972 research outputs found

    The SLAC Comparator for the Calibration of Digital Leveling Equipment

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    At SLAC digital levels are used for precise leveling, both for setting out and monitoring. A very high precision of 30 {micro}m is required, which can only be achieved by regularly calibrating the leveling equipment. The calibration facility is also used for detailed investigations to refine the SLAC leveling procedure. In this paper the setup of the SLAC vertical comparator is described. In order to also perform traditional staff calibration a CCD camera was integrated into the SLAC comparator. Finally an overview of further investigations of our leveling equipment is presented

    Abundances of Baade's Window Giants from Keck/HIRES Spectra: II. The Alpha- and Light Odd Elements

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    We report detailed chemical abundance analysis of 27 RGB stars towards the Galactic bulge in Baade's Window for elements produced by massive stars: O, Na, Mg, Al, Si, Ca and Ti. All of these elements are overabundant in the bulge relative to the disk, especially Mg, indicating that the bulge is enhanced in Type~II supernova ejecta and most likely formed more rapidly than the disk. We attribute a rapid decline of [O/Fe] to metallicity-dependent yields of oxygen in massive stars, perhaps connected to the Wolf-Reyet phenomenon. he explosive nucleosynthesis alphas, Si, Ca and Ti, possess identical trends with [Fe/H], consistent with their putative common origin. We note that different behaviors of hydrostatic and explosive alpha elements can be seen in the stellar abundances of stars in Local Group dwarf galaxies. We also attribute the decline of Si,Ca and Ti relative to Mg, to metallicity- dependent yields for the explosive alpha elements from Type~II supernovae. The starkly smaller scatter of [/Fe] with [Fe/H] in the bulge, as compared to the halo, is consistent with expected efficient mixing for the bulge. The metal-poor bulge [/Fe] ratios are higher than ~80% of the halo. If the bulge formed from halo gas, the event occured before ~80% of the present-day halo was formed. The lack of overlap between the thick and thin disk composition with the bulge does not support the idea that the bulge was built by a thickening of the disk driven by the bar. The trend of [Al/Fe] is very sensitive to the chemical evolution environment. A comparison of the bulge, disk and Sgr dSph galaxy shows a range of ~0.7 dex in [Al/Fe] at a given [Fe/H], presumably due to a range of Type~II/Type~Ia supernova ratios in these systems.Comment: 51 pages, 6 tables, 27 figures, submitte

    The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.

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    Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzymatically inactive caspase-1 <sup>C284A</sup> , we provide genetic evidence that caspase-1 protease activity is required for canonical IL-1 secretion, pyroptosis, and inflammasome-mediated immunity. In caspase-1-deficient cells, caspase-8 can be activated at the inflammasome. Using mice either lacking the pyroptosis effector gasdermin D (GSDMD) or expressing caspase-1 <sup>C284A</sup> , we found that GSDMD-dependent pyroptosis prevented caspase-8 activation at the inflammasome. In the absence of GSDMD-dependent pyroptosis, the inflammasome engaged a delayed, alternative form of lytic cell death that was accompanied by the release of large amounts of mature IL-1 and contributed to host protection. Features of this cell death modality distinguished it from apoptosis, suggesting it may represent a distinct form of pro-inflammatory regulated necrosis

    Polyhedral units and network connectivity in calcium aluminosilicate glasses from high-energy x-ray diffraction

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    Structure factors for Cax/2AlxSi1-xO2 glasses (x=0,0.25,0.5,0.67) extended to a wave vector of magnitude Q= 40 1/A have been obtained by high-energy x-ray diffraction. For the first time, it is possible to resolve the contributions of Si-O, Al-O and Ca-O coordination polyhedra to the experimental atomic pair distribution functions (PDF). It has been found that both Si and Al are four-fold coordinated and so participate in a continuous tetrahedral network at low values of x. The number of network breaking defects in the form of non-bridging oxygens (NBO's) increases slowly with x until x=0.5 (NBO's ~ 10% at x=0.5). By x=0.67 the network breaking defects become significant as evidenced by the significant drop in the average coordination number of Si. By contrast, Al-O tetrahedra remain free of NBO's and fully integrated in the Al/Si-O network for all values of x. Calcium maintains a rather uniform coordination sphere of approximately 5 oxygen atoms for all values of x. The results suggest that not only Si/Al-O tetrahedra but Ca-O polyhedra, too, play a role in determining the glassy structure

    Evidence for charge localization in the ferromagnetic phase of La_(1-x)Ca_(x)MnO_3 from High real-space-resolution x-ray diffraction

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    High real-space-resolution atomic pair distribution functions of La_(1-x)Ca_(x)MnO_3 (x=0.12, 0.25 and 0.33) have been measured using high-energy x-ray powder diffraction to study the size and shape of the MnO_6 octahedron as a function of temperature and doping. In the paramagnetic insulating phase we find evidence for three distinct bond-lengths (~ 1.88, 1.95 and 2.15A) which we ascribe to Mn^{4+}-O, Mn^{3+}-O short and Mn^{3+}-O long bonds respectively. In the ferromagnetic metallic (FM) phase, for x=0.33 and T=20K, we find a single Mn-O bond-length; however, as the metal-insulator transition is approached either by increasing T or decreasing x, intensity progressively appears around r=2.15 and in the region 1.8 - 1.9A suggesting the appearance of Mn^{3+}-O long bonds and short Mn^{4+}-O bonds. This is strong evidence that charge localized and delocalized phases coexist close to the metal-insulator transition in the FM phase.Comment: 8 pages, 8 postscript figures, submitted to Phys. Rev.
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