STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane

Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on the effects of β-hexaclorocyclohexane (β-HCH), a widely common pollutant. A detailed epidemiological study carried out on exposed population in the “Valle del Sacco” found correlations between the incidence of a wide range of diseases and the occurrence of β-HCH contamination. Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by β-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. Materials and Methods: Human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cell lines were treated with 10 µM β-HCH in the presence or absence of specific inhibitors for different receptors. All samples were subjected to analysis by immunoblotting and RT-qPCR. Results and Conclusions: The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to β-HCH. Moreover, we ascertained the role of STAT3 as a master regulator of energy metabolism via the altered expression and localization of HIF-1α and PKM2, respectively, resulting in a Warburg-like effect

Changing structures in transnational research networks: an analysis of the impact of COVID-19 on China's scientific collaborations

Research networks play pivotal roles in the creation and diffusion of knowledge. It is widely acknowledged that frontier research tends to cluster around transnational research networks (TRNs), which also represent strategic tools for nurturing innovation in R&D-intensive companies. Therefore, they are crucial for promoting the rapid development of the knowledge economy in underdeveloped countries. In this context, China's experience is particularly relevant because the country has invested heavily in knowledge production, which is arguably one of the most important structural changes at the global level in recent decades, with important implications for the division of labor and trade among countries. The country has been investing in order to become the scientific world leader, and in this transition, research collaboration, in particular with other countries, can become strategic. In this work, we analyze whether COVID-19 and related research have affected the shape of the network and the intensity of collaborations involving China in the field of health studies, comparing it to the case of the U.S. as the global leader in research (Fry et al., 2020). In particular, we wish to assess whether COVID-19-related research has pushed toward larger and more intensive collaborations internationally than before the pandemic or whether a tendency to closure has prevailed has prevailed. This also means understanding whether COVID-19, as a global phenomenon, has affected China in rising as an international research leader. To do so, we built an original dataset of international, coauthored publications involving China or the U.S. in selected health research fields. Our analysis first shows that COVID-19 research has assumed specific features distinct from other topics in the same research field, shaping research networks in a peculiar way for both China and the U.S. Second, for China, COVID-19 does not appear to have represented an opportunity to further climb up the international research ladder, as it has attracted a relatively low and more volatile number of collaborators from different countries

Development of prejudice against immigrants and ethnic minorities in adolescence: A systematic review with meta-analysis of longitudinal studies

Previous research highlighted that prejudice is already formed in early childhood, reaches a peak in middle childhood, and slightly decreases in late childhood, whereas the development of prejudice in adolescence was mostly unknown. This systematic review with meta-analysis aimed to comprehensively summarize and integrate prior longitudinal research on adolescents’ prejudice to address two main research questions: (a) how does prejudice develop in adolescence? (b) which factors are related to holding prejudicial attitudes in adolescence? Using multiple search strategies and applying a two-step selection process, a final set of 26 journal articles including a total of 30 samples (N = 23,513 participants) was found to match eligibility criteria and, thus, was included in the review. The meta-analytic findings highlighted that (a) prejudice does not change in adolescence; (b) interindividual differences in prejudice are well-established, they become increasingly strong with age, and they are inversely related to the time-lag between assessments; and (c) several individual, identity, and contextual factors are related to prejudice in different ways. More specifically, social dominance orientation, intergroup anxiety, identification with the national ingroup, and parental prejudice contributed to increasing later levels of adolescents’ prejudice, whereas intergroup friendship contributed to lessening it. Importantly, prejudice had comparable reverse effects on these factors, pointing to consistent bidirectional associations. These main findings are discussed considering their implications for future research and practice

Unfolding political attitudes through the face: facial expressions when reading emotion language of left- and right-wing political leaders

Spontaneous emotionally congruent facial responses (ECFR) to others\u2019 emotional expressions can occur by simply observing others\u2019 faces (i.e., smiling) or by reading emotion related words (i.e., to smile). The goal of the present study was to examine whether language describing political leaders\u2019 emotions affects voters by inducing emotionally congruent facial reactions as a function of readers\u2019 and politicians\u2019 shared political orientation. Participants read sentences describing politicians\u2019 emotional expressions, while their facial muscle activation was measured by means of electromyography (EMG). Results showed that reading sentences describing left and right-wing politicians \u201csmiling\u201d or \u201cfrowning\u201d elicits ECFR for ingroup but not outgroup members. Remarkably, ECFR were sensitive to attitudes toward individual leaders beyond the ingroup vs. outgroup political divide. Through integrating behavioral and physiological methods we were able to consistently tap on a \u2018favored political leader effect\u2019 thus capturing political attitudes towards an individual politician at a given moment of time, at multiple levels (explicit responses and automatic ECFR) and across political party membership lines. Our findings highlight the role of verbal behavior of politicians in affecting voters\u2019 facial expressions with important implications for social judgment and behavioral outcomes

Identities: A developmental social-psychological perspective

In this contribution, we review research that uses a cross-fertilisation approach to integrate developmental and social-psychological perspectives on how identities are formed and changed over time and how identity processes are genuinely social, being embedded in social contexts and fed by social contents. First, we outline the three-factor identity model as a parsimonious approach to understanding the dynamics of identity development. Second, we review empirical studies with longitudinal approaches to shed light on how identity processes are embedded in key contexts such as family, friendships and society at large through behaviours such as civic engagement. Third, we discuss the interplay between personal and social identities. We conclude by highlighting how adopting a cross-fertilisation approach that combines social-psychological and developmental perspective can significantly advance the theoretical understanding of identity dynamics. Finally, we address similarities and differences between personal identity and social identity approaches, and we provide an agenda for future research

