643 research outputs found
Alien Registration- Russell, Angus (Fort Fairfield, Aroostook County)
https://digitalmaine.com/alien_docs/25050/thumbnail.jp
Alien Registration- Russell, Angus F. (Presque Isle, Aroostook County)
https://digitalmaine.com/alien_docs/33452/thumbnail.jp
Birds of the Navajo Country
journal articleThe Navajo country as covered in this paper lies in southeastern Utah and northeastern Arizona and is bounded on the north, west and south by the San Juan, Colorado, Little Colorado and Rio Puerco rivers and on the east by the Arizona-New Mexico state line. That part of the Navajo country lying in northwestern New Mexico, while not covered in this paper, is ecologically similar and is probably but little different faunistically
Gate-based spin readout of hole quantum dots with site-dependent factors
The rapid progress of hole spin qubits in group IV semiconductors has been
driven by their potential for scalability. This is owed to the compatibility
with industrial manufacturing standards, as well as the ease of operation and
addressability via all-electric drives. However, owing to a strong spin-orbit
interaction, these systems present variability and anisotropy in key qubit
control parameters such as the Land\'e factor, requiring careful
characterisation for reliable qubit operation. Here, we experimentally
investigate a hole double quantum dot in silicon by carrying out spin readout
with gate-based reflectometry. We show that characteristic features in the
reflected phase signal arising from magneto-spectroscopy convey information on
site-dependent factors in the two dots. Using analytical modeling, we
extract the physical parameters of our system and, through numerical
calculations, we extend the results to point out the prospect of conveniently
extracting information about the local factors from reflectometry
measurements.Comment: Main manuscript: 12 pages, 8 figures. Supplementary Information: 3
pages, 2 figure
Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach.
One Health surveillance involves the analysis of human, animal and environmental samples, recognising their interconnectedness in health systems. Such considerations are crucial to investigate the transmission of many pathogens, including drug-resistant bacteria and parasites. The highest rates of antimicrobial resistance (AMR)-associated deaths are observed in sub-Saharan Africa, where concurrently the waterborne parasitic disease schistosomiasis can be highly endemic in both humans and animals. Although there is growing acknowledgment of significant interactions between bacteria and parasites, knowledge of relationships between schistosomes, microbes and AMR remains inadequate. In addition, newly emergent research has revealed the previously underappreciated roles of animals and the environment in both AMR and schistosomiasis transmission. We consider shared environmental drivers and colonisation linkage in this narrative review, with a focus on extended-spectrum beta-lactamase-mediated resistance among bacteria from the Enterobacteriaceae family, which is exceedingly prevalent and responsible for a high burden of AMR-associated deaths. Then we examine novel findings from Malawi, where the landscapes of AMR and schistosomiasis are rapidly evolving, and make comparisons to other geographic areas with similar co-infection epidemiology. We identify several knowledge gaps that could be addressed in future research, including the need to characterise the impact of intestinal schistosomiasis and freshwater contact on intestinal AMR colonisation, before proposing a rationale for connecting AMR surveillance and schistosomiasis research within a One Health framework
Narrative change in psychotherapy: differences between good and bad outcome cases in cognitive, narrative, and prescriptive therapies
This study aimed to clarify the relationship between changes in the
patients’ narratives and therapeutic outcomes. Two patients were
selected from three psychotherapeutic models (cognitive, narrative,
and prescriptive therapies), one with good therapeutic outcome and
the other with bad therapeutic outcome. Sessions from the initial,
middle, and final phases for each patient were evaluated in terms of
narrative structural coherence, process complexity, and content
diversity. Differences between patients’ total narrative production
were found at the end of the therapeutic process. Good outcome
cases presented a higher statistically significant total narrative change
than poor outcome case
Vasopressin in conjunction with norepinephrine in septic shock: A retrospective cohort study from a low middle-income country
