Spanish Artifacts from Santa Elena

This volume contains Parts I and 2 of a three-part presentation of the artifacts relating to the sixteenth century Spanish occupation of the colonial capital of La Florida at Santa Elena, located on Parris Island, South Carolina from 1566 to 1587. Part 1, by Stanley South, with contributions by Eugene Lyon, Richard Polhemus, William Radisch and Carl Steen, comprises the Spanish non-ceramic artifacts. Part 2, by Russell Skowronek, Richard Johnson and Stanley South, examines the Spanish imported ceramics. Part 3, incomplete at this writing, by Chester Depratter, deals with the Spanish-contemporary Indian pottery. This third part will be published as a separate volume at a later date. The entire artifact inventory of the artifacts from Santa Elena is presented in this three-part volume, being those recovered from a number of expeditions to the site between 1979 and 1985. For comparative use the appendices contain the tabulated artifact inventory resulting from these expeditions. Synthesizing tables from these data are presented in the text. This information should prove useful to students of sixteenth century Spanish colonial history, particularly historical archaeologists involved in excavating sites of this period wherever they may be.https://scholarcommons.sc.edu/archanth_anthro_studies/1008/thumbnail.jp

Metformin as a Therapeutic Target in Endometrial Cancers.

Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer

Uncivil behaviour in the workplace causes mental fatigue and is contagious

Employees on the receiving end tend to ‘pay forward’ the incivility to others, write Christopher C. Rosen, Joel Koopman, Allison S. Gabriel and Russell E. Johnso

The Ursinus Weekly, November 7, 1932

Max Montor featured in dramatic offerings • Bears claw undefeated Drexel Dragons in humiliating defeat, 28-6 • Girls\u27 hockey team loses to Swarthmore sticksters • Frosh tie Dragons, 6-6 after close fight • Ursinus debating league to convene this Saturday • Zimmer Harp Trio will be heard in recital • Track men to compete in conference meet • Social activities council discusses future plans • Novel hobo hop presents Ken Nichols and his orchestra • Men\u27s student council discuss conference plans • Schaff play cast picked • Tea served at Shreiner • Faculty club meets at Dr. Barnard\u27s • Co-eds feature Halloween party in field cage • Results of YWCA ballot point to Hoover\u27s election • Varsity Club convenes • Glee Club scheduled for two concerts this week • WSGA convenes • Mod. lang. group meets • Y.W. discusses politics • Y.W.C.A. cabinet meeting • Inter-sorority council discusses rushing rules • Booters defeat Haverford 3rd by decisive 2-0 count • Y.M.-Y.W.C.A. to present Ba thane, play of India • Sunday school groups hold interesting discussions • Assistants for 1934 Ruby • Drexel pep meetinghttps://digitalcommons.ursinus.edu/weekly/2035/thumbnail.jp

Public Perception of Engineering Technology: A Literature Review

Engineering technology describes a field closely related to engineering in which practical application of learned concepts is emphasized over theoretical knowledge. Although an increasing amount of emphasis is being placed on the importance of this experiential learning in all engineering curricula, and the specifics of engineering technology’s place among engineering and technical fields is becoming clearer, there are still significant gaps in our understanding of several key aspects of this field. One of these aspects is its perception by the general public, which is important in, among other things, determining the employability of engineering technology program graduates and encouraging the development of engineering technology curricula. Currently, existing literature on the subject is sparse, especially compared to the number and extent of similar studies done in related fields; the studies that are performed on the topic are generally restricted to a very specific demographic, and are not easily applicable to the entire population of engineering technology students and professionals. However, what information does exist suggests that this lack of research impedes the professional growth of those who are involved in engineering technology, including restricting the ability of faculty to recruit students interested in engineering technology programs, decreasing the effectiveness of guidance available to those students through advisors and outside programs, and preventing inequities currently present in the engineering field as a whole from being addressed. By acknowledging the gaps in current knowledge, direction for future research may be provided; thus, this review seeks to outline what research already exists on the public perception of engineering technology, and thereby highlight specific areas in which our understanding of this perception is particularly poor

Lessons Learned from the Flight Unit Testing of the Near Earth Asteroid Scout Flight System

The Near Earth Asteroid Scout flight mission is set to launch on the maiden voyage of the Space Launch System as a secondary payload. The spacecraft will be jettisoned in cis-lunar space and embark on an ambitious 2.5 year mission to image an asteroid. The spacecraft is uniquely equipped with an 85m2 solar sail as the main propulsion system. The monolithic sail system is designed to package within a 6U volume for launch and then deploy during flight. The NEA Scout team has presented in the past to the International Symposium on Solar Sailing topics related to the engineering development unit and design efforts to achieve flight hardware build. This paper will focus on the lessons learned from building and testing the NEA Scout flight system. Focus will be on the mechanical, software, and electrical interfaces as well as preparation for subsystem environmental tests, including thermal vacuum. Due to the unique design of the spacecraft, the solar sail subsystem was required to be located in the center of the spacecraft. This requirement lead to design challenges such as designing and accommodating critical cable harnesses to run through the center of the sail subsystem, packaging and deployment design of the sail subsystem, and integrated testing efforts through an avionics test bed to verify and validate a complete system architecture

Radial artery access site complications during cardiac procedures, clinical implications and potential solutions : the role of nitric oxide

Supported by the European Social Fund and Scottish Funding Council as part of Developing Scotland’s Workforce in the Scotland 2014-2020 European Structural and Investment Fund Programme.Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery, as this is safer than the femoral approach. However, despite improvements in technology and techniques, complications can occur. The most common complication, arterial spasm, can cause intense pain and, in some cases, procedural failure. The incidence of spasm is dependent on several variables, including operator experience, artery size, and equipment used. An anti-spasmolytic cocktail can be applied to reduce spasm, which usually includes an exogenous nitric oxide (NO) donor (glyceryl trinitrate). NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention. However, systemic administration can result in unwanted side-effects, such as hypotension. A method that adopts local delivery of NO might be advantageous. This review article describes the mechanisms involved in radial artery spasm, discusses the advantages and disadvantages of current strategies to reduce spasm, and highlight the potential of NO-loaded nanoporous materials for use in this setting.Publisher PDFPeer reviewe

Field repair and replacement part fabrication of military components using ultrasonic consolidation cold metal deposition

Timely repair and replacement of military components without degrading material properties offers tremendous opportunities for cost and schedule savings on a number of military platforms. Effective field-based additive manufacturing repair approaches have proven difficult to develop, as conventional additive metal deposition technologies typically include a molten phase transformation and controlled inert deposition environments. The molten stage of laser and electron beam based additive processes unfortunately results in large dimensional and microstructural changes to the component being repaired or re-fabricated. As a result, high residual stresses and unpredictable ductility profiles in the repair area, or the re-fabricated part, make the final product unsafe for redeployment. Specifically, the heat affected zone associated with traditional deposition-based repair methods can produce a low strength, non-homogenous region at the joint; these changes in the materials properties of the repaired parts are detrimental to the fatigue life, and are a major concern where cyclic loading is experienced. The use of solid state high power Ultrasonic Consolidation (UC) technologies avoids the liquid-solid transition complexity and creates a predictable “cold” bond. This method then allows for strong, homogenous structures to be manufactured and repaired in the field and opens the door for the use of high strength repair material that may reduce the frequency of future failure itself. In addition, UC further offers the opportunity to provide enhanced functionality and ruggedness to a component either during repair or from original manufacture by allowing the embedding of passive and functional elements into the new fabricated component or feature

Improving the triple bottom line returns from smallholder tree farms in the Philippines: A systems approach

This paper outlines the application of systems thinking in investigating ways to improve the returns to smallholder tree farmers in the Philippines. The paper illustrates how a systems approach was used in the conceptualisation of the project and how systems thinking facilitated a shared understanding of the how each individual’s research contributed to the broader project activities. Systems thinking has also been used in the design and implementation of various project activities. Three examples are provided. The first example illustrates how a systems diagram was developed which outlined the direct and indirect linkages between biophysical data on tree farms and various activities designed to increase returns. The second example illustrates how the suggested approach for improving the flow of information concerning tree registration, harvest and transportation regulations and approval mechanisms link with various project activities and have been informed by a series of action research workshops. The third example illustrates how systems thinking has been applied to understand the factors affecting the production of high quality tree seedlings and to investigate the effect of policy interventions on improving the quality of seedlings available to smallholders

Approach or avoidance (or both?): Integrating core self-evaluations within an approach/avoidance framework

Core self-evaluations (CSE) represent a new personality construct that,despite an accumulation of evidence regarding its predictive validity,provokes debate regarding the fundamental approach or avoidance na-ture of the construct. This set of studies sought to clarify the ap-proach/avoidance nature of CSE by examining its relation with ap-proach/avoidance personality traits and motivation constructs (Study 1);we subsequently examined approach/avoidance motivational mecha-nisms as mediators of the relation between CSE and job performance(Study 2). Overall, the studies demonstrate that CSE is best concep-tualized as representing both (high) approach tendencies and (low)avoidance tendencies; implications of these findings for CSE theoryare discussed