Strontium-Substituted α-TCP: Structure, Stability, and Reactivity in Solution

& alpha;-Tricalcium phosphate (& alpha;-TCP) is widelyused as acomponent of bone cements, and many efforts have been made to dopeit with strontium ion (Sr), which is known for its beneficial rolein bone tissue. However, the range of possible substitution of strontiumfor calcium (Ca) into & alpha;-TCP, as well as its effect on the & alpha;-TCPstructure, has not been clarified yet. Herein, we investigate thissubstitution through the examination of & alpha;-TCP synthesized athigh temperatures in the presence of increasing amounts of strontiumaccording to two different routes: 1-step and 2-steps. The results show that Sr can enter into an & alpha;-TCPstructure up to about 10 atom % and substitutes for calcium mostlyat specific cation sites, namely, M(5), M(11), and M(17), characterizedby relatively low bond valence sums and long mean Ca-O distance.Strontium presence stabilizes & alpha;-TCP delaying its transformationinto octacalcium phosphate and hydroxyapatite in H3PO4, as well as in physiological solution. Although the two methodsof synthesis provide similar structural results, the products of 1-step synthesis display a slightly smaller crystallitesize and greater solubility and, as a consequence, a faster hydrolysisreaction.& alpha;-Tricalcium phosphatepreparation through the solid-statereaction is described following two different procedures. The investigationof the range of possible substitution of strontium for calcium into & alpha;-TCP as well as its effect on the & alpha;-TCP structure ispresented. Furthermore, it is shown that strontium presence stabilizes & alpha;-TCP and delays its hydrolysis reaction into octacalcium phosphateand hydroxyapatite

Lapex: A Phoswich balloon experiment for hard X-ray astronomy

Satellite and balloon observations have shown that several classes of celestial objects are hard ( 15 keV) energy band with a sensitivity of approx 10 mCrab has been performed with the UCSD/MIT instrument (A4) on board the HEAO 1 satellite. About 70 X-ray sources were detected, including galactic and extragalactic objects. Hard X-ray emission has been detected in the Galaxy from X-ray pulsars. Extragalactic sources of hard X-ray emission include clusters of galaxies, QSOs, BL Lac objects, Seyfert galaxies. The essential characteristics of the Large Area Phoswich Experiment (LAPEX) for crowded sky field observations are described. It has: (1) a broad energy band of operation (20-300 keV); (2) a 3 sigma sensitivity of about 1 mCrab in 10,000 s of live observing time; and (3) imaging capabilities with an angular resolution of about 20'

Nonpuerperal inversion of uterus secondary to leiomyoma in menopause: a rare case report

Inversion of uterus is a rare clinical condition if not associated with third stage of labor or puerperium. Non-puerperal uterine inversion usually occurs secondary to tumor arising from the fundus of uterus. We report an unusual case of non-puerperal uterine inversion caused by large submucous fibroid in a 65 year old postmenopausal woman which was managed by combined abdomino-perineal approach

Heterogeneous effects of spinoff foundations on the means of technology transfer: the role of past academic-industry collaborations

Focusing on the Italian population of academic entrepreneurs, we analyze the effect of establishing a spinoff firm on researchers' attitudes towards carrying out other activities in collaboration with firms, namely, co-publishing and co-patenting. We investigate the heterogeneity in this effect in terms of existing collaborations with firms in the pre-spinoff period. Using a counterfactual analysis on subgroups, we verify that academic entrepreneurs with previous publications with firms diminish their co-publishing and increase their co-patenting after founding a spinoff. Conversely, academic entrepreneurs who had no previous publications with firms increase their co-publishing and decrease their co-patenting. We maintain that such results are related to academics' learning processes connected with their previous technology transfer activities. The policy implications are related to technology transfer aims and contradict the idea that promoting spinoffs is an appropriate "one-size-fits-all" initiative

Developmental trajectories of ethnic and national identities in adolescents from migrant families: The role of social identification with family and classmates

Given that adolescents from migrant families live within at least two cultural contexts (i.e., the heritage and the destination cultures), they generally must negotiate and construct ethnic and national identities. Accordingly, the present three-wave longitudinal study was designed to identify distinct developmental trajectories of ethnic and national identities among adolescents from migrant families (n = 244, 56.6% female; Mage = 14.90, SDage = 0.84 at Time 1). Multivariate latent class growth analyses indicated that participants could be classified into one of four groups based on their identity profiles: ethnic-oriented identity, national-oriented identity, dual identity, and marginalized identity. Further, social identification with family and classmates was examined as a predictor of memberships in these distinct identity profiles. Results of multinomial logistic regression analysis indicated that greater social identification with family increased the probability of being classified into the ethnic-oriented and dual identity profiles rather than into the marginalized identity profile, whereas greater social identification with classmates increased the likelihood of being classified into either national-oriented or dual identity profiles rather than into the marginalized identity profile. These findings provide novel insights into the roles of families and peers as influential socializing agents during the negotiation of ethnic and national identities among immigrant youth