Senderos de Agua. Proyecto de Gestión del Patrimonio Hidráulico de Torrijo de la Cañada.

Torrijo de la Cañada es un pequeño pueblo que se encuentra en la Comarca Comunidad de Calatayud. A pesar de tener una gran riqueza patrimonial y posibilidades de explotación turística, este pueblo no supera los 200 habitantes. Además de esta gran cantidad de bienes patrimoniales, Torrijo de la Cañada se sitúa en un punto estratégico en el Valle del río Manubles ya que es el único pueblo de la zona que queda dividido por el cauce del río. La presencia de este río ha determinado la forma de vivir de sus habitantes. El objetivo de este proyecto es poner en valor el agua como un elemento patrimonial fundamental. Torrijo de la Cañada cuenta con numerosos bienes hidráulicