The Asynergies of Structural Disaster Risk Reduction Measures: Comparing Floods and Earthquakes

Traditionally, building‐level disaster risk reduction (DRR) measures are aimed at a single natural hazard. However, in many countries the society faces the threat of multiple hazards. Building‐level DRR measures that aim to decrease earthquake vulnerability can have opposing or conflicting effects on flood vulnerability, and vice versa. In a case study of Afghanistan, we calculate the risk of floods and earthquakes, in terms of average annual losses (AAL), in the current situation. Next, we develop two DRR scenarios, where building‐level measures to reduce flood and earthquake risk are implemented. We use this to identify districts for which DRR measures of one hazard increase the risk of another hazard. We then also calculate the optimal situation between the two scenarios by, for each district, selecting the DRR scenario for which the AAL as a ratio of the total exposure is lowest. Finally, we assess the sensitivity of the total risk to each scenario. The optimal measure differs spatially throughout Afghanistan, but in most districts it is more beneficial to take flood DRR measures. However, in the districts where it is more beneficial to take earthquake measures, the reduction in risk is considerable (up to 40%, while flood DRR measures lead to a reduction in risk by 16% in individual districts). The introduction of asynergies between DRR measures in risk analyses allows policy‐makers to spatially differentiate building codes and other building‐level DRR measures to address the most prevalent risk while not compromising the risk resulting from other hazards

VizieR Online Data Catalog: ATESP 5 GHz radio survey. IV. (Ricci+, 2019)

(ATESP) survey for a complete sub-sample of Optical/IR Multi-band selected early-type radio galaxies are displayed in the ASCII table. The original survey data at 1.4 and 5GHz were published in Prandoni et al. (2000A&AS..146...41P, Cat. VIII/63) and Prandoni et al. (2006, Cat. J/A+A/457/517). A higher frequency follow-up at 5, 8 and 19 GHz was presented in Prandoni et al. (2010A&A...510A..42P). The flux densities of the 28 souces making up the early-type complete sub-sample observed in Sep 2011 and July 2012 follow-up campaigns with the Australia Telescope Compact Array (ATCA) at the radio frequencies of 19, 38 and 94 GHz are presented in the ASCII table. 2011 38-GHz flux densities are showed both at high- (HR: 0.6 arcsec) and low- (LR: 10-15 arcsec) angular resolutions

The AGN fuelling/feedback cycle in nearby radio galaxies - I. ALMA observations and early results

This is the first paper of a series exploring the multi-frequency properties of a sample of eleven nearby low excitation radio galaxies (LERGs) in the southern sky. We are conducting an extensive study of different galaxy components (stars, warm and cold gas, radio jets) with the aim of improving our understanding of the AGN fuelling/feedback cycle in LERGs. We present ALMA Band 6 $^{12}$CO(2-1) and continuum observations of nine sources. Continuum emission from the radio cores was detected in all objects. Six sources also show mm emission from jets on kpc/sub-kpc scales. The jet structures are very similar at mm and cm wavelengths. We conclude that synchrotron emission associated with the radio jets dominates the continuum spectra up to 230 GHz. The $^{12}$CO(2-1) line was detected in emission in six out of nine objects, with molecular gas masses ranging from $2 \times 10^{7}$ to $2 \times 10^{10}$ M$_{\rm \odot}$. The CO detections show disc-like structures on scales from $\approx$0.2 to $\approx$10 kpc. In one case (NGC 3100) the CO disc presents some asymmetries and is disrupted in the direction of the northern radio jet, indicating a possible jet/disc interaction. In IC 4296, CO is detected in absorption against the radio core, as well as in emission. In four of the six galaxies with CO detections, the gas rotation axes are roughly parallel to the radio jets in projection; the remaining two cases show large misalignments. In those objects where optical imaging is available, dust and CO appear to be co-spatial.Comment: Accepted for publication in MNRAS. The Appendix is provided as on-line only supplementary materia

Systematically Developing a Web-Based Tailored Intervention Promoting HPV-Vaccination Acceptability Among Mothers of Invited Girls Using Intervention Mapping.

