Overview of escalator applications in rail transit

The difference in operating environment and in construction between escalators in transit and nontransit use, the impact of recent escalator innovations, and areas which could benefit from urban mass transportation administration sponsored research and development are determined. Several factors causing a more severe transit escalator operating environment are identified. There are no significant design differences between transit and nontransit escalators. Recent innovations that have affected performance and cost include outdoor escalators, extra flat steps at both landings, and modular escalators. Data were collected by interviews at transit agencies. Long term, unscheduled, escalator maintenance records were available for analysis from one property. A description of escalator operating principles is provided. Transit represents less than 5% of the U.S. escalator market. Transit agencies have limited leverage on escalator industry practices. A substantial impact on transit escalator cost and performance can be achieved by research identifying when and how to apply and specify several of the more recent innovations. Purchase of escalators under long term (25 year) maintenance contracts is one method that has been used to promote escalators manufactured for minimum life cycle cost

HST Observations of the Central-Cusp Globular Cluster NGC 6752. The Effect of Binary Stars on the Luminosity Function in the Core

We consider the effect of binary stars on the main-sequence luminosity functions observed in the core of globular clusters, with specific reference to NGC 6752. We find that mass segregation results in an increased binary fraction at fainter magnitudes along the main-sequence. If this effect is not taken into account when analyzing luminosity functions, erroneous conclusions can be drawn regarding the distribution of single stars, and the dynamical state of the cluster. In the core of NGC 6752, our HST data reveal a flat luminosity function, in agreement with previous results. However, when we correct for the increasing binary fraction at faint magnitudes, the LF begins to fall immediately below the turn-off. This effect appears to be confined to the inner core radius of the cluster.Comment: 10 pages, 3 figures Accepted to ApJ Lett Vol 513 Number

Activation of G protein-coupled receptors entails cysteine modulation of agonist binding

The increase of the affinity of agonists with an increase in pH and experiments using thiol-specific reagents indicate that G protein-coupled receptors contain an ionizable cysteine residue at the ligand binding site. Since treatment of receptors with reducing agents produces functional activation and potentiates agonist stimulation, it is likely that this free sulfhydryl modulates receptor activation. We have derived a two-state acid-base model for cysteine modulation of ligand binding which leads to a description of ligand efficacy. We have shown that pH-dependent binding of agonists is closely correlated with measurements of ligand efficacy at the 5-HT2A receptor. In general, efficacy is determined by the preference of a ligand for the base of the receptor. Efficacy may also be described in thermodynamic terms as the coupling free energy involving a ligand and the acid and base states of the receptor. Molecular modeling of the third transmembrane domain of the 5-HT2A receptor, which contains a conserved cysteine, shows that efficacy is determined by the difference between the electrostatic interaction energies of a ligand with the acid and base forms of the receptor model. The difference in interaction energy between the two forms of cysteine makes the largest contribution to this electrostatic interaction energy difference. Therefore, the cysteine makes the largest contribution to ligand efficacy. Using this approach, we can distinquish between the efficacies of agonists with varying molecular structures and account for the differences between the properties of agonists and antagonists

Methodology for urban rail and construction technology research and development planning

A series of transit system visits, organized by the American Public Transit Association (APTA), was conducted in which the system operators identified the most pressing development needs. These varied by property and were reformulated into a series of potential projects. To assist in the evaluation, a data base useful for estimating the present capital and operating costs of various transit system elements was generated from published data. An evaluation model was developed which considered the rate of deployment of the research and development project, potential benefits, development time and cost. An outline of an evaluation methodology that considered benefits other than capital and operating cost savings was also presented. During the course of the study, five candidate projects were selected for detailed investigation; (1) air comfort systems; (2) solid state auxiliary power conditioners; (3) door systems; (4) escalators; and (5) fare collection systems. Application of the evaluation model to these five examples showed the usefulness of modeling deployment rates and indicated a need to increase the scope of the model to quantitatively consider reliability impacts

Continuous Sculpting: Persistent Swarm Shape Formation Adaptable to Local Environmental Changes

Despite their growing popularity, swarms of robots remain limited by the operating time of each individual. We present algorithms which allow a human to sculpt a swarm of robots into a shape that persists in space perpetually, independent of onboard energy constraints such as batteries. Robots generate a path through a shape such that robots cycle in and out of the shape. Robots inside the shape react to human initiated changes and adapt the path through the shape accordingly. Robots outside the shape recharge and return to the shape so that the shape can persist indefinitely. The presented algorithms communicate shape changes throughout the swarm using message passing and robot motion. These algorithms enable the swarm to persist through any arbitrary changes to the shape. We describe these algorithms in detail and present their performance in simulation and on a swarm of mobile robots. The result is a swarm behavior more suitable for extended duration, dynamic shape-based tasks in applications such as agriculture and emergency response.Comment: 20 pages, 17 figure

When “embedded” means “stuck” : moderating effects of job embeddedness in adverse work environments

Job embeddedness is predominately assumed to benefit employees, work groups, and organizations (e.g., higher performance, social cohesion, and lower voluntary turnover). Challenging this assumption, we examined the potentially negative outcomes that may occur if employees are embedded in an adverse work environment - feeling “stuck”, yet unable to exit a negative situation. More specifically, we considered two factors representing adverse work conditions: abusive supervision and job insecurity. Drawing from conservation-of-resources theory, we hypothesized that job embeddedness would moderate the relationship between these conditions and outcomes of voluntary turnover, physical health, emotional exhaustion, and sleep quality/quantity, such that employees embedded in more adverse environments would be less likely to quit, but would experience more negative personal outcomes. Results from two independent samples, one in Japan (N=597) and one in the United States (N=283), provide support for the hypothesized pattern of interaction effects, thereby highlighting a largely neglected “dark side” of job embeddedness

Causal Consistency of Structural Equation Models

Complex systems can be modelled at various levels of detail. Ideally, causal models of the same system should be consistent with one another in the sense that they agree in their predictions of the effects of interventions. We formalise this notion of consistency in the case of Structural Equation Models (SEMs) by introducing exact transformations between SEMs. This provides a general language to consider, for instance, the different levels of description in the following three scenarios: (a) models with large numbers of variables versus models in which the `irrelevant' or unobservable variables have been marginalised out; (b) micro-level models versus macro-level models in which the macro-variables are aggregate features of the micro-variables; (c) dynamical time series models versus models of their stationary behaviour. Our analysis stresses the importance of well specified interventions in the causal modelling process and sheds light on the interpretation of cyclic SEMs.Comment: equal contribution between Rubenstein and Weichwald; accepted manuscrip

Optimization of a solution growth experiment for zero gravity and development of apparatus for a melt growth experiment Final report

Optimization for zero gravity experiment on solution growth of gallium arsenide and design of experiment package for melt growth of indium antimonide crystal

Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons

Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE). Dlx1/2(-/-) and Lhx6(-/-) mouse mutants, which exhibit MGE interneuron migration defects, have reduced expression of the gene encoding the alpha subunit of a soluble guanylate cyclase (Gucy1A3). Furthermore, Dlx1/2(-/-) mouse mutants have reduced expression of NO synthase 1 (NOS1). Gucy1A3(-/-) mice have a transient reduction in cortical interneuron number. Pharmacological inhibition of soluble guanylate cyclase and NOS activity rapidly induces neurite retraction of MGE cells in vitro and in slice culture and robustly inhibits cell migration from the MGE and caudal ganglionic eminence. We provide evidence that these cellular phenotypes are mediated by activation of the Rho signaling pathway and inhibition of myosin light chain phosphatase activity