Domperidone induced galactorrhea: rare presentation of a common drug

Domperidone is one of the cheapest and also effective anti-emetic drugs which is very commonly used as an over-the-counter drug. Galactorrhoea is a rare side effect of domperidone. We report a case of a female patient who was prescribed domperidone for migraine headache with vomiting. While taking the drug, she developed galactorrhoea, and after discontinuing domperidone therapy, her galactorrhoea subsided

Rosuvastatin induced gynecomastia: a rare presentation of newer statin

Gynecomastia is a common benign disease characterized by the progressive enlargement of the glandular tissue of the male breast. The etiology may vary and may be physiological, pharmacological, pathological, or even idiopathic. Among men, drug induced gynecomastia may account for 10-20% of cases. Several case reports have associated this condition to the use of statins. However, there are few case reports of rosuvastatin induced gynecomastia have been reported in literature. We describe a 45-year-old male who developed bilateral gynecomastia after one month of rosuvastatin therapy, after switching to a different or less potent statin (atorvastatin), his symptoms resolved with-in one month. Use of the Naranjo adverse drug reaction probability scale indicated a possible relationship between the patient’s development of gynecomastia and rosuvastatin therapy

Multi-level banking regulatory landscape:Crisis & opportunities to lobby for trade associations

Units prefer to work collectively and in groups. Units of humans working together create synergy and division of labour whilst ensuring safety and protection. This is, perhaps, one of our most consequential discoveries. Pursuing objectives by working collectively and sharing responsibilities has enabled us to leave nomadic life behind and lay the roots of modern civilisation. Needless to say, this discovery has been systemically applied to institutions and structures created in almost every facet of the modern economy globally. Since the dawn of minted paper money, banks have occupied the centre-stage in a nation’s economy. We no longer live in a world where a few wealthy goldsmiths or merchants function as a bank for travellers and traders. In the neoliberal world of the twenty-first century, private and semi-private banks have become commonplace. Banking transactions have become increasingly creative and complex. The increasing complexity can be partly attributed to the advent of cross-border transactions, open borders and globalisation in the last century, the expansion of the role of and services provided by banks. Thus, banks become a member of associations to speak collectively on common issues, organise common interests efficiently, and service and protect each other.Business or trade associations that represent the interests of banks emerged in the twentieth century and have been on a fascinating journey ever since. From merely providing a platform for banks for various purposes, trade associations became powerful advocacy and lobby groups. In the last five decades, trade associations have become a focal point of collective interests of banks and financial firms. Trade associations have been the preferred intermediary between the private sector in banking and finance and regulators. Trade associations have become an important body that advocates and lobbies for the banks in international and domestic policy and regulatory circles. Banks and trade associations that represent the interests of banks came under scrutiny in the aftermath of the Financial Crisis of 2007-08. A prominent criticism asserted that excessive lobbying by these non-state actors led to the adoption of weaker regulations that failed to maintain financial stability and prevent the erosion of wealth. Despite these criticisms, it has been observed that trade associations have continued to stay relevant for their stakeholders, especially regulators. Therefore, this dissertation embarks upon a quest to decipher the reasons that have led to trade associations occupying such privileged positions despite the challenges posed by crises that occurred. This dissertation discusses the impact of the Financial Crisis of 2007-08 on the regulatory landscape under which banks and trade associations operate. This research inquires whether the banking regulatory landscape creates incentives for trade associations to pursue their objectives continually. Further, this work studies the trade associations' characteristics, and the decisions they take that allow them to pursue their objectives continually. This dissertation concludes that the banking regulatory landscape generates demand for engagement by trade associations. Additionally, this research finds that certain trade associations can keep up with this demand by changing their internal characteristics, governance and manner of operating and/ or by adopting certain strategies. The novelty and the contribution of this research lie in the interdisciplinary approach adopted by the dissertation towards understanding forces that enable, lead to and allow non-state actors, particularly trade associations, to pursue their objectives continually and, as a result, remain relevant continually for its stakeholders including regulators engaged in rule-making. This dissertation brings together theoretical literature from political economy, organisational and management studies, transnational regulatory networks, and transnational private rule-making to comprehend the privileged position enjoyed by trade associations. The research is conducted as a two-part case study; the first undertakes a study of the regulatory banking landscape and incentives or opportunities for trade associations to engage with the regulators (both before and after the Crisis). The second case study is the analysis of a set of trade associations and their internal characteristics and decisions or strategies adopted by them to enable their continued relevance for the regulators. The impact of the Financial Crisis of 2007-08 is explored for both sets of case studies. The research is conducted by relying on primary and secondary sources. Officials occupying key positions in the regulatory bodies and trade associations are interviewed to provide insights that have not been reported before. Therefore, this dissertation accords an opportunity to develop a more nuanced understanding of the implications of the regulatory landscape in banking

Atrial fibrillation: a rare but probable adverse effect of sildenafil

Knowledge of the cardiovascular effects of sildenafil is important for a number of reasons. The main risk factors for the erectile dysfunction (hypercholesterolemia, hypertension, diabetes, smoking) are the same as those for coronary artery disease. The reported cardiovascular side effects of sildenafil in normal healthy population are minor and mainly associated with vasodialation (i.e. headache, flushing and small decrease in systolic and diastolic blood pressure). Authors report the occurrence of atrial fibrillation after the use of sildenafil in a normal healthy individual. To the best of our knowledge, there are only few case reports in the literature showing occurrence of atrial fibrillation with use of sildenafil

