes for child obesity prevention are available to be commissioned by local authorities. However, there is a lack of evidence regarding how programmes are commissioned and which attributes of programmes are valued most by commissioners. The aim of this study was to determine the factors that decision-makers prioritise when commissioning programmes that target childhood obesity prevention. Methods: An online discrete choice experiment (DCE) was used to survey commissioners and decision makers in the UK to assess their willingness-to-pay for childhood obesity programmes. Results: A total of 64 commissioners and other decision makers completed the DCE. The impact of programmes on behavioural outcomes was prioritised, with participants willing to pay an extra £16,600/year if average daily fruit and vegetable intake increased for each child by one additional portion. Participants also prioritised programmes that had greater number of parents fully completing them, and were willing to pay an extra £4810/year for every additional parent completing a programme. The number of parents enrolling in a programme (holding the number completing fixed) and hours of staff time required did not significantly influence choices. Conclusions: Emphasis on high programme completion rates and success increasing children’s fruit and vegetable intake has potential to increase commissioning of community based obesity prevention programmes