Data Needs of Social Service Agencies: A Case Study of Fort Worth, Texas

There is increasing need for social service agencies and organizations to allocate resources and to plan based on objective needs assessment. This requires greater access and use of data sources. The dual objectives of this paper are to describe and analyze the increased need for data use by social welfare agencies and to present the findings of a data needs assessment study of such organizations in Fort Worth, Texas. The results of this study were used in the planning and development of a series of free data use and data use-applications workshops for social service agency representatives and in the writing of a detailed Resource Manual for agency data users

Preference-for-Solitude and Adjustment Difficulties in Early and Late Adolescence

Social withdrawal has been associated with adjustment difficulties across development. Although much is known about shyness, little is known about preference-for-solitude; even less is known about its relations with adjustment across different periods of adolescence. We examined whether preference-for-solitude might be differentially associated with adjustment difficulties in early and late adolescence. Self- and parent-reports of withdrawal motivations and adjustment were collected from 234 eighth graders (113 boys; M age = 13.43) and 204 twelfth graders (91 boys; M age = 17.25). Results from structural equation modeling demonstrated that above and beyond the effects of shyness, preference-for-solitude was more strongly associated with adjustment difficulties in 8th grade than in 12th grade. Preference-for-solitude was associated with greater anxiety/depression, emotion dysregulation, and lower self-esteem in 8th grade; these relations were not found in 12th grade. Although preference-for-solitude was associated with lower social competence in both 8th and 12th grades, this relation was significantly stronger in 8th grade than in 12th grade. Findings suggest preference-for-solitude has closer ties to maladjustment in early adolescence than in late adolescence. Interventions targeting preferred-solitary youth in early adolescence may be particularly fruitfu

The Role of Vaccination, Antiorthopoxvirus Drug, and Social Cooperativity in a Mathematical Model of Smallpox Control

Considerable effort has gone into making mathematical and computer models of smallpox spread and control measures, typically consisting of vaccination and quarantine. The orally available antiorthopoxvirus drug tecovirimat has recently completed Phase 2 clinical trials and shows promise as a smallpox control agent. We constructed 2 computer simulations to explore the use of tecovirimat in combination with vaccination and social cooperativity to control an outbreak. Two scenarios were considered: (1) a homogenously mixed, deterministic simulation of a single metropolitan area; and (2) a stochastic network of the 50 largest US metropolitan areas connected by commercial air traffic. Metropolitan-level mass vaccination coupled with drug treatment for all individuals who develop a fever considerably outperforms treating only those who develop smallpox's distinctive rash. Incorporating mass chemoprophylaxis represents another large improvement. More aggressive responses are more robust to low cooperation of the population with public health efforts and to faster disease spread. However, even with the most aggressive public health intervention, an attack that initially infects hundreds or thousands of individuals will need to be fought in multiple cities across the country.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140318/1/bsp.2012.0037.pd

The Relationship between Postural Control and Motor Proficiency in Children with Prader-Willi Syndrome and with Obesity

Prader-Willi Syndrome (PWS) is a rare neurodevelopmental genetic disorder that can lead to obesity. Children with PWS exhibit poor motor skills and poor postural control. Postural control is defined as the ability to regulate sensory information to maintain a controlled, upright posture. Underdeveloped vestibular and proprioceptive systems, shown in PWS, may interfere with maintaining posture and performing fundamental skills that require effective sensorimotor integration. Obesity (OB) can also be negative to postural control and motor skill development. PURPOSE: This study determined the relationship between postural control and motor proficiency in children with PWS and those with OB but without PWS. METHODS: Participants were 18 children with PWS (male=10, female=8; 9.9 ± 1.1 years old) and 51 children with OB (male= 25, female= 26; 9.11 ± 1.13 years old). Postural control was determined through the Sensory Organization Test (SOT) and motor proficiency was determined using the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition (BOT2). Three subtests from the BOT2 were used for the analysis (bilateral coordination, balance and running speed & agility) as it was speculated performance in these skills is related to postural control. Independent T-tests were used to compare postural control and motor proficiency between the groups. Pearson product correlations evaluated the associations between postural control and motor proficiency skills with a pRESULTS: Children with PWS showed lower postural control, bilateral coordination, static balance and running speed & agility than those with OB (p\u3c .001 for all). In children with PWS postural control was positively associated with bilateral coordination (r=.704), static balance (r=.665), and running speed and agility (r=.633). In those with OB postural control was associated only with running speed & agility (r=.305). CONCLUSION: In PWS postural control was positively associated with better performance in motor skills requiring static and or dynamic balance. In children with OB but without diagnosed neurodevelopmental issues only a weak association was shown. In PWS, targeting sensory motor integration skills affecting postural control may improve overall motor proficiency in this population

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.

Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual phosphorylation events within the multisite phosphorylation process have never been thoroughly studied. In Saccharomyces cerevisiae, the initiation of S phase is thought to be governed by complexes of Cdk1 and Cln cyclins that phosphorylate six or more sites on the Clb5-Cdk1 inhibitor Sic1, directing it to SCF-mediated destruction. The resulting Sic1-free Clb5-Cdk1 complex triggers S phase. Here, we demonstrate that Sic1 destruction depends on a more complex process in which both Cln2-Cdk1 and Clb5-Cdk1 act in processive multiphosphorylation cascades leading to the phosphorylation of a small number of specific phosphodegrons. The routes of these phosphorylation cascades are shaped by precisely oriented docking interactions mediated by cyclin-specific docking motifs in Sic1 and by Cks1, the phospho-adaptor subunit of Cdk1. Our results indicate that Clb5-Cdk1-dependent phosphorylation generates positive feedback that is required for switch-like Sic1 destruction. Our evidence for a docking network within clusters of phosphorylation sites uncovers a new level of complexity in Cdk1-dependent regulation of cell cycle transitions, and has general implications for the regulation of cellular processes by multisite phosphorylation

Evidence for Cosmic Acceleration is Robust to Observed Correlations Between Type Ia Supernova Luminosity and Stellar Age

Type Ia Supernovae (SNe Ia) are powerful standardizable candles for constraining cosmological models and provided the first evidence of the accelerated expansion of the universe. Their precision derives from empirical correlations, now measured from $>1000$ SNe Ia, between their luminosities, light-curve shapes, colors and most recently with the stellar mass of their host galaxy. As mass correlates with other galaxy properties, alternative parameters have been investigated to improve SN Ia standardization though none have been shown to significantly alter the determination of cosmological parameters. We re-examine a recent claim, based on 34 SN Ia in nearby passive host galaxies, of a 0.05 mag/Gyr dependence of standardized SN Ia luminosity on host age which if extrapolated to higher redshifts, would be a bias up to 0.25 mag, challenging the inference of dark energy. We reanalyze this sample of hosts using both the original method and a Bayesian hierarchical model and find after a fuller accounting of the uncertainties the significance of a dependence on age to be $\leq2\sigma$ and $\sim1\sigma$ after the removal of a single poorly-sampled SN Ia. To test the claim that a trend seen in old stellar populations can be applied to younger ages, we extend our analysis to a larger sample which includes young hosts. We find the residual dependence of host age (after all standardization typically employed for cosmological measurements) to be consistent with zero for 254 SNe Ia from the Pantheon sample, ruling out the large but low significance trend seen in passive hosts.Comment: 9 pages, 3 figures, 3 tables. Accepted for publication in ApJ

Collateral Estoppel

The doctrine of collateral estoppel involves the use of an old judgment in a new action to prevent the relitigation of issues resolved by that old judgment. At common law, use of the doctrine required that the party using collateral estoppel and the party against whom it was used be the same as the parties to the prior judgment. This common law requirement of mutuality has been relaxed and since the United States Supreme Court\u27s 1979 decision in ParklaneHoisery Co. v. Shore, the strict common law requirement of mutuality has all but completely vanished. In Parklane the Court sanctioned the use of collateral estoppel by a plaintiff who was a stranger to the original suit against a defendant who was party to that suit. The courts\u27 search for fair results and judicial economy in the application of the doctrine led to this application of the doctrine in circumstances in which the parties were not mutual. This note traces the un- steady course which the doctrine of collateral estoppel traveled before Parklane. The significance of the Court\u27s decision in Parklane is then analyzed. Finally, post-Parklane applications of collateral estoppel are discussed, including the effect of the use of collateral estoppel on the seventh amendment right to jury trial and its impact on substantive areas of law

Truth and Deception at the Rhetorical Structure Level

This paper furthers the development of methods to dis- tinguish truth from deception in textual data. We use rhetorical structure theory (RST) as the analytic framework to identify systematic differences between deceptive and truthful stories in terms of their coher- ence and structure. A sample of 36 elicited personal stories, self-ranked as truthful or deceptive, is manu- ally analyzed by assigning RST discourse relations among each story’s constituent parts. A vector space model (VSM) assesses each story’s position in multi- dimensional RST space with respect to its distance from truthful and deceptive centers as measures of the story’s level of deception and truthfulness. Ten human judges evaluate independently whether each story is deceptive and assign their confidence levels (360 evaluations total), producing measures of the expected human ability to recognize deception. As a robustness check, a test sample of 18 truthful stories (with 180 additional evaluations) is used to determine the reli- ability of our RST-VSM method in determining decep- tion. The contribution is in demonstration of the discourse structure analysis as a significant method for automated deception detection and an effective complement to lexicosemantic analysis. The potential is in developing novel discourse-based tools to alert information users to potential deception in computer- mediated texts