5,997 research outputs found
Level statistics and eigenfunctions of pseudointegrable systems: dependence on energy and genus number
We study the level statistics (second half moment and rigidity
) and the eigenfunctions of pseudointegrable systems with rough
boundaries of different genus numbers . We find that the levels form energy
intervals with a characteristic behavior of the level statistics and the
eigenfunctions in each interval. At low enough energies, the boundary roughness
is not resolved and accordingly, the eigenfunctions are quite regular functions
and the level statistics shows Poisson-like behavior. At higher energies, the
level statistics of most systems moves from Poisson-like towards Wigner-like
behavior with increasing . Investigating the wavefunctions, we find many
chaotic functions that can be described as a random superposition of regular
wavefunctions. The amplitude distribution of these chaotic functions
was found to be Gaussian with the typical value of the localization volume
. For systems with periodic boundaries we find
several additional energy regimes, where is relatively close to the
Poisson-limit. In these regimes, the eigenfunctions are either regular or
localized functions, where is close to the distribution of a sine or
cosine function in the first case and strongly peaked in the second case. Also
an interesting intermediate case between chaotic and localized eigenfunctions
appears
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Medication decision-making for patients with renal insufficiency in inpatient and outpatient care at a US Veterans Affairs Medical Centre: a qualitative, cognitive task analysis.
BackgroundMany studies identify factors that contribute to renal prescribing errors, but few examine how healthcare professionals (HCPs) detect and recover from an error or potential patient safety concern. Knowledge of this information could inform advanced error detection systems and decision support tools that help prevent prescribing errors.ObjectiveTo examine the cognitive strategies that HCPs used to recognise and manage medication-related problems for patients with renal insufficiency.DesignHCPs submitted documentation about medication-related incidents. We then conducted cognitive task analysis interviews. Qualitative data were analysed inductively.SettingInpatient and outpatient facilities at a major US Veterans Affairs Medical Centre.ParticipantsPhysicians, nurses and pharmacists who took action to prevent or resolve a renal-drug problem in patients with renal insufficiency.OutcomesEmergent themes from interviews, as related to recognition of renal-drug problems and decision-making processes.ResultsWe interviewed 20 HCPs. Results yielded a descriptive model of the decision-making process, comprised of three main stages: detect, gather information and act. These stages often followed a cyclical path due largely to the gradual decline of patients' renal function. Most HCPs relied on being vigilant to detect patients' renal-drug problems rather than relying on systems to detect unanticipated cues. At each stage, HCPs relied on different cognitive cues depending on medication type: for renally eliminated medications, HCPs focused on gathering renal dosing guidelines, while for nephrotoxic medications, HCPs investigated the need for particular medication therapy, and if warranted, safer alternatives.ConclusionsOur model is useful for trainees so they can gain familiarity with managing renal-drug problems. Based on findings, improvements are warranted for three aspects of healthcare systems: (1) supporting the cyclical nature of renal-drug problem management via longitudinal tracking mechanisms, (2) providing tools to alleviate HCPs' heavy reliance on vigilance and (3) supporting HCPs' different decision-making needs for renally eliminated versus nephrotoxic medications
Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study
BACKGROUND: Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipient phase of dementia ascribed to diminished self-care, including sub-optimal nutrition, would have the effect of generating such an inverse association. One approach to circumventing this problem would be to measure weight in a population which is young enough to be free of the symptoms of dementia which is then followed up for dementia occurrence over many decades. METHODS: In a prospective cohort study, body mass index, and other potential risk factors, were measured in 9547 male university undergraduates (mean age 20.5Â years) in 1948-68 who were then linked to national mortality registers. RESULTS: Of 2537 deaths over a mean of 50.6Â years follow up, 140 were ascribed to dementia. There was no association between overweight and future dementia deaths (age-adjusted hazard ratio; 95Â % confidence interval: 0.93; 0.49, 1.79). CONCLUSION: In this cohort study of former university students, being overweight in youth did not confer protection against later dementia death
Antichain cutsets of strongly connected posets
Rival and Zaguia showed that the antichain cutsets of a finite Boolean
lattice are exactly the level sets. We show that a similar characterization of
antichain cutsets holds for any strongly connected poset of locally finite
height. As a corollary, we get such a characterization for semimodular
lattices, supersolvable lattices, Bruhat orders, locally shellable lattices,
and many more. We also consider a generalization to strongly connected
hypergraphs having finite edges.Comment: 12 pages; v2 contains minor fixes for publicatio
Statistical Searches for Microlensing Events in Large, Non-Uniformly Sampled Time-Domain Surveys: A Test Using Palomar Transient Factory Data
Many photometric time-domain surveys are driven by specific goals, such as
searches for supernovae or transiting exoplanets, which set the cadence with
which fields are re-imaged. In the case of the Palomar Transient Factory (PTF),
several sub-surveys are conducted in parallel, leading to non-uniform sampling
over its footprint. While the median PTF field has been imaged 40 times in \textit{R}-band,
have been observed 100 times. We use PTF data to
study the trade-off between searching for microlensing events in a survey whose
footprint is much larger than that of typical microlensing searches, but with
far-from-optimal time sampling. To examine the probability that microlensing
events can be recovered in these data, we test statistics used on uniformly
sampled data to identify variables and transients. We find that the von Neumann
ratio performs best for identifying simulated microlensing events in our data.