Background: Currently, the eHealth field calls for detailed descriptions of theory-based interventions in order to support improved design of such interventions. This article aims to provide a systematic description of the design rationale behind an interactive web-based tailored intervention promoting HPV-vaccination acceptability. Methods: The 6-step Intervention Mapping (IM) protocol was used to describe the design rationale. After the needs assessment in Step 1, intervention objectives were formulated in Step 2. In Step 3, we translated theoretical methods into practical applications, which were integrated into a coherent intervention in Step 4. In Step 5, we anticipated future implementation and adoption, and finally, an evaluation plan was generated in Step 6. Results: Walking through the various steps of IM resulted in a detailed description of the intervention. The needs assessment indicated HPV-vaccination uptake remaining lower than expected. Mothers play the most important role in decision-making about their daughter's immunization. However, they generally feel ambivalent after they made their decisions, and their decisions are based on rather unstable grounds. Therefore, intervention objectives were to improve HPV-vaccination uptake and informed decision-making, and to decrease decisional conflict among mothers of invited girls. Computer-tailoring was chosen as the main method; virtual assistants were chosen as a practical application to deliver interactive tailored feedback. To maximize compatibility with the needs of the target group, a user-centered design strategy by means of focus groups and online experiments was applied. In these, prototypes were tested and sequentially refined. Finally, efficacy, effectiveness, and acceptability of the intervention were tested in a randomized controlled trial. Results showed a significant positive effect of the intervention on informed decision-making, decisional conflict, and nearly all determinants of HPV-vaccination uptake (P < 0.001). Mothers evaluated the intervention as highly positive. Discussion: Using IM led to an innovative effective intervention for promoting HPV-vaccination acceptability. The intervention maps will aid in interpreting the results of our evaluation studies. Moreover, it will ease the comparison of design rationales across interventions, and may provide leads for the development of other eHealth interventions. This paper adds to the plea for systematic reporting of design rationales constituting the process of developing interventions

GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice

Human HDR (hypoparathyroidism, deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear to what extent potential aberrations in the outer hair cells (OHCs) contribute to this disorder. To further elucidate the pathophysiological mechanism underlying the hearing defect in HDR-syndrome, we investigated the OHCs in heterozygous Gata3-knockout mice at both the functional and morphological level. While the signal-to-noise ratios of distortion product otoacoustic emissions (DPOAE) in wild type mice did not change significantly during the first half-year of live, those in the heterozygous Gata3 mice decreased dramatically. In addition, both light microscopic and transmission electron microscopic analyses showed that the number of OHCs containing vacuoles was increased in the mutants. Together, these findings indicate that outer hair cell malfunctioning plays a major role in the hearing loss in HDR-syndrome

The AGN fuelling/feedback cycle in nearby radio galaxies II. Kinematics of the molecular gas

This is the second paper of a series exploring the multicomponent (stars, warm and cold gas, and radio jets) properties of a sample of 11 nearby low-excitation radio galaxies, with the aim of better understanding the active galactic nuclei (AGN) fuelling/feedback cycle in these objects. Here, we present a study of the molecular gas kinematics of six sample galaxies detected in 12CO(2-1) with the Atacama Large Millimeter/submillimeter Array (ALMA). In all cases, our modelling suggests that the bulk of the gas in the observed (sub-)kpc CO discs is in ordered rotation. Nevertheless, low-level distortions are ubiquitous, indicating that the molecular gas is not fully relaxed into the host galaxy potential. The majority of the discs, however, are only marginally resolved, preventing us from drawing strong conclusions. NGC 3557 and NGC 3100 are special cases. The features observed in the CO velocity curve of NGC 3557 allow us to estimate a supermassive black hole (SMBH) mass of (7.10 ± 0.02) × 108 M⊙, in agreement with expectations from the MSMBH–σ* relation. The rotation pattern of NGC 3100 shows distortions that appear to be consistent with the presence of both a position angle and an inclination warp. Non-negligible radial motions are also found in the plane of the CO disc, likely consistent with streaming motions associated with the spiral pattern found in the inner regions of the disc. The dominant radial motions are likely to be inflows, supporting a scenario in which the cold gas is contributing to the fuelling of the AGN

Fibrodysplasia Ossificans Progressiva: what have we achieved and where are we now? follow-up to the 2015 Lorentz Workshop

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare progressive genetic disease effecting one in a million individuals. During their life, patients with FOP progressively develop bone in the soft tissues resulting in increasing immobility and early death. A mutation in the ACVR1 gene was identified as the causative mutation of FOP in 2006. After this, the pathophysiology of FOP has been further elucidated through the efforts of research groups worldwide. In 2015, a workshop was held to gather these groups and discuss the new challenges in FOP research. Here we present an overview and update on these topics