An open access geospatial database for the sub-Antarctic Prince Edward Islands

Researchers of projects at the sub-Antarctic Prince Edward Islands are increasingly considering geospatial data as an essential component in answering scientific questions. A need exists for high-resolution geospatial data in both multi- and transdisciplinary research to better analyse fine-scale biotic–abiotic interactions of the Islands’ landscape and ecosystems within the context of climate change and the impacts of invasive species. However, much of the geospatial data that currently exist have limitations in spatial coverage and/or resolution, are outdated, or are not readily available. To address these issues, we present an online geospatial database for the Prince Edward Islands (both islands) produced from a high-resolution digital surface model and satellite imagery. This database contains vector files, raster data sets, and maps of topographical and hydrological parameters. It is freely available to download from Figshare – an open access data repository. We encourage the South African polar science community to make use of similar platforms for improved data sharing practices. Significance: A topographical and hydrological geospatial database – produced from a 1 m x 1 m digital surface model of the Prince Edward Islands – is provided. These fine-scale geospatial data allow for a more comprehensive assessment of biotic–abiotic interactions at an island scale. Also included are locality maps specifying place names and established long-term marine mammal monitoring beaches and coastal zones for improved cross-referencing. The dataset is downloadable from an open access data repository and intended to promote open science and data sharing practices

Fur seal populations facilitate establishment of exotic vascular plants

The cessation of seal harvesting has prompted a recovery of previously decimated fur seal (Arctocephalus gazella and Arctocephalus tropicalis) populations across the Southern Ocean region. Although the associated increase in seal-related soil disturbance is known to impact indigenous vegetation, the effect of increasing fur seal numbers on exotic plant species is not yet clear. Here, we compare plant species composition and cover between 26 sites with high fur seal impact paired with nearby control sites on sub- Antarctic Marion Island. Seal-affected sites had a significantly higher number and cover of exotic plants, specifically of the widespread sub-Antarctic invaders, Poa annua and Sagina procumbens, than control sites. Furthermore, some of the native species, most notably the disturbance-sensitive species, Blechnum penna-marina, were significantly less abundant in seal-affected sites compared to controls. We propose that this is a result of both physical trampling, which opens up niches for exotics by damaging natives, and nutrient enrichment of the soils, giving exotic species a competitive advantage over natives. While other studies have noticed associations between exotic plant species and indigenous animal disturbance, this is, to the best of our knowledge, the first study to empirically show that the successful recovery of fur seal populations can have undesirable side-effects such as the enhanced persistence of exotic plant species. We recommend that alien plant management plans specifically include areas of increased animal disturbance into their programmes.http://www.elsevier.com/ locate/bioconhb201

An open access geospatial database for the sub-Antarctic Prince Edward Islands

Researchers of projects at the sub-Antarctic Prince Edward Islands are increasingly considering geospatial data as an essential component in answering scientific questions. A need exists for high-resolution geospatial data in both multi- and transdisciplinary research to better analyse fine-scale biotic–abiotic interactions of the Islands’ landscape and ecosystems within the context of climate change and the impacts of invasive species. However, much of the geospatial data that currently exist have limitations in spatial coverage and/or resolution, are outdated, or are not readily available. To address these issues, we present an online geospatial database for the Prince Edward Islands (both islands) produced from a high-resolution digital surface model and satellite imagery. This database contains vector files, raster data sets, and maps of topographical and hydrological parameters. It is freely available to download from Figshare – an open access data repository. We encourage the South African polar science community to make use of similar platforms for improved data sharing practices. SIGNIFICANCE : • A topographical and hydrological geospatial database – produced from a 1 m x 1 m digital surface model of the Prince Edward Islands – is provided. • These fine-scale geospatial data allow for a more comprehensive assessment of biotic–abiotic interactions at an island scale. • Also included are locality maps specifying place names and established long-term marine mammal monitoring beaches and coastal zones for improved cross-referencing. • The dataset is downloadable from an open access data repository and intended to promote open science and data sharing practices.DATA AVAILABILITY: Dataset posted on 29.09.2022, 10:09 authored by Elizabeth Rudolph, David William Hedding, Nico De Bruyn and Werner Nel. This database contains vector files, raster datasets, and maps of topographical and hydrological parameters of the sub-Antarctic Prince Edward Islands. Data production procedures are described in the associated paper (see references below) and the metadata are described in the "README" word document. The data is intended for scientific and/or educational use. (https://figshare.com/articles/dataset/Prince_Edward_Islands_geospatial_database/19248626)South African National Research Foundationhttp://www.sajs.co.zahj2022Mammal Research InstituteZoology and Entomolog

