Preditores de mortalidade relacionados à flutter e fibrilação atrial: Descrição brasileira de 2018 a 2023

Atrial Fibrillation is the most prevalent cardiac arrhythmia, affecting 33 million people globally. In 2023, there were 3,046 new cases and a prevalence of 37.574 million, an increase of 33% in 20 years. This study aims to analyze the epidemiological profile of death rates from AF and flutter in Brazilian territory. This is an epidemiological, quantitative and retrospective study. Participants were individuals who died from flutter and atrial fibrillation in Brazil between 2018 and 2023. The data was organized by age group, sex, race, education and marital status. The analysis included 24,224 individuals, with the majority of deaths occurring in people aged 80 or over (52.15%). As for sex, 56.02% were women and 43.98% men. In terms of education, 24.05% had 1 to 3 years of study. The majority of participants were white (63.04%). As for marital status, 38.68% were widowed. Thus, the highest frequency of death among white females, aged over 80 years, widows, with between 1 and 3 years of schooling and residing in the Southeast region.A Fibrilação Atrial é a arritmia cardíaca mais prevalente, afetando 33 milhões de pessoas globalmente. Em 2023, ocorreram 3.046 novos casos e uma prevalência de 37.574 milhões, um aumento de 33% em 20 anos. Este estudo visa analisar o perfil epidemiológico das taxas de óbito por FA e flutter em território brasileiro. Trata-se de um estudo epidemiológico, quantitativo e retrospectivo. Os participantes foram indivíduos com óbito relacionado a flutter e fibrilação atrial no Brasil entre 2018 e 2023. Os dados foram organizados por faixa etária, sexo, raça, escolaridade e estado civil. A análise incluiu 24.224 indivíduos, com a maioria dos óbitos ocorridos em pessoas com 80 anos ou mais (52,15%). Quanto ao sexo, 56,02% eram mulheres e 43,98% homens. Em termos de escolaridade, 24,05% tinham de 1 a 3 anos de estudo. A maioria dos participantes era branca (63,04%). Quanto ao estado civil, 38,68% eram viúvos. Assim, a maior frequência de morte entre indivíduos do sexo feminino de cor branca, com idade superior a 80 anos, viúvas, entre 1 a 3 anos de escolaridade e residentes na região Sudeste

Análise descritiva das internações hospitalares por traumatismo do olho e da órbita ocular em caráter de urgência no Brasil

Head and facial injuries account for 50% of trauma deaths, with common causes being motorcycle accidents and violence. Orbital fractures are complex due to their three-dimensional anatomy and the main ophthalmological manifestations include low visual acuity, hyphema and ophthalmoplegia, resulting from edema, hemorrhage and various injuries. This work aims to analyze the epidemiological profile of hospital morbidity due to trauma to the eye and ocular orbit as an emergency in Brazil. This quantitative and retrospective ecological study used data from SIH/SUS in DATASUS, collected in June 2024. Variables included region, age group, sex and color/race. During the period analyzed, 13,230 hospitalizations were recorded. The distribution by age group shows that the majority of hospitalizations occurred between 20 and 49 years old (49.61%). Regarding color/race, 38.84% of patients were mixed race, 32.31% white, 4.43% black, 1.18% yellow, and 0.14% indigenous. The highest frequency of hospitalizations was among male individuals, mixed race, aged between 30 and 39 years old, residing in the Southeast region.Lesões na cabeça e face representam 50% das mortes por trauma, com causas comuns sendo acidentes motociclísticos e violência. Fraturas orbitais são complexas devido à anatomia tridimensional e as principais manifestações oftalmológicas incluem baixa acuidade visual, hifema e oftalmoplegia, decorrentes de edemas, hemorragias e lesões diversas. Este trabalho visa analisar o perfil epidemiológico da morbidade hospitalar por traumatismo do olho e órbita ocular em caráter de urgência no Brasil. Este estudo ecológico quantitativo e retrospectivo utilizou dados do SIH/SUS no DATASUS, coletados em junho de 2024. As variáveis incluíram região, faixa etária, sexo e cor/raça. No período analisado, foram registradas 13.230 internações. A distribuição por faixa etária mostra que a maioria das internações ocorreu entre 20 e 49 anos (49,61%). Quanto à cor/raça, 38,84% dos pacientes eram pardos, 32,31% brancos, 4,43% pretos, 1,18% amarelos, e 0,14% indígenas. A maior frequência de internações foi entre indivíduos do sexo masculino, de cor parda, com idade entre 30 e 39 anos, residentes na região Sudeste. &nbsp

