A study of the absorption coefficient of silicon in the wave length region between .5 and 1.1 microns Final report

Solar cell performance prediction from absorption coefficients of silicon in wavelengths from 0.5 to 1 micron as functions of doping levels and crystal damag

F-111 natural laminar flow glove flight test data analysis and boundary layer stability analysis

An analysis of 34 selected flight test data cases from a NASA flight program incorporating a natural laminar flow airfoil into partial wing gloves on the F-111 TACT airplane is given. This analysis determined the measured location of transition from laminar to turbulent flow. The report also contains the results of a boundary layer stability analysis of 25 of the selected cases in which the crossflow (C-F) and Tollmien-Schlichting (T-S) disturbance amplification factors are correlated with the measured transition location. The chord Reynolds numbers for these cases ranges from about 23 million to 29 million, the Mach numbers ranged from 0.80 to 0.85, and the glove leading-edge sweep angles ranged from 9 deg to 25 deg. Results indicate that the maximum extent of laminar flow varies from 56% chord to 9-deg sweep on the upper surface, and from 51% chord at 16-deg sweep to 6% chord at 25-deg sweep on the lower. The results of the boundary layer stability analysis indicate that when both C-F and T-S disturbances are amplified, an interaction takes place which reduces the maximum amplification factor of either type of disturbance that can be tolerated without causing transition

Novel ocular antihypertensive compounds in clinical trials

June Chen1, Stephen A Runyan1, Michael R Robinson21Department of Biological Sciences, 2Ophthalmology Clinical Research, Allergan, Inc, Irvine, CA, USAIntroduction: Glaucoma is a multifactorial disease characterized by progressive optic nerve injury and visual field defects. Elevated intraocular pressure (IOP) is the most widely recognized risk factor for the onset and progression of open-angle glaucoma, and IOP-lowering medications comprise the primary treatment strategy. IOP elevation in glaucoma is associated with diminished or obstructed aqueous humor outflow. Pharmacotherapy reduces IOP by suppressing aqueous inflow and/or increasing aqueous outflow.Purpose: This review focuses on novel non-FDA approved ocular antihypertensive compounds being investigated for IOP reduction in ocular hypertensive and glaucoma patients in active clinical trials within approximately the past 2 years.Methods: The mode of IOP reduction, pharmacology, efficacy, and safety of these new agents were assessed. Relevant drug efficacy and safety trials were identified from searches of various scientific literature databases and clinical trial registries. Compounds with no specified drug class, insufficient background information, reformulations, and fixed-combinations of marketed drugs were not considered.Results: The investigational agents identified comprise those that act on the same targets of established drug classes approved by the FDA (ie, prostaglandin analogs and β-adrenergic blockers) as well as agents belonging to novel drug classes with unique mechanisms of action. Novel targets and compounds evaluated in clinical trials include an actin polymerization inhibitor (ie, latrunculin), Rho-associated protein kinase inhibitors, adenosine receptor analogs, an angiotensin II type 1 receptor antagonist, cannabinoid receptor agonists, and a serotonin receptor antagonist.Conclusion: The clinical value of novel compounds for the treatment of glaucoma will depend ultimately on demonstrating favorable efficacy and benefit-to-risk ratios relative to currently approved prostaglandin analogs and β-blockers and/or having complementary modes of action.Keywords: intraocular pressure, glaucoma progression, clinical trials, drug development, aqueous humor dynamics, antihypertensiv

The study of the epitaxial parameters on reliability of silicon planar devices technical summary report, 25 jun. 1964 - 25 jun. 1965

Effect of varying epitaxial deposition parameters on reliability of silicon planar solid state device

Division and subtraction by distinct cortical inhibitory networks in vivo

Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here we use a new platform for two-way light-based circuit interrogation in visual cortex in vivo to show the computational implications of modulating different subclasses of inhibitory neurons during sensory processing. We find that soma-targeting, parvalbumin-expressing (PV) neurons principally divide responses but preserve stimulus selectivity, whereas dendrite-targeting, somatostatin-expressing (SOM) neurons principally subtract from excitatory responses and sharpen selectivity. Visualized in vivo cell-attached recordings show that division by PV neurons alters response gain, whereas subtraction by SOM neurons shifts response levels. Finally, stimulating identified neurons while scanning many target cells reveals that single PV and SOM neurons functionally impact only specific subsets of neurons in their projection fields. These findings provide direct evidence that inhibitory neuronal subclasses have distinct and complementary roles in cortical computations.National Institutes of Health (U.S.) (Postdoctoral Fellowship)Simons Foundation (Postdoctoral Fellowship)National Institutes of Health (U.S.) (Predoctoral Fellowship

A millimeter-wave kinetic inductance detector camera for long-range imaging through optical obscurants

Millimeter-wave imaging provides a promising option for long-range target detection through optical obscurants such as fog, which often occur in marine environments. Given this motivation, we are currently developing a 150 GHz polarization-sensitive imager using a relatively new type of superconducting pair-breaking detector, the kinetic inductance detector (KID). This imager will be paired with a 1.5 m telescope to obtain an angular resolution of 0.09° over a 3.5° field of view using 3,840 KIDs. We have fully characterized a prototype KID array, which shows excellent performance with noise strongly limited by the irreducible fluctuations from the ambient temperature background. Full-scale KID arrays are now being fabricated and characterized for a planned demonstration in a maritime environment later this year

High resolution CMB power spectrum from the complete ACBAR data set

In this paper, we present results from the complete set of cosmic microwave background (CMB) radiation temperature anisotropy observations made with the Arcminute Cosmology Bolometer Array Receiver (ACBAR) operating at 150 GHz. We include new data from the final 2005 observing season, expanding the number of detector-hours by 210% and the sky coverage by 490% over that used for the previous ACBAR release. As a result, the band-power uncertainties have been reduced by more than a factor of two on angular scales encompassing the third to fifth acoustic peaks as well as the damping tail of the CMB power spectrum. The calibration uncertainty has been reduced from 6% to 2.1% in temperature through a direct comparison of the CMB anisotropy measured by ACBAR with that of the dipole-calibrated WMAP5 experiment. The measured power spectrum is consistent with a spatially flat, LambdaCDM cosmological model. We include the effects of weak lensing in the power spectrum model computations and find that this significantly improves the fits of the models to the combined ACBAR+WMAP5 power spectrum. The preferred strength of the lensing is consistent with theoretical expectations. On fine angular scales, there is weak evidence (1.1 sigma) for excess power above the level expected from primary anisotropies. We expect any excess power to be dominated by the combination of emission from dusty protogalaxies and the Sunyaev-Zel'dovich effect (SZE). However, the excess observed by ACBAR is significantly smaller than the excess power at ell > 2000 reported by the CBI experiment operating at 30 GHz. Therefore, while it is unlikely that the CBI excess has a primordial origin; the combined ACBAR and CBI results are consistent with the source of the CBI excess being either the SZE or radio source contamination.Comment: Submitted to ApJ; Changed to apply a WMAP5-based calibration. The cosmological parameter estimation has been updated to include WMAP

143 GHz brightness measurements of Uranus, Neptune, and other secondary calibrators with Bolocam between 2003 and 2010

Bolocam began collecting science data in 2003 as the long-wavelength imaging camera at the Caltech Submillimeter Observatory. The planets, along with a handful of secondary calibrators, have been used to determine the flux calibration for all of the data collected with Bolocam. Uranus and Neptune stand out as the only two planets that are bright enough to be seen with high signal-to-noise in short integrations without saturating the standard Bolocam readout electronics. By analyzing all of the 143 GHz observations made with Bolocam between 2003 and 2010, we find that the brightness ratio of Uranus to Neptune is 1.027 +- 0.006, with no evidence for any variations over that period. Including previously published results at \simeq 150 GHz, we find a brightness ratio of 1.029 +- 0.006 with no evidence for time variability over the period 1983-2010. Additionally, we find no evidence for time-variability in the brightness ratio of either Uranus or Neptune to the ultracompact HII region G34.3 or the protostellar source NGC 2071IR. Using recently published WMAP results we constrain the absolute 143 GHz brightness of both Uranus and Neptune to ~3%. Finally, we present ~3% absolute 143 GHz peak flux density values for the ultracompact HII regions G34.3 and K3-50A and the protostellar source NGC 2071IR.Comment: updated based on referee's comments, published in Ap