All Split Helicity Tree-Level Gluon Amplitudes

Recently a new recursion relation for tree-level gluon amplitudes in gauge theory has been discovered. We solve this recursion to obtain explicit formulas for the closed set of amplitudes with arbitrarily many positive and negative helicity gluons in a split helicity configuration. The solution admits a simple diagrammatic expansion in terms of zigzag diagrams. We comment on generalizations of this result.Comment: 15 pages, harvmac, v2: typos correcte

The dynamical Casimir effect in braneworlds

In braneworld cosmology the expanding Universe is realized as a brane moving through a warped higher-dimensional spacetime. Like a moving mirror causes the creation of photons out of vacuum fluctuations, a moving brane leads to graviton production. We show that, very generically, Kaluza-Klein (KK) particles scale like stiff matter with the expansion of the Universe and can therefore not represent the dark matter in a warped braneworld. We present results for the production of massless and KK gravitons for bouncing branes in five-dimensional anti de Sitter space. We find that for a realistic bounce the back reaction from the generated gravitons will be most likely relevant. This letter summarizes the main results and conclusions from numerical simulations which are presented in detail in a long paper [M.Ruser and R. Durrer, Phys. Rev. D 76, 104014 (2007), arXiv:0704.0790]Comment: misprints corrected, matches published versio

Dynamical Casimir effect for gravitons in bouncing braneworlds

We consider a two-brane system in a five-dimensional anti-de Sitter spacetime. We study particle creation due to the motion of the physical brane which first approaches the second static brane (contraction) and then recedes from it(expansion). The spectrum and the energy density of the generated gravitons are calculated. We show that the massless gravitons have a blue spectrum and that their energy density satisfies the nucleosynthesis bound with very mild constraints on the parameters. We also show that the Kaluza-Klein modes cannot provide the dark matter in an anti-de-Sitter braneworld. However, for natural choices of parameters, backreaction from the Kaluza-Klein gravitons may well become important. The main findings of this work have been published in the form of a Letter [R. Durrer and M. Ruser, Phys. Rev. Lett. 99, 071601 (2007), arXiv:0704.0756].Comment: 40 pages, 34 figures, improved and extended version, matches published versio

Alone but better off? Adult child migration and health of elderly parents in Moldova

Increasing labor migration and simultaneous aging of societies are two important demographic developments many poor countries face. Elderly people who are left behind may experience a decrease in welfare when their children migrate. This paper investigates the e ect of migration on various dimensions of elderly health using unique data from Moldova, which has one of the highest emigration rates in the world. We nd positive migration e ects on the body mass index (BMI), mobility and self-reported health. No e ects are found on depression and cognitive capacity. We trace these positive outcomes to an income e ect which leads to improvements in diet and a reallocation of time use from subsistence farming to leisure and sleep. These positive e ects seem to compensate the elderly for decreasing social contact with their migrant family members

Blood donor deferral policies across Europe and characteristics of men whohave sex with men screened for human immunodeficiency virus in bloodestablishments: data from the European Men-who-have-sex-with-men Internet Survey (EMIS).

BACKGROUND: The predominant mode of transmission of human immunodeficiency virus (HIV) in Europe is male-to-male transmission. Men who have sex with men (MSM) are deferred from donating blood in many countries, but nevertheless do donate blood. Based on data from 34 countries, we estimated the proportion of MSM screened for HIV in the context of a blood donation and identified individual factors associated with this HIV screening in order to propose possible public health interventions. MATERIALS AND METHODS: In 2010, the first European MSM Internet Survey (EMIS) collected self-reported data on HIV testing from >180,000 MSM in 38 European countries. Using logistic regression, demographic and behavioural factors associated with screening for HIV in blood establishments were identified. Stratified by European sub-region, we analysed the proportion of MSM screening in blood establishments by time elapsed since last negative HIV test. RESULTS: Donor eligibility criteria for MSM vary across Europe with most countries using permanent deferral. The Western region had the lowest (2%) proportion of MSM screened in blood establishments and the Northeastern region had the highest (14%). Being <25 years old, not disclosing sexual attraction to men, never having had anal intercourse with a man, having a female partner, living in a rural area, and certain European sub-regions or countries of residence increased the likelihood of being screened in blood establishments. DISCUSSION: In spite of deferral policies, MSM are screened for HIV in the context of blood donations. Gay-friendly testing services are rare in rural areas, and young men might be reluctant to disclose their sexual orientation. Recent developments, such as home sampling, might offer new testing possibilities for those not reached by established services yet wishing to know their HIV status. Donor selection procedures should be improved. Both interventions might help to further reduce the risk of transfusion-transmitted infections