Sin / Sense

Sexto desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere «Purificación Escribano» de la Universitat Jaume

Síntesis enzimática de glicósidos de EGCG para potenciar sus propiedades bioactivas

1 p.Financiación: GLYSUS RTI2018-093683-Β-I00 (MCIU/AEI/FEDER) y RETOPROSOST2 S2018/EMT-4459 (Comunidad de Madrid).Peer reviewe

Glycosylation of epigallocatechin gallate by engineered glycoside hydrolases from Talaromyces amestolkiae: potential antiproliferative and neuroprotective effect of these molecules

16 p.-6 fig.-2 tab.Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed end up being hydrolyzed by these same enzymes. For this reason, mutagenic variants with null or drastically reduced hydrolytic activity have been developed, thus enhancing their synthetic ability. Two mutagenic variants, a glycosynthase engineered from a β-glucosidase (BGL-1-E521G) and a thioglycoligase from a β-xylosidase (BxTW1-E495A), both from the ascomycete Talaromyces amestolkiae, were used to synthesize three novel epigallocatechin gallate (EGCG) glycosides. EGCG is a phenolic compound from green tea known for its antioxidant effects and therapeutic benefits, whose glycosylation could increase its bioavailability and improve its bioactive properties. The glycosynthase BGL-1-E521G produced a β-glucoside and a β-sophoroside of EGCG, while the thioglycoligase BxTW1-E495A formed the β-xyloside of EGCG. Glycosylation occurred in the 5″ and 4″ positions of EGCG, respectively. In this work, the reaction conditions for glycosides’ production were optimized, achieving around 90% conversion of EGCG with BGL-1-E521G and 60% with BxTW1-E495A. The glycosylation of EGCG caused a slight loss of its antioxidant capacity but notably increased its solubility (between 23 and 44 times) and, in the case of glucoside, also improved its thermal stability. All three glycosides showed better antiproliferative properties on breast adenocarcinoma cell line MDA-MB-231 than EGCG, and the glucosylated and sophorylated derivatives induced higher neuroprotection, increasing the viability of SH-S5Y5 neurons exposed to okadaic acid.This research was funded by the MICIU/AEI/FEDER (RTI2018-093683-B-I00), Comunidad de Madrid (RETOPROSOST-2-CM P2018/EMT-4459), CSIC Interdisciplinary Thematic Platform (PTI+) NEURO-AGING+ (PTI-NEURO-AGING+), and PI20/00590 Instituto de Salud Carlos III. The authors acknowledge BioSFerA (RIA 884208) and IBISBA1.0 (H2020 730976) projects for the supporPeer reviewe

Excerpta Botanica Pharmaceutica

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Carles Benedí i Joan SimonEl disseny de l’activitat ha estat a càrrec del Grup d’Innovació Docent de Botànica Aplicada a les Ciències Farmacèutiques (GIBAF), i s’emmarca en el Projecte d’Innovació Docent «Excerpta Botanica Pharmaceutica: creació de recursos docents en obert pels propis estudiants com a nova estratègia d’innovació docent» (codi 2014PID-UB/010) del Programa de Millora i Innovació Docent (PMID) de la Universitat de Barcelona.Amb el nom genèric d’Excerpta Botanica Pharmaceutica (extracte de Botànica Farmacèutica), agrupem els treballs (guies d’estudi) que han redactat de forma tutorizada els estudiants del grup T3 de l’assignatura Botànica Farmacèutica (curs 2013-14). Els objectius específics han estat: aprendre a utilitzar correctament la nomenclatura botànica en la denominació de les espècies, saber redactar ordenadament la descripció d’una espècie amb la terminologia botànica adequada, cercar utilitzar i integrar la informació botànica de referència i proposar-ne d’addicional comentades i fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. Els objectius transversals han estat: estimular el compromís ètic (imatges incloses de llicència lliure), desenvolupar una capacitat de síntesi escrita i de tenir visions globals integradores (la monografia aportada), mantenir una pulcritud en el treball i compromís per la feina ben feta (responsabilitat en el futur material d'ús docent per als seus companys, dipòsit digital UB) i fomentar la apacitat autocrítica (la seva autoavaluació)