The last stand before MAP: cosmological parameters from lensing, CMB and galaxy clustering

Cosmic shear measurements have now improved to the point where they deserve to be treated on par with CMB and galaxy clustering data for cosmological parameter analysis, using the full measured aperture mass variance curve rather than a mere phenomenological parametrization thereof. We perform a detailed 9-parameter analysis of recent lensing (RCS), CMB (up to Archeops) and galaxy clustering (2dF) data, both separately and jointly. CMB and 2dF data are consistent with a simple flat adiabatic scale-invariant model with Omega_Lambda=0.72+/-0.09, omega_cdm=0.115+/- 0.013, omega_b=0.024+/-0.003, and a hint of reionization around z~8. Lensing helps further tighten these constraints, but reveals tension regarding the power spectrum normalization: including the RCS survey results raises sigma8 significantly and forces other parameters to uncomfortable values. Indeed, sigma8 is emerging as the currently most controversial cosmological parameter, and we discuss possible resolutions of this sigma8 problem. We also comment on the disturbing fact that many recent analyses (including this one) obtain error bars smaller than the Fisher matrix bound. We produce a CMB power spectrum combining all existing experiments, and using it for a "MAP versus world" comparison next month will provide a powerful test of how realistic the error estimates have been in the cosmology community.Comment: Added references and Fisher error discussion. Combined CMB data, window and covariance matrix for January "MAP vs World" contest at http://www.hep.upenn.edu/~max/cmblsslens.html or from [email protected]

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Excursion en fosse vocontienne (25-28 mai 1988)

International audienceEustatisme et séquences de dépôt dans le Crétacé du Sud-Est de la Franc

Channelized sandstone bodies (« Cordons ») in the Tassili N’Ajjer (Algeria & Libya) : snapshots of a Late Ordovician proglacial outwash plain.

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Lower Palaeozoic unconformities in an intracratonic platform setting: Glacial erosion vs. tectonics in the eastern Murzuq Basin (southern Libya).

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Discusion “Depositional dynamics of glaucony-rich deposits in the Lower Cretaceous of the Nice arc, southeast France” (Cretaceous Research 25(2004):179-489), Discussion

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Paleovalley and fault-controlled depocentres in the Late-Ordovician glacial record of the Murzuq Basin (central Libya).

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