On graviton production in braneworld cosmology

We study braneworlds in a five dimensional bulk, where cosmological expansion is mimicked by motion through AdS$_5$. We show that the five dimensional graviton reduces to the four dimensional one in the late time approximation of such braneworlds. Inserting a fixed regulator brane far from the physical brane, we investigate quantum graviton production due to the motion of the brane. We show that the massive Kaluza-Klein modes decouple completely from the massless mode and they are not generated at all in the limit where the regulator brane position goes to infinity. In the low energy limit, the massless four dimensional graviton obeys the usual 4d equation and is therefore also not generated in a radiation-dominated universe.Comment: 9 pages, minor changes, references correcte

NOA1, a Novel ClpXP Substrate, Takes an Unexpected Nuclear Detour Prior to Mitochondrial Import

The mitochondrial matrix GTPase NOA1 is a nuclear encoded protein, essential for mitochondrial protein synthesis, oxidative phosphorylation and ATP production. Here, we demonstrate that newly translated NOA1 protein is imported into the nucleus, where it localizes to the nucleolus and interacts with UBF1 before nuclear export and import into mitochondria. Mutation of the nuclear localization signal (NLS) prevented both nuclear and mitochondrial import while deletion of the N-terminal mitochondrial targeting sequence (MTS) or the C-terminal RNA binding domain of NOA1 impaired mitochondrial import. Absence of the MTS resulted in accumulation of NOA1 in the nucleus and increased caspase-dependent apoptosis. We also found that export of NOA1 from the nucleus requires a leptomycin-B sensitive, Crm1-dependent nuclear export signal (NES). Finally, we show that NOA1 is a new substrate of the mitochondrial matrix protease complex ClpXP. Our results uncovered an unexpected, mandatory detour of NOA1 through the nucleolus before uptake into mitochondria. We propose that nucleo-mitochondrial translocation of proteins is more widespread than previously anticipated providing additional means to control protein bioavailability as well as cellular communication between both compartments.Max Planck Society for the Advancement of Scienc

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss

The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells. BK channels have been shown to be composed of the pore-forming alpha-subunit coexpressed with the auxiliary beta-1-subunit. Analyzing the hearing function and cochlear phenotype of BK channel alpha-(BKalpha–/–) and beta-1-subunit (BKbeta-1–/–) knockout mice, we demonstrate normal hearing function and cochlear structure of BKbeta-1–/– mice. During the first 4 postnatal weeks also, BKalpha–/– mice most surprisingly did not show any obvious hearing deficits. High-frequency hearing loss developed in BKalpha–/– mice only from ca. 8 weeks postnatally onward and was accompanied by a lack of distortion product otoacoustic emissions, suggesting outer hair cell (OHC) dysfunction. Hearing loss was linked to a loss of the KCNQ4 potassium channel in membranes of OHCs in the basal and midbasal cochlear turn, preceding hair cell degeneration and leading to a similar phenotype as elicited by pharmacologic blockade of KCNQ4 channels. Although the actual link between BK gene deletion, loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations. © 2004, The National Academy of Sciences. Freely available online through the PNAS open access option

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