Early predictive response to multi-tyrosine kinase inhibitors in advanced refractory radioactive-iodine differentiated thyroid cancer: A new challenge for [18 f]fdg pet/ct

Differentiated thyroid cancer (DTC) represents the most common thyroid cancer histotype. Generally, it exhibits a good prognosis after conventional treatments; nevertheless, about 20% of patients can develop a local recurrence and/or distant metastasis. In one-third of advanced DTC, the metastatic lesions lose the ability to take up iodine and become radioactive iodine-refractory (RAI-R) DTC. In this set of patients, the possibility to perform localized treatments should always be taken into consideration before the initiation of systemic therapy. In the last decade, some multi-tyrosine kinase inhibitor (MKI) drugs were approved for advanced DTC, impacting on patient’s survival rate, but at the same time, these therapies have been associated with several adverse events. In this clinical context, the role of 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography/computed tomography ([18 F]FDG PET/CT) in the early treatment response to these innovative therapies was investigated, in order to assess the potentiality of this diagnostic tool in the early recognition of non-responders, avoiding unnecessary therapy. Herein, we aimed to present a critical overview about the reliability of [18 F]FDG PET/CT in the early predictive response to MKIs in advanced differentiated thyroid cancer

Seismic retrofit of reinforced concrete frames by direct loss-based design

This paper introduces a procedure for the retrofit design of reinforced concrete (RC) frame buildings to achieve the desired target level of earthquake-induced loss for a given seismic hazard profile. The methodology is "direct" because the loss target is specified in the first step of the procedure, and, in principle, no design iterations are required. The target loss level is defined based on designer/client preferences and/or external constraints (e.g., foundation capacity). The proposed procedure relies on a simplified loss assessment enabled by a surrogate model defining the probability distribution of the seismic deformation demands of single degree of freedom (SDoF) systems given different ground-motion intensity levels. Combined with a hazard curve and a building-level damage-to-loss model, such a surrogate model is used to map candidate SDoF force-displacement curves to their earthquake-induced loss by assuming a given retrofit strategy. In this case, the considered retrofit strategy involves changing the frame's local hierarchy of strength to ensure a global plastic structure mechanism. Under such assumptions, a designer can select a design force-displacement curve among those that comply with the chosen loss target. The detailing of the retrofitted frame is carried out according to the direct displacement-based design principles and the Simplified Lateral Mechanism Analysis (SLaMA). The procedure is applied to an under-designed RC frame building retrofitted with concrete jacketing. A benchmark loss estimate is calculated using non-linear time-history analyses for loss assessment purposes. The proposed procedure shows satisfactory compliance with the benchmark loss, emphasising the procedure's effectiveness in practice

Gaussian process regression-based surrogate modelling for direct loss-based seismic design of low-rise base-isolated structures

Seismic base isolation has gained popularity in the last decades. As a result, many structures are now equipped with base isolation systems to offer enhanced seismic performance and meet the needs of risk-aware stakeholders. However, a robust performance-based seismic design of these types of structures is generally not carried out due to the iterative nature of common design approaches and the time/computational resources required for such iterations, which are incompatible with the preliminary design phase. Indeed, seismic risk/loss is often just assessed at the end of the design process as a final verification step. This paper offers an overview of a simplified methodology for the seismic design of low-rise structures equipped with a base isolation system to achieve a predefined level of earthquake-induced economic loss while complying with a predefined minimum level of structural reliability. The main advantage of the proposed methodology is that it requires no design iterations. The procedure is enabled by Gaussian-process-regression-based surrogate probabilistic seismic demand modelling of equivalent single degree of freedom systems (i.e., the probability distribution of peak horizontal displacements and accelerations on top of the isolation layer conditional on different ground-motion intensity levels). Combined with simplified loss models for the base isolation system and the structural and non-structural components of the superstructure, this approach allows mapping a range of structural configurations to their resulting seismic loss. A designer can then select one of the identified combinations of the strength of the superstructure and properties of the isolation system conforming with the loss target, and reliability requirements, and consequently detail the superstructure and isolation system accordingly. This paper introduces the implemented surrogate probabilistic seismic demand models and provides an overview of a tentative Direct Loss-based Design procedure for low-rise base-isolated structures

Heterogeneous effects of spinoff foundations on the means of technology transfer: the role of past academic-industry collaborations

Focusing on the Italian population of academic entrepreneurs, we analyze the effect of establishing a spinoff firm on researchers' attitudes towards carrying out other activities in collaboration with firms, namely, co-publishing and co-patenting. We investigate the heterogeneity in this effect in terms of existing collaborations with firms in the pre-spinoff period. Using a counterfactual analysis on subgroups, we verify that academic entrepreneurs with previous publications with firms diminish their co-publishing and increase their co-patenting after founding a spinoff. Conversely, academic entrepreneurs who had no previous publications with firms increase their co-publishing and decrease their co-patenting. We maintain that such results are related to academics' learning processes connected with their previous technology transfer activities. The policy implications are related to technology transfer aims and contradict the idea that promoting spinoffs is an appropriate "one-size-fits-all" initiative

Linfoma malt primario de la lengua

Los linfomas derivados de los tejidos linfoides asociados a las mucosas (MALT) primarios de la lengua son infrecuentes. Se documenta el caso de una paciente de 80 años de edad, con un tumor en el dorso de la lengua filiado histológicamente como linfoma extranodal de células B. Se sugiere como posible origen del linfoma un proceso reactivo de origen desconocido, al presentar las glándulas salivales menores adyacentes al tumor un cuadro compatible con una sialadenitis mioepitelial.Primitive malignant lymphoma mucosa associated lymphoid tissue (MALT) on the tongue are rare entities. We report here a case of an old woman (80 years old) with a tumor in the dorsum of the tongue, which was histologically diagnosed as an extra-nodal marginal B cell lymphoma. An inflammatory reaction resembling myoepithelial sialoadenitis was observed in the minor salivary glands adjacent at the tumour, suggesting a possible derivation of the lymphoma from a previous reactive process of unknown origin

