Black chokeberry fruit polyphenols: A valuable addition to reduce lipid oxidation of muffins containing xylitol

The study aimed at assessing effects of black chokeberry polyphenol extract (ChPE) added (0.025–0.075%) to xylitol-containing muffins to reduce lipid oxidation, especially in preventing degradation of hydroperoxides throughout the storage period. Among polyphenolic compounds (3092 mg/100 g in total) in ChPE, polymeric procyanidins were the most abundant (1564 mg/100 g). ChPE addition resulted in a significantly increased capacity of scavenging free radicals and markedly inhibited hydroperoxides decomposition, as reflected by low anisidine values (AnV: 3.25–7.52) throughout the storage. On the other hand, sucrose-containing muffins had increased amounts of primary lipid oxidation products and differed significantly from other samples in conjugated diene hydroperoxides (CD values), which was in accordance with the decrease of C18:2 9c12c in those muffins after storage. In addition, sucrose-containing muffins were found to be those with the highest level of contamination with toxic carbonyl lipid oxidation products. Throughout the storage, no yeast or moulds contamination were found in higher enriched muffins. The incorporation of polyphenols to xylitol-containing muffins resulted in preventing decomposition of polyunsaturated fatty acids (PUFAs), and in reducing the content of some toxic aldehydes. ChPE could be regarded as a possible solution to xylitol-containing muffins to extend their shelf life. The results support the use of xylitol in muffin manufacture as being favourable in terms of suitability for diabetics

Discovery of a high state AM CVn binary in the Galactic Bulge Survey

We report on the discovery of a hydrogen-deficient compact binary (CXOGBS J175107.6-294037) belonging to the AM CVn class in the Galactic Bulge Survey. Deep archival X-ray observations constrain the X-ray positional uncertainty of the source to 0.57 arcsec, and allow us to uniquely identify the optical and UV counterpart. Optical spectroscopic observations reveal the presence of broad, shallow He i absorption lines while no sign of hydrogen is present, consistent with a high state system. We present the optical lightcurve from Optical Gravitational Lensing Experiment monitoring, spanning 15 years. It shows no evidence for outbursts; variability is present at the 0.2 mag level on timescales ranging from hours to weeks. A modulation on a timescale of years is also observed. A Lomb-Scargle analysis of the optical lightcurves shows two significant periodicities at 22.90 and 23.22 min. Although the physical interpretation is uncertain, such timescales are in line with expectations for the orbital and superhump periods. We estimate the distance to the source to be between 0.5 - 1.1 kpc. Spectroscopic follow-up observations are required to establish the orbital period, and to determine whether this source can serve as a verification binary for the eLISA gravitational wave mission.Comment: Accepted for publication in MNRAS Letter

Gaia transients in galactic nuclei

The high spatial resolution and precise astrometry and photometry of the Gaia mission should make it particularly apt at discovering and resolving transients occurring in, or near, the centres of galaxies. Indeed, some nuclear transients are reported by the Gaia Science Alerts (GSA) team, but not a single confirmed Tidal Disruption Event has been published. In order to explore the sensitivity of GSA, we performed an independent and systematic search for nuclear transients using Gaia observations. Our transient search is driven from an input galaxy catalogue (derived from the Sloan Digital Sky Survey Release 12). We present a candidate detection metric which is independent from the existing GSA methodology, to see if Gaia Alerts are biased against the discovery of nuclear transients, and in particular which steps may have an impact. Our technique does require significant manual vetting of candidates, making implementation in the GSA system impractical for daily operations, although it could be run weekly, which for month-to-year long transients would make a scientifically valuable addition. Our search yielded ~480 nuclear transients, 5 of which were alerted and published by GSA. The list of (in some cases ongoing) transients includes candidates for events related to enhanced accretion onto a super-massive black hole and TDEs. An implementation of the detection methodology and criteria used in this paper as an extension of GSA could open up the possibility for Gaia to fulfil the role as a main tool to find transient nuclear activity as predicted in the literature.Comment: MNRAS accepted; full Table 2 attache

Protein folding on the ribosome studied using NMR spectroscopy

NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution. In recent years NMR methods have also been developed to study protein folding as it might occur within the cell, in a de novo manner, by observing the folding of nascent polypeptides in the process of emerging from the ribosome during synthesis. Despite the 2.3 MDa molecular weight of the bacterial 70S ribosome, many nascent polypeptides, and some ribosomal proteins, have sufficient local flexibility that sharp resonances may be observed in solution-state NMR spectra. In providing information on dynamic regions of the structure, NMR spectroscopy is therefore highly complementary to alternative methods such as X-ray crystallography and cryo-electron microscopy, which have successfully characterized the rigid core of the ribosome particle. However, the low working concentrations and limited sample stability associated with ribosome-nascent chain complexes means that such studies still present significant technical challenges to the NMR spectroscopist. This review will discuss the progress that has been made in this area, surveying all NMR studies that have been published to date, and with a particular focus on strategies for improving experimental sensitivity

Electromagnetic counterparts to gravitational wave events from Gaia

The recent discoveries of gravitational wave events and in one case also its electromagnetic (EM) counterpart allow us to study the Universe in a novel way. The increased sensitivity of the LIGO and Virgo detectors has opened the possibility for regular detections of EM transient events from mergers of stellar remnants. Gravitational wave sources are expected to have sky localisation up to a few hundred square degrees, thus Gaia as an all-sky multi-epoch photometric survey has the potential to be a good tool to search for the EM counterparts. In this paper we study the possibility of detecting EM counterparts to gravitational wave sources using the Gaia Science Alerts system. We develop an extension to current used algorithms to find transients and test its capabilities in discovering candidate transients on a sample of events from the observation periods O1 and O2 of LIGO and Virgo. For the gravitational wave events from the current run O3 we expect that about 16 (25) per cent should fall in sky regions observed by Gaia 7 (10) days after gravitational wave. The new algorithm will provide about 21 candidates per day from the whole sky