A technological organization analysis of Paleoamerican occupation, adaptation, and settlement at the Potter Site in the White Mountains of New Hampshire

In the New England Maritimes region, and especially New Hampshire, small lithic sites or scatters represent the most prevalent Paleoamerican site type identified on the landscape in the course of cultural resource management (CRM) and research activities. Correspondingly, distributed across this same landscape are a considerably far fewer number of significant large sites. Several different functional interpretations have been ascribed to these larger sites; all based on some version of the assumption that the large sites are accumulations of individual small sites either by aggregation or sequential visits. On present-day route 2 in the Moose River valley of the state of New Hampshire, a Paleoamerican site is situated with an area of 2 ½ acres, 11 excavation units (1m x 1m or greater) and containing approximately 15,900 lithic artifacts, that is known as the Potter site. This attribute depiction suggests similarities between Potter and the few other large regional sites broadly associated with the Vail/Debert and Gainey/Bull Brook time horizons or more specifically; Bull Brook, Whipple, Nobles Pond, Debert, Dedic/Sugarloaf, and Vail. These regional sites manifest in terms of the significant number of “hotspots” or loci, the rarity of its large size, earliest fluted point styles, low number of lithic material sources, rich artifact assemblages, site positioning overlooking a remnant of a glacial pond, and a chokepoint topography. The research question addressed in this doctoral thesis is: was Potter a single large seasonal hunting aggregation, single occupation marshaling event, seasonal episodic reuse interpretation or alternatively, a seasonal social aggregation site type, or perhaps something altogether different? The goal of this study was to evaluate the Potter site’s inhabitant’s lifeways, using flaked stone tool analysis modeling, in contrast to the rare number of large sites types identified regionally and to determine a response to the question; what kind of a site was Potter? Also, while in doing so, increasing the current understanding of the range of Paleoamerican horizon adaptations in the White Mountains of New Hampshire. Quantitative and qualitative, or more specifically formal and informal heuristic lithic analysis methods, were applied to the excavated site flake stone tool and debitage artifact assemblage to determine a response to the research questions. Each site locus was individually evaluated to infer behavior traits that comprise the site’s overall activities and settlement patterns yielding the interpretation of Potter as a seasonal episodic reuse site

Linking cause assessment, corporate philanthropy, and corporate reputation

This study analyzes the link between cause assessment, corporate philanthropy, and dimensions of corporate reputation from different stakeholders' perspectives, using balance theory as a conceptual framework and the telecommunications industry in Austria and Egypt as the empirical setting. Findings show that corporate philanthropy can improve perceptions of the corporate reputation dimensions, but the results vary between customers and non-customers and depend on the country setting

Effectiveness of ready-to-use therapeutic food compared to a corn/soy-blend-based pre-mix for the treatment of childhood moderate acute malnutrition in Niger.

Standard nutritional treatment of moderate acute malnutrition (MAM) relies on fortified blended flours though their importance to treat this condition is a matter of discussion. With the newly introduced World Health Organization growth standards, more children at an early stage of malnutrition will be treated following the dietary protocols as for severe acute malnutrition, including ready-to-use therapeutic food (RUTF). We compared the effectiveness of RUTF and a corn/soy-blend (CSB)-based pre-mix for the treatment of MAM in the supplementary feeding programmes (SFPs) supported by Médecins Sans Frontières, located in the Zinder region (south of Niger). Children measuring 65 to <110 cm, newly admitted with MAM [weight-for-height (WHM%) between 70% and <80% of the NCHS median] were randomly allocated to receive either RUTF (Plumpy'Nut®, 1000 kcal day(-1)) or a CSB pre-mix (1231 kcal day(-1)). Other interventions were similar in both groups (e.g. weekly family ration and ration at discharge). Children were followed weekly up to recovery (WHM% ≥ 85% for 2 consecutive weeks). In total, 215 children were recruited in the RUTF group and 236 children in the CSB pre-mix group with an overall recovery rate of 79.1 and 64.4%, respectively (p < 0.001). There was no evidence for a difference between death, defaulter and non-responder rates. More transfers to the inpatient Therapeutic Feeding Centre (I-TFC) were observed in the CSB pre-mix group (19.1%) compared to the RUTF group (9.3%) (p = 0.003). The average weight gain up to discharge was 1.08 g kg(-1) day(-1) higher in the RUTF group [95% confidence interval: 0.46-1.70] and the length of stay was 2 weeks shorter in the RUTF group (p < 0.001). For the treatment of childhood MAM in Niger, RUTF resulted in a higher weight gain, a higher recovery rate, a shorter length of stay and a lower transfer rate to the I-TFC compared to a CSB pre-mix. This might have important implications on the efficacy and the quality of SFPs

