Strings on type IIB pp-wave backgrounds with interacting massive theories on the worldsheet

We consider superstring theories on pp-wave backgrounds which result in an integrable ${\cal N}=(2,2)$ supersymmetric Landau-Ginzburg theory on the worldsheet. We obtain exact eigenvalues of the light-cone gauge superstring hamiltonian in the massive and interacting world-sheet theory with superpotential $Z^3-Z$. We find the modes of the supergravity part of the string spectrum, and their space-time interpretation. Because the system is effectively at strong coupling on the worldsheet, these modes are not in one-to-one correspondence with the usual type IIB supergravity modes in the $p_{-} \to 0$ limit. However, the above correspondence holds in the $\alpha'\to 0$ limit.Comment: 20 pages, 1 figure; minor changes, comments adde

Mesophase Separation and Probe Dynamics in Protein-Polyelectrolyte Coacervates

Protein–polyelectrolyte coacervates are self-assembling macroscopically monophasic biomacromolecular fluids whose unique properties arise from transient heterogeneities. The structures of coacervates formed at different conditions of pH and ionic strength from poly(dimethyldiallylammonium chloride) and bovine serum albumin (BSA), were probed using fluorescence recovery after photobleaching. Measurements of self-diffusion in coacervates were carried out using fluorescein-tagged BSA, and similarly tagged Ficoll, a non-interacting branched polysaccharide with the same size as BSA. The results are best explained by temporal and spatial heterogeneities, also inferred from static light scattering and cryo-TEM, which indicate heterogeneous scattering centers of several hundred nm. Taken together with previous dynamic light scattering and rheology studies, the results are consistent with the presence of extensive dilute domains in which are embedded partially interconnected 50–700 nm dense domains. At short length scales, protein mobility is unobstructed by these clusters. At intermediate length scales, proteins are slowed down due to tortuosity effects within the blind alleys of the dense domains, and to adsorption at dense/dilute domain interfaces. Finally, at long length scales, obstructed diffusion is alleviated by the break-up of dense domains. These findings are discussed in terms of previously suggested models for protein–polyelectrolyte coacervates. Possible explanations for the origin of mesophase separation are offered

Cosmology as Geodesic Motion

For gravity coupled to N scalar fields with arbitrary potential V, it is shown that all flat (homogeneous and isotropic) cosmologies correspond to geodesics in an (N+1)-dimensional `augmented' target space of Lorentzian signature (1,N), timelike if V>0, null if V=0 and spacelike if V<0. Accelerating cosmologies correspond to timelike geodesics that lie within an `acceleration subcone' of the `lightcone'. Non-flat (k=-1,+1) cosmologies are shown to evolve as projections of geodesic motion in a space of dimension (N+2), of signature (1,N+1) for k=-1 and signature (2,N) for k=+1. This formalism is illustrated by cosmological solutions of models with an exponential potential, which are comprehensively analysed; the late-time behviour for other potentials of current interest is deduced by comparison.Comment: 26 pages, 2 figures, journal version with additional reference

Organophilic, Superparamagnetic, and Reversibly Thermoresponsive Silica-Polypeptide Core-Shell Particles

Particles with a superparamagnetic cobalt inner core, silica outer core, and covalently bound homopolypeptide shell were investigated under thermal and magnetic stimuli. The homopolypeptide was poly(ϵ-carbobenzyloxy-l-lysine), PCBL, which is known to exhibit a thermoreversible coil → helix transition when dissolved as a pure polymer in m-cresol. Tethering to a core particle did not prevent PCBL from undergoing this conformational transition, as confirmed by dynamic light scattering and optical rotation, but the transition was broadened compared to that of the untethered polymer. The Co@SiO2-PCBL hybrid particles retained the superparamagnetic properties of the cobalt inner nougat. Indeed, some response remains even after aging for \u3e5 years. The aged PCBL shell also preserved its responsiveness to temperature, although differences in the shape of the size vs temperature transition curve were observed compared to the freshly made particles. A reversible coil → helix transition for a particle-bound polypeptide in a pure organic solvent is rare. In addition to providing a convenient tool for characterizing coil → helix transitions for surface-bound polypeptides without interference from pH or the strong ionic forces that dominate behavior in aqueous systems, the Co@SiO2-PCBL/m-cresol system may prove useful in studies of the effect of shell polymer conformation on colloid interactions. The stability of the magnetic core and polypeptide shell suggest a long shelf life for Co@SiO2-PCBL, which can, in principle, be deprotected to yield positively charged Co@SiO2-poly(l-lysine) particles for possible transfection or antimicrobial applications or chained magnetically to produce responsive poly(colloids)