We develop a selection method using this statistic and apply it to data from
fields with 10 -band observations, light curves,
uncovering three candidate microlensing events. We lack simultaneous,
multi-color photometry to confirm these as microlensing events. However, their
number is consistent with predictions for the event rate in the PTF footprint
over the survey's three years of operations, as estimated from near-field
microlensing models. This work can help constrain all-sky event rate
predictions and tests microlensing signal recovery in large data sets, which
will be useful to future time-domain surveys, such as that planned with the
Large Synoptic Survey Telescope.Comment: 13 pages, 14 figures; accepted for publication in ApJ. fixed author
lis
Perturbations of a Universe Filled with Dust and Radiation
A first-order perturbation approach to Friedmann cosmologies filled
with dust and radiation is developed. Adopting the coordinate gauge comoving
with the perturbed matter, and neglecting the vorticity of the radiation, a
pair of coupled equations is obtained for the trace of the metric
perturbations and for the velocity potential . A power series solution with
upwards cutoff exists such that the leading terms for large values of the
dimensionless time agree with the relatively growing terms of the dust
solution of Sachs and Wolfe.Comment: 9 pp, typeset in late
Pretransplant HLA typing revealed loss of heterozygosity in the major histocompatibility complex in a patient with acute myeloid leukemia
Introduction
Chromosomal abnormalities are frequent events in hematological malignancies. The degree of HLA compatibility between donor and recipient in hematopoietic stem cell transplantation is critical.
Purpose of the study
In this report, we describe an acute myeloid leukemia case with loss of heterozygosity (LOH) encompassing the entire HLA.
Materials and methods
HLA molecular typing was performed on peripheral blood (PB) and buccal swabs (BS). Chromosomal microarray analysis (CMA) was performed using a whole genome platform.
Results
Typing results on PB sample collected during blast crisis demonstrated homozygosity at the -A, -B, -C, -DR, and -DQ loci. A BS sample demonstrated heterozygosity at all loci. A subsequent PB sample drawn after count recovery confirmed heterozygosity. The CMA performed on PB samples collected during and after blast crisis revealed a large terminal region of copy-neutral LOH involving chromosome region 6p25.3p21.31, spanning approximately 35.9 Mb. The results of the CMA assay on sample collected after count recovery did not demonstrate LOH.
Conclusions
LOH at the HLA gene locus may significantly influence the donor search resulting in mistakenly choosing homozygous donors. We recommend confirming the HLA typing of recipients with hematological malignancies when homozygosity is detected at any locus by using BS samples, or alternatively from PB when remission is achieved
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In-situ resonant band engineering of solution-processed semiconductors generates high performance n-type thermoelectric nano-inks.
Thermoelectric devices possess enormous potential to reshape the global energy landscape by converting waste heat into electricity, yet their commercial implementation has been limited by their high cost to output power ratio. No single "champion" thermoelectric material exists due to a broad range of material-dependent thermal and electrical property optimization challenges. While the advent of nanostructuring provided a general design paradigm for reducing material thermal conductivities, there exists no analogous strategy for homogeneous, precise doping of materials. Here, we demonstrate a nanoscale interface-engineering approach that harnesses the large chemically accessible surface areas of nanomaterials to yield massive, finely-controlled, and stable changes in the Seebeck coefficient, switching a poor nonconventional p-type thermoelectric material, tellurium, into a robust n-type material exhibiting stable properties over months of testing. These remodeled, n-type nanowires display extremely high power factors (~500 µW m-1K-2) that are orders of magnitude higher than their bulk p-type counterparts
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