A unique role for 6-O sulfation modification in zebrafish vascular development

AbstractHeparan sulfate proteoglycans are important modulators of growth factor signaling in a variety of patterning processes. Secreted growth factors that play critical roles in angiogenesis bind to heparan sulfate, and this association is affected by 6-O-sulfation of the heparan sulfate chains. Addition of 6-O-sulfate is catalyzed by a family of sulfotransferases (HS6STs), and genetic manipulation of their function permits an assessment of their contribution to vascular assembly. We report on the biochemical activity and expression patterns of two zebrafish HS6ST genes. In situ hybridization reveals dynamic and distinct expression patterns of these two genes during development. Structural analysis of heparan sulfate from wild-type and morpholino antisense ‘knockdown’ embryos suggests that HS6ST-1 and HS6ST-2 have similar biochemical activity. HS6ST-2, but not HS6ST-1, morphants exhibit abnormalities in the branching morphogenesis of the caudal vein during embryonic development of the zebrafish. Our finding that HS6ST-2 is required for the branching morphogenesis of the caudal vein is the first in vivo evidence for an essential role of a gene encoding a heparan sulfate modifying enzyme in vertebrate angiogenesis. Our analysis of two zebrafish HS6ST genes suggests that a wide range of biological processes may be regulated by an array of sulfation-modifying enzymes in the vertebrate genome

Quadrupole collective modes in trapped finite-temperature Bose-Einstein condensates

Finite temperature simulations are used to study quadrupole excitations of a trapped Bose-Einstein condensate. We focus specifically on the m=0 mode, where a long-standing theoretical problem has been to account for an anomalous variation of the mode frequency with temperature. We explain this behavior in terms of the excitation of two separate modes, corresponding to coupled motion of the condensate and thermal cloud. The relative amplitudes of the modes depends sensitively on the temperature and on the frequency of the harmonic drive used to excite them. Good agreement with experiment is found for appropriate drive frequencies.Comment: 4 pages, 3 figure

Structural Test and Analysis of a Hybrid Inflatable Antenna

NASA is developing ultra-lightweight structures technology for communication antennas for space missions. One of the research goals is to evaluate the structural characteristics of inflatable and rigidizable antennas through test and analysis. Being able to test and analyze the structural characteristics of a full scale antenna is important to enable the simulation of various mission scenarios to determine system performance in space. Recent work completed to evaluate a Hybrid Inflatable Antenna concept will be discussed. Tests were completed on a 2-m prototype to optimize its static shape and identify its modal dynamics that are important for analytical model validation. These test results were used to evaluate a preliminary finite element model of the antenna, and this model development and correlation activity is also described in the paper

Design of Electromagnetic Cloaks and Concentrators Using Form-Invariant Coordinate Transformations of Maxwell's Equations

The technique of applying form-invariant, spatial coordinate transformations of Maxwell's equations can facilitate the design of structures with unique electromagnetic or optical functionality. Here, we illustrate the transformation-optical approach in the designs of a square electromagnetic cloak and an omni-directional electromagnetic field concentrator. The transformation equations are described and the functionality of the devices is numerically confirmed by two-dimensional finite element simulations. The two devices presented demonstrate that the transformation optic approach leads to the specification of complex, anisotropic and inhomogeneous materials with well directed and distinct electromagnetic behavior.Comment: submitted to "Photonics and Nanostructures", Special Issue "PECS VII", Elsevie

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer. This showed non-random patterns of copy number alterations significantly linked to EGFR and KRAS mutation status and to distinct clinical outcomes, and led to the discovery of a striking association of EGFR mutations with underexpression of DUSP4, a gene within a broad region of frequent single-copy loss on 8p. DUSP4 is involved in negative feedback control of EGFR signaling, and we provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. DUSP4 loss also associates with p16/CDKN2A deletion and defines a distinct clinical subset of lung cancer patients. Another novel observation is that of a reciprocal relationship between EGFR and LKB1 mutations. These results highlight the power of integrated genomics to identify candidate driver genes within recurrent broad regions of copy number alteration and to delineate distinct oncogenetic pathways in genetically complex common epithelial cancers