Quantal calcium release and calcium entry in the pancreatic acinar cell.

In the past decade, there have been remarkable advances in our understanding of the calcium messenger system that mediates the effects of various agonists. The purpose of the present article is to describe two areas of current interest in the calcium signaling field--quantal calcium release and calcium entry into the cell--using the pancreatic acinar cell as a model. Proposed mechanisms describing these phenomena and the role they play in the kinetics of calcium movements in the cell are discussed

Use of record-linkage to handle non-response and improve alcohol consumption estimates in health survey data: a study protocol

<p>Introduction: Reliable estimates of health-related behaviours, such as levels of alcohol consumption in the population, are required to formulate and evaluate policies. National surveys provide such data; validity depends on generalisability, but this is threatened by declining response levels. Attempts to address bias arising from non-response are typically limited to survey weights based on sociodemographic characteristics, which do not capture differential health and related behaviours within categories. This project aims to explore and address non-response bias in health surveys with a focus on alcohol consumption.</p> <p>Methods and analysis: The Scottish Health Surveys (SHeS) aim to provide estimates representative of the Scottish population living in private households. Survey data of consenting participants (92% of the achieved sample) have been record-linked to routine hospital admission (Scottish Morbidity Records (SMR)) and mortality (from National Records of Scotland (NRS)) data for surveys conducted in 1995, 1998, 2003, 2008, 2009 and 2010 (total adult sample size around 40 000), with maximum follow-up of 16 years. Also available are census information and SMR/NRS data for the general population. Comparisons of alcohol-related mortality and hospital admission rates in the linked SHeS-SMR/NRS with those in the general population will be made. Survey data will be augmented by quantification of differences to refine alcohol consumption estimates through the application of multiple imputation or inverse probability weighting. The resulting corrected estimates of population alcohol consumption will enable superior policy evaluation. An advanced weighting procedure will be developed for wider use.</p> <p>Ethics and dissemination: Ethics approval for SHeS has been given by the National Health Service (NHS) Multi-Centre Research Ethics Committee and use of linked data has been approved by the Privacy Advisory Committee to the Board of NHS National Services Scotland and Registrar General. Funding has been granted by the MRC. The outputs will include four or five public health and statistical methodological international journal and conference papers.</p&gt

No classical limit of quantum decay for broad states

Though the classical treatment of spontaneous decay leads to an exponential decay law, it is well known that this is an approximation of the quantum mechanical result which is a non-exponential at very small and large times for narrow states. The non exponential nature at large times is however hard to establish from experiments. A method to recover the time evolution of unstable states from a parametrization of the amplitude fitted to data is presented. We apply the method to a realistic example of a very broad state, the sigma meson and reveal that an exponential decay is not a valid approximation at any time for this state. This example derived from experiment, shows the unique nature of broad resonances

Detection of super-high-frequency partial discharge by using neural networks

A system has been developed for the detection of super-high-frequency (SHF) partial discharge (PD) at frequencies up to 6 GHz. The system consists of three antennas for capturing PDs and a fast digital oscilloscope for sampling data. One of the antennas is a disk-cone antenna with frequency range below 710 MHz. The other two half TEM horn antennas have been designed and constructed for the frequency range 716 MHz - 5 GHz. To extend the frequency range up to 6 GHz, a methodology has been developed by compensating amplitude-response to frequency-magnitude. The compensation is realised by using multilayer feed-forward neural networks to equalise on amplitude-response. A direct sampling method is used to log the captured PD data. This PD detection system has been implemented to measure PDs at a 400 kV electrical substation (Strathaven, Scottish Power Ltd)

StyloThai: A scalable framework for stylometric authorship identification of Thai documents

This is an accepted manuscript of an article published by ACM in ACM Transactions on Asian and Low-Resource Language Information Processing in January 2020, available online: https://doi.org/10.1145/3365832 The accepted version of the publication may differ from the final published version.© 2020 Association for Computing Machinery. All rights reserved. Authorship identification helps to identify the true author of a given anonymous document from a set of candidate authors. The applications of this task can be found in several domains, such as law enforcement agencies and information retrieval. These application domains are not limited to a specific language, community, or ethnicity. However, most of the existing solutions are designed for English, and a little attention has been paid to Thai. These existing solutions are not directly applicable to Thai due to the linguistic differences between these two languages. Moreover, the existing solution designed for Thai is unable to (i) handle outliers in the dataset, (ii) scale when the size of the candidate authors set increases, and (iii) perform well when the number of writing samples for each candidate author is low.We identify a stylometric feature space for the Thai authorship identification task. Based on our feature space, we present an authorship identification solution that uses the probabilistic k nearest neighbors classifier by transforming each document into a collection of point sets. Specifically, this document transformation allows us to (i) use set distance measures associated with an outlier handling mechanism, (ii) capture stylistic variations within a document, and (iii) produce multiple predictions for a query document. We create a new Thai authorship identification corpus containing 547 documents from 200 authors, which is significantly larger than the corpus used by the existing study (an increase of 32 folds in terms of the number of candidate authors). The experimental results show that our solution can overcome the limitations of the existing solution and outperforms all competitors with an accuracy level of 91.02%. Moreover, we investigate the effectiveness of each stylometric features category with the help of an ablation study. We found that combining all categories of the stylometric features outperforms the other combinations. Finally, we cross compare the feature spaces and classification methods of all solutions. We found that (i) our solution can scale as the number of candidate authors increases, (ii) our method outperforms all the competitors, and (iii) our feature space provides better performance than the feature space used by the existing study.The research was partially supported by the Digital Economy Promotion Agency (project# MP-62- 0003); and Thailand Research Fund and Office of the Higher Education Commission (MRG6180266).Published versio

Observing the spin of a free electron

Long ago, Bohr, Pauli, and Mott argued that it is not, in principle, possible to measure the spin components of a free electron. One can try to use a Stern-Gerlach type of device, but the finite size of the beam results in an uncertainty of the splitting force that is comparable with the gradient force. The result is that no definite spin measurement can be made. Recently there has been a revival of interest in this problem, and we will present our own analysis and quantum-mechanical wave-packet calculations which suggest that a spin measurement is possible for a careful choice of initial conditions

Relativistic precession and spin dynamics of an elliptic Rydberg wave packet

Time evolution of wave packets built from the eigenstates of the Dirac equation for a hydrogenic system is considered. We investigate the space and spin motion of wave packets which, in the non-relativistic limit, are stationary states with a probability density distributed uniformly along the classical, elliptical orbit (elliptic WP). We show that the precession of such a WP, due to relativistic corrections to the energy eigenvalues, is strongly correlated with the spin motion. We show also that the motion is universal for all hydrogenic systems with an arbitrary value of the atomic number Z.Comment: Latex2e, uses IOP style files (included), 10 pages, 5 jpg figures, 1 postscript figure. Relation between precession time and radiative liftime added (eq.(12)). Accepted for publication in J. Phys.