Razão, religião e revolução: luzes e sombras nas telas de Jacques-Louis David

O artigo analisa a produção pictórica de Jacques-Louis David entre o final da década de 1770 e 1793, destacando o entrelaçamento entre arte, religião e política nas obras do artista francês. Em sua luta contra o Antigo Regime, “filósofos artistas”, como Jacques-Louis David, apossaram-se das armas que eram manipuladas, há séculos, por um de seus principais inimigos: a Igreja. A transmissão do ideário iluminista não poderia ficar restrita à “aridez” dos textos acadêmicos, devendo buscar na religião e nas artes o “encantamento” indispensável à conquista de olhos, ouvidos, cérebros e corações. Depois de recorrer aos heróis das antigas Grécia e Roma, Jacques-Louis David debruçou-se sobre os homens do seu tempo: os deputados de O juramento do jogo de pela e os mártires que sacrificaram suas vidas em prol da revolução. Entrelaçando a arte clássica com a cristã, razão, revolução e religião, Jacques-Louis David forjou estratégias que seriam mobilizadas na propagação de líderes e ideários políticos nos séculos XIX e XX.The article analyzes the pictorial production of Jacques-Louis David between the late 1770s and 1793, highlighting the links between art, religion and politics in the works of the French artist. In their struggle against the Old Regime “philosophers artists,” as Jacques-Louis David, they took possession of the weapons that were manipulated for centuries by one of its main enemies: the Church. The transmission of Enlightenment ideas could not be restricted to “aridity” of academic papers and should seek in religion and the arts the “enchantment” indispensable to the conquest of eyes, ears, brains and hearts. After resorting to the heroes of ancient Greece and Rome, Jacques-Louis David leaned across the men of his time: the deputies of Tennis Court Oath and the martyrs who sacrificed their lives for the sake of revolution. Interweaving classical art with Christian art, reason, revolution and religion, Jacques-Louis David forged strategies that would be mobilized in the spread of political leaders and ideologies in the nineteenth and twentieth centuries

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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