Synchronous bilateral Warthin's tumours of the parotid glands: a case report

Warthin's tumour is the most frequent monomorphic adenoma of the major salivary glands, representing about 2-15% of all parotid tumours. Most of the multifocal Warthin's tumours are unilateral, whereas bilateral Warthin's tumours are far less common; bilateral Warthin's tumours are metachronous with few synchronous cases having been described in the literature. The Authors present an interesting case of simultaneously occurring bilateral Warthin's tumours growing in the parotid glands

Investigating the linkages between industrial policies and M&A dynamics: Evidence from China

Mergers and acquisitions (M&As hereafter) have been widely examined in the economic and business literature under many perspectives. However, the industry-level view, specifically the relation between industrial policies and M&A waves at the sectoral level, has remained rather unexplored. This article contributes to fill this gap by empirically investigating the relation between selective industrial policies and M&A waves at the industry level in China. Referring to the four Five Year Plans covering the period 1996-2015, we explore whether being identified as an emerging sector in these plans generates positive or negative changes in the number of M&As. We reiterate the analysis according to the different types of M&As (vertical, horizontal or conglomerate) and the different natures of the acquirer (SOEs or private). Our results suggest that policies can differentially affect M&A waves according to the type of M&A. Moreover, while private firms are more responsive to both horizontal and vertical integration in emerging sectors, SOEs are more prone to engage in vertical M&As. We discuss the possible rationales behind the different behaviors. We also draw general policy implications on strategic industrial policy and market restructuring

The role of 18F-FDG PET/CT in endometrial adenocarcinoma: a review of the literature and recent advances

Purpose: To provide a substantial coverage on the role of 18F-FDG PET/CT in endometrial cancer (EC), and identify the key issues which make its use recommended with both low level of evidence and low strength of recommendation in accordance with the last consensus conference. Methods: A comprehensive literature computer search was performed on PubMed/MEDLINE and Cochrane Library databases up to June 2020. Included studies had to focus on 18F-FDG PET/CT in EC, with regard to staging, follow-up and prognostic value. Review guidelines, systematic review, meta-analyses and original papers were included. Results: The 18F-FDG PET/CT is affected by suboptimal soft tissue differentiation, with sensitivity and specificity in tumor staging ranged from 77 to 85% and 79 to 96%. The sensitivity and the specificity of 18F-FDG PET/CT performed at staging for lymph node metastases ranged from 63 to 73% and 96 to 97%. For distant metastases, sensitivity and specificity of 18F-FDG PET/CT performed at staging ranged from 63 to 80% and 93 to 96%. After treatment, better performance emerged for EC recurrent with sensitivity ranged from 92 to 98% and specificity ranged from 89 to 94%. Maximum standardized uptake value (SUVmax) and metabolic volumetric parameters, such as total lesion glycolysis (TLG) and metabolic tumor volume (MTV), resulted to be significantly related to prognosis. Conclusion: Despite evidence-based data about the diagnostic performance are increasing, the low sensitivity represents the main limitation of 18F-FDG PET/CT imaging utilization for the detection of primary tumor and lymph node metastases. Better performances were observed for distant metastasis and EC recurrence. Further randomized prospective studies are needed to increase both the low level of evidence and low strength of recommendation for using 18F-FDG PET/CT in EC. Promising results emerged from PET/MRI

ENDOCANNABINOIDS CB1 AND CB2: A POSSIBLE ROLE IN ORAL SQUAMOUS CELL CARCINOMA PATHOGENESIS

Aim. Cancer of the oral cavity is the eighth most common malignancy in the world. The disease is diagnosed after a considerable delay and predict the individual progression is difficult. The improvements of the therapy did not increased the rate of survival at 5 years, that is still about 50%. The identification of the possible markers that indicates the progression of the tumor is therefore necessary. Endocannabinoids may play an important role in the process of carcinogenesis in the oral mucosa. They are able to bind and activate specific membrane receptors coupled to G proteins, cannabinoid receptors CB1 and CB2. The purpose of this study is to evaluate the expression of CB1 and CB2 receptors in the development of oral cancer through the immunohistochemical study on samples of OSCC. Materials and methods. We selected 44 cases of patients with the primary tumor in the oral cavity. The stage of the tumor was classified according to the TNM system. The tumors grading was divided into I, II and III grade. The paraffin sections were analyzed by immunohistochemistry. The assessment of the immunoreactivity for CB1 and CB2 receptors was weak or strong. For quantitative analysis the expression of CB1 and CB2 receptors was evaluated in percentage with scale of values ??ranging from 0 to 100%. Results. The immunohistochemical examination of the samples analyzed showed the absence of expression of CB1 and CB2 receptors in normal mucosa, while peritumoral mucosa showed a weak expression in the vicinity of cancer and tumor mucosa showed an overexpression of receptors. Furthermore, the intensity of staining increased with the increase of the grading. It can be concluded that the strong immunoreactivity of CB1 and CB2 receptors is related to aggressive behavior of oral carcinoma. Conclusions. The analysis of endocannabinoids and their receptors on tissue biopsies taken from carcinoma of the oral cavity may therefore indicate future therapeutic targets and new prognostic biomarkers in these patients, especially in the early stages of the disease. The ultimate goal of this work is to indicate the possible role of CB1 and CB2 receptors such as tumor biomarker that may help in the early diagnosis of oral cancer and therefore contribute to reduce drastically the mortality of this disease