A glacial chronology for sub-Antarctic Marion Island from MIS 2 and MIS 3

It is increasingly apparent that local and regional factors, including geographic location, topography and climatic variability, strongly influence the timing and extent of glaciations across the Southern Hemisphere. Glacial chronologies of sub-Antarctic islands can provide valuable insights into the nature of regional climatic variability and the localised response(s) of glacial systems during periods of climatic change. With new cosmogenic 36Cl exposure ages from Marion Island in the southern Indian Ocean, we provide the oldest dated terrestrial moraine sequences for the sub-Antarctic islands. Results confirm that a local Last Glacial Maximum was reached prior to ∼56 ka when ice retreated with localised stand still events at ∼43 ka and between ∼38 and 33 ka. Evidence of ice re-advances throughout MIS 2 are limited and particularly absent for the cooling periods at ∼32 and ∼21 ka, and retreat continued until ∼17 ka ago. Any MIS 1 readvances on the island would be confined to altitudes above 900 m a.s.l. but the Holocene exposure ages remains to be documented. We compare Marion Island's glacial chronology with other sub-Antarctic islands (e.g., the Kerguelen archipelago, Auckland and Campbell islands and South Georgia) and review the evidence for a Southern Hemisphere glacial maximum in late MIS 3 (∼41 ka). At a regional scale we recognize sea surface temperatures, sea ice extent and the latitudinal position of the Southern Westerly Wind belt as key controls on equilibrium-line altitudes and ice accumulation due to their influence on air temperature and precipitation regimes. At an island scale, geomorphological mapping shows that deglaciation of individual glacier lobes was a-synchronous due to local physiographical and topographical factors controlling the island's micro-climate. We suggest that variability in deglaciation chronologies at smaller scales (particularly at the sub-Antarctic Islands) are important to consider when untangling climatic drivers across the Southern Ocean

Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium

Liver X receptors (LXRs) are li-gand-dependent transcription factors activated by cholesterol metabolites. These receptors induce a suite of target genes required for de novo synthesis of triglycerides and cholesterol transport in many tissues. Two different isoforms, LXRβ and LXRβ, have been well characterized in liver, adipocytes, macrophages, and intestinal epithelium among others, but their contribution to cholesterol and fatty acid efflux in the lactating mammary epithelium is poorly understood. We hypothesize that LXR regulates lipogenesis during milk fat production in lactation. Global mRNA analysis of mouse mammary epithelial cells (MECs) revealed multiple LXR/RXR targets upregulated sharply early in lactation compared with midpregnancy. LXRβ is the primary isoform, and its protein levels increase throughout lactation in MECs. The LXR agonist GW3965 markedly induced several genes involved in cholesterol transport and lipogenesis and enhanced cytoplasmic lipid droplet accumulation in the HC11 MEC cell line. Importantly, in vivo pharmacological activation of LXR increased the milk cholesterol percentage and induced sterol regulatory element-binding protein 1c (Srebp1c) and ATP-binding cassette transporter a7 (Abca7) expression in MECs. Cumulatively, our findings identify LXRβ as an important regulator of cholesterol incorporation into the milk through key nodes of de novo lipogenesis, suggesting a potential therapeutic target in women with difficulty initiating lactation.Fil: Grinman, Diego Yair. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Careaga Quiroga, Valeria Pilar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wellberg, Elizabeth A.. University of Colorado; Estados UnidosFil: Dansey, Maria Virginia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kordon, Edith Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Anderson, Steven M.. University of Colorado; Estados UnidosFil: Maier, Marta Silvia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Burton, Gerardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: MacLean, Paul S.. University of Colorado; Estados UnidosFil: Rudolph, Michael C.. University of Colorado; Estados UnidosFil: Pecci, Adali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentin

Aβ Vaccination in Combination with Behavioral Enrichment in Aged Beagles: Effects on Cognition, Aβ, and Microhemorrhages

Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer’s disease (AD). Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1–42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11–12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); (4) ENR and VAC (E/V) and treated for 20 months. VAC decreased brain Aβ, pyroglutamate Aβ, increased CSF Aβ42 and BDNF RNA levels but also increased microhemorrhages. ENR reduced brain Aβ and prevented microhemorrhages. The combination treatment resulted in a significant maintenance of learning over time, reduced Aβ and increased BDNF mRNA despite increased microhemorrhages, however there were no benefits to memory. These results suggest that the combination of immunotherapy with behavioral enrichment leads to cognitive maintenance associated with reduced neuropathology that may benefit people with AD

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC

PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

UBVRI Light Curves of 44 Type Ia Supernovae

We present UBVRI photometry of 44 type-Ia supernovae (SN Ia) observed from 1997 to 2001 as part of a continuing monitoring campaign at the Fred Lawrence Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics. The data set comprises 2190 observations and is the largest homogeneously observed and reduced sample of SN Ia to date, nearly doubling the number of well-observed, nearby SN Ia with published multicolor CCD light curves. The large sample of U-band photometry is a unique addition, with important connections to SN Ia observed at high redshift. The decline rate of SN Ia U-band light curves correlates well with the decline rate in other bands, as does the U-B color at maximum light. However, the U-band peak magnitudes show an increased dispersion relative to other bands even after accounting for extinction and decline rate, amounting to an additional ~40% intrinsic scatter compared to B-band.Comment: 84 authors, 71 pages, 51 tables, 10 figures. Accepted for publication in the Astronomical Journal. Version with high-res figures and electronic data at http://astron.berkeley.edu/~saurabh/cfa2snIa

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

SummaryAlzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Aβ42 levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and Notch intracellular domains, respectively. These compounds also reduced Aβ40 levels while concomitantly elevating levels of Aβ38 and Aβ37. Immobilization of a potent GSM onto an agarose matrix quantitatively recovered Pen-2 and to a lesser degree PS-1 NTFs from cellular extracts. Moreover, oral administration (once daily) of another potent GSM to Tg 2576 transgenic AD mice displayed dose-responsive lowering of plasma and brain Aβ42; chronic daily administration led to significant reductions in both diffuse and neuritic plaques. These effects were observed in the absence of Notch-related changes (e.g., intestinal proliferation of goblet cells), which are commonly associated with repeated exposure to functional gamma-secretase inhibitors (GSIs)