Impact of microRNAs in Resistance to Chemotherapy and Novel Targeted Agents in Non-Small Cell Lung Cancer

Despite recent advances in understanding the cancer signaling pathways and in developing new therapeutic strategies, non-small cell lung cancer (NSCLC) shows grim prognosis and high incidence of recurrence. Insufficient dis- ruption of oncogenic signaling and drug resistance are the most common causes of tumor recurrence. Drug resistance, in- trinsic or acquired, represents a main obstacle in NSCLC therapeutics by limiting the efficacy both of conventional che- motherapeutic compounds and new targeted agents. Therefore, novel and more innovative approaches are required for treatment of this tumor. MicroRNAs (miRNAs) are a family of small non-coding RNAs that regulate gene expression by sequence-specific targeting of mRNAs causing mRNA degradation or translational repression. Accumulating evidence suggests that impairment of candidate miRNAs may be involved in the acquisition of tumor cell resistance to conventional chemotherapy and novel biological agents by affecting the drug sensitivity of cancer cells. The modulation of these miR- NAs, using antagomiRs or miRNA mimics, can restore key gene networks and signaling pathways, and optimize anti- cancer therapies by inhibition of tumor cell proliferation and increasing the drug sensitivity. Therefore, miRNA-based therapeutics provides an attractive anti-tumor approach for developing new and more effective individualized therapeutic strategies, improving drug efficiency, and for predicting the response to different anticancer drugs. In this review, we pre- sent an overview on the role of miRNAs in resistance mechanisms of NSCLC, discussing the main studies on the aberra- tions in apoptosis, cell cycle and DNA damage repair pathways, as well as in novel drug targets

Quiet Eye Duration and Gun Motion in Elite Shotgun Shooting

INTRODUCTION: No literature exists to document skill-related differences in shotgun shooting and whether these may be a function of eye movements and control of gun motion. We therefore conducted an exploratory investigation of the visual search behaviors and gun barrel kinematics used by elite and subelite shooters across the three shotgun shooting subdisciplines. METHODS: Point of gaze and gun barrel kinematics were recorded in groups of elite (n = 24) and subelite (n = 24) shooters participating in skeet, trap, and double trap events. Point of gaze was calculated in relation to the scene, while motion of the gun was captured by two stationary external cameras. Quiet eye (final fixation or tracking gaze that is located on a specific location/object in the visual display for a minimum of 100 ms) duration and onset were analyzed as well as gun motion profiles in the horizontal and vertical planes. RESULTS: In skeet, trap, and double trap disciplines, elite shooters demonstrated both an earlier onset and a longer relative duration of quiet eye than their subelite counterparts did. Also, in all three disciplines, quiet eye duration was longer and onset earlier during successful compared with unsuccessful trials for elite and subelite shooters. Kinematic analyses indicated that a slower movement of the gun barrel was used by elite compared with subelite shooters. CONCLUSIONS: Overall, stable gun motion and a longer quiet eye duration seem critical to a successful performance in all three shotgun disciplines

Differences in cortical activity related to motor planning between experienced guitarists and non-musicians during guitar playing.

The influence of motor skill learning on movement-related brain activity was investigated using electroencephalography. Previous research has indicated that experienced performers display movement-related cortical potentials (MRCPs) of smaller amplitude and later onset compared to novices participants. Unfortunately, previous studies have lacked ecological validity with experimenters recording the MRCP prior to simple motor tasks and applying the results to more complex motor skills. This study replicated previous research using an ecologically valid motor skill; recording the MRCP from a group of experienced guitarists and a control group of non-musicians while they played a simple scale on the guitar. Results indicated no difference between groups in early motor planning. In contrast, the later, negative slope and motor potential components were of smaller amplitude and the negative slope began later in the experienced guitarists. The data may indicate that, for experienced guitarists, a reduced level of effort is required during the motor preparation phase of the task. These findings have implications for musical instrument learning as well as motor skill acquisition in general

Raman spectroscopy of a single ion coupled to a high-finesse cavity

We describe an ion-based cavity-QED system in which the internal dynamics of an atom is coupled to the modes of an optical cavity by vacuum-stimulated Raman transitions. We observe Raman spectra for different excitation polarizations and find quantitative agreement with theoretical simulations. Residual motion of the ion introduces motional sidebands in the Raman spectrum and leads to ion delocalization. The system offers prospects for cavity-assisted resolved-sideband ground-state cooling and coherent manipulation of ions and photons.Comment: 8 pages, 6 figure