Nobel Laureate Jeffrey C Hall: A Scientometric Portrait

Present Study analysis 201 publications (1972-2008) of Nobel laureate Jeffrey C Hall, an American eminent scientist in geneticist. His publications received 18,896 citations and first paper was reported in Scopus in 1972, subsequently, he published 200 research papers in various journals. The collaboration coefficient of scientist is 0.89 and forty-three (43) are two authored publications, 22 are single authored, scientist has authored highest publication in decade III (1990-1999) with 81(40.30%) publications. The paper entitled A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila” published in \u27Cell\u27 journal in 2000 has been cited highest 632 times with ranked 1 among all his publications. Study reveals out of 201 publications 193 (96.02%) papers are obtained all 18896 citations, and top 20(9.95%) publications are obtained 7566(40.04%) citations, and cited more than 200 times, scientist preferred 50 channel of communications are used to publish his research output, most publications 28(13.93%) were published in \u27Genetics\u27 (IF: 4.556) journa

Effect of composition and depth of filter-bed on the efficiency of Sand-intermittent-filter treating the Industrial wastewater at Haridwar, India

Sand Intermittent Filtration (SIF) is an established technology of wastewater treatment and in recent years it gains renewed interest due to its simplicity and less energy requirement. The aim of the present study was to evaluate the modified filter-bed Reactor using Sand-intermittent-filtration (SIF) for the removal of physicochemical parameters viz dissolved oxygen (DO), biochemical oxygen demand (BOD), chemical oxygen demand (COD), total hardness (TH), calcium hardness (CaH), chloride (Cl), turbidity, total solids (TS), total dissolved solids (TDS), and total suspended solids (TSS) of the Industrial wastewater of State Industrial Development Corporation of Uttarakhand Limited (SIDCUL) at Haridwar. The experiments were performed with the composition of the filter-bed having sand and gravel in the ratio of 1:1 (Reactor I); 1:2 (Reactor II) and 2:1 (Reactor III) at the room temperature 300C. Each Reactor was categorized into A, B and C type based on depth of filter-bed (A=10 cm, B=15 cm, C=30 cm). The maximum removal of TS (52.21%), TDS (50.66%), TSS (57.20%), turbidity (67.36%), chloride (28.81%), BOD (39.18%), COD (38.66%), TH (53.40%), and CaH (62.57%) was observed in Reactor II C (soil and gravel- 2:1 and 30 cm depth of bed) using 0.49 mm effective size and 0.49 uniformity coefficient (UC) of the sand. A mixture of sand and gravel in the Reactor II with a ratio of 2:1 yielded better efficiency in comparison to the Reactor I and Reactor III. Thus, SIF technology could be environment-friendly and economically cost-effective for removing various physicochemical parameters from Industrial wastewater

Nobel Laureate Michael Morris Rosbash : A scientometric portrait

Present Study analysis 201 publications (1972-2008) of Nobel laureate Jeffrey C Hall, an American eminent scientist in geneticist. His publications received 18,896 citations and first paper was reported in Scopus in 1972, subsequently, he published 200 research papers in various journals. The collaboration coefficient of scientist is 0.89 and forty-three (43) are two authored publications, 22 are single authored, scientist has authored highest publication in decade III (1990-1999) with 81(40.30%) publications. The paper entitled A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila” published in \u27Cell\u27 journal in 2000 has been cited highest 632 times with ranked 1 among all his publications. Study reveals out of 201 publications 193 (96.02%) papers are obtained all 18896 citations, and top 20(9.95%) publications are obtained 7566(40.04%) citations, and cited more than 200 times, scientist preferred 50 channel of communications are used to publish his research output, most publications 28(13.93%) were published in \u27Genetics\u27 (IF: 4.556) journal

Acute ST-elevation myocardial infraction after use of oral sumatriptan: a rare presentation

Sumatriptan is an agonist of 5-hydroxytryptamine type-1 (5HT1) receptors that is widely used as a migraine abortant; however, there have been studies showing angina, coronary vasospasm, and even myocardial infraction in patients with predisposing cardiac risk factors. We present the case of a female patient with no cardiovascular risk factor who developed ST-elevation myocardial infraction 30 minutes after ingesting oral sumatriptan for her migraine

Assessment of soil quality at selected sites around Karwi town, Chitrakoot (Uttar Pradesh), India

Every living organism on this planet prioritises food. Sustainable crop production is the need of the present hour to fulfil the basic needs of the large population of the country. The production of any crop, along with many other factors, largely depends on the soil quality of the area. Therefore, the aim of the present study is to ascertain the quality of the soil in the study area. To fulfil the aim of the present study, four sites {Karwi Mafi (SS-1), Karwi (SS-2), Amanpur (SS-3), and Narainpur (SS-4)} were selected around Karwi town, Chitrakoot (Uttar Pradesh), India. The soil samples were collected from the selected sites following the Grab sampling method for 12 months (January 2021 to December 2021). A total of 80 soil samples were collected and analysed for various physical parameters, primary and secondary nutrients, micronutrients, and heavy metals. The results obtained showed that soil moisture ranged from 44.56% to 48.12%. Among all the four sites, the soil quality of SS-03 (pH=6.79±0.03) was observed to be slightly acidic in nature. Phosphorous ranged from 48.10 to 56.53 mg/kg. Similarly, all other studied primary and secondary nutrients were observed in sufficient quantity at all the study sites. The concentration of all the studied micronutrients (Cd, Cu, Mn, Zn, and Fe) ranged from 0.95-1.31 mg/kg, 4.39-5.23 mg/kg, 2.47-3.62 mg/kg, 14.29-21.42 mg/kg, and 4.83-6.01 mg/kg, respectively. Chromium ranged from 0.96 to 1.58 mg/kg. On the basis of the present study, it can be concluded that the quality of soil in the study area is in good condition. The findings of the present study are important as they reveal the soil quality of pure residential and agricultural areas without any anthropogenic or natural dumping of solid or liquid waste