Objectives: Guidelines recommend use of norepinephrine as the first-line treatment for fluid-refractory septic shock and if septic shock persists vasopressin may be initiated. Since there are limited data from low middle-income countries with high disease burden of sepsis, we aimed to compare the outcomes of using vasopressin adjunct to norepinephrine in comparison with norepinephrine alone.Design: Retrospective cohort study.Setting: Aga Khan University Hospital, Karachi, Pakistan.Patients: Six-hundred fifty-three patients diagnosed with septic shock from January 2019 to December 2019, with 498 given norepinephrine only and 155 given norepinephrine-vasopressin combination.Interventions: None.Measurements and main results: Primary outcome was in-hospital mortality. Secondary outcomes were duration of vasopressor used, length of hospital stay, length of ICU stay, and days on ventilatory support. After adjustment by multivariable logistic regression, it was found that mortality was not significantly associated with the norepinephrine-vasopressin combination (adjusted odds ratio, 0.633 [95% CI, 0.370-1.081]). However, Sequential Organ Failure Assessment score at admission (1.100 [1.014-1.193]), lactate at admission (1.167 [1.109-1.227]), duration of vasopressor used (1.481 [1.316-1.666]), and level of care (3.025 [1.682-5.441]) were found to be independently associated with the adjunct usage of norepinephrine and vasopressin.Conclusions: The use of norepinephrine-vasopressin combination has remained debatable in literature. Our study showed that although there was no difference in mortality between the two groups, admission Sequential Organ Failure Assessment scores and admission lactate levels were found to be significantly higher in the norepinephrine-vasopressin group. Hence, physicians from Pakistan used the norepinephrine-vasopressin combination in resistant septic shock patients who were sicker to begin with. Furthermore, duration of vasopressor therapy and ICU admission were also significantly higher in the combination group. Considering the recent hyperinflation of vasopressors costs and that most healthcare expenditure for patients in Pakistan is out-of-pocket, this can consequently lead to unwarranted financial burden for patients and their families
HALT (Hernia Active Living Trial):protocol for a feasibility study of a randomised controlled trial of a physical activity intervention to improve quality of life in people with bowel stoma with a bulge/parastomal hernia
Background: Parastomal hernia (PSH) can be repaired surgically, but results to date have been disappointing, with reported recurrence rates of 30 to 76%. Other types of intervention are therefore needed to improve the quality of life of people with PSH. One potential intervention is physical activity. We hypothesise that the intervention will increase core activation and control across the abdominal wall at a site of potential weakness and thus reduce the risk of PSH progression. Increases in physical activity will improve body image and quality of life (QoL). Methods: Subjects and sample There were approximately 20 adults with a bowel stoma and PSH. People with previous PSH repair will be excluded as well as people who already do core training. Study design This is a feasibility study of a randomised controlled trial with 2 months follow-up, in 2 sites using mixed methods. Stage 1 involves intervention development and in stage 2, intervention and trial parameters will be assessed. Intervention A theoretically informed physical activity intervention was done, targeting people with PSH. Main outcome of feasibility study The main outcome is the decision by an independent Study Steering Committee whether to proceed to a full randomised controlled trial of the intervention. Other outcomes We will evaluate 4 intervention parameters—fidelity, adherence, acceptability and safety and 3 trial parameters (eligible patients’ consent rate, acceptability of study design and data availability rates for following endpoints): I. Diagnosis and classification of PSHII. Muscle activation III. Body composition (BMI, waist circumference) IV. Patient reported outcomes: QoL, body image and physical functioning V. Physical activity; VI. Psychological determinants of physical activity Other data Included are other data such as interviews with all participants about the intervention and trial procedures. Data analysis and statistical power As this is a feasibility study, the quantitative data will be analysed using descriptive statistics. Audio-recorded qualitative data from interviews will be transcribed verbatim and analysed thematically. Discussion: The feasibility and acceptability of key intervention and trial parameters will be used to decide whether to proceed to a full trial of the intervention, which aims to improve body image, quality of life and PSH progression.</p
Demonstration of a switchable damping system to allow low-noise operation of high-Q low-mass suspension systems
Low mass suspension systems with high-Q pendulum stages are used to enable
quantum radiation pressure noise limited experiments. Utilising multiple
pendulum stages with vertical blade springs and materials with high quality
factors provides attenuation of seismic and thermal noise, however damping of
these high-Q pendulum systems in multiple degrees of freedom is essential for
practical implementation. Viscous damping such as eddy-current damping can be
employed but introduces displacement noise from force noise due to thermal
fluctuations in the damping system. In this paper we demonstrate a passive
damping system with adjustable damping strength as a solution for this problem
that can be used for low mass suspension systems without adding additional
displacement noise in science mode. We show a reduction of the damping factor
by a factor of 8 on a test suspension and provide a general optimisation for
this system.Comment: 5 pages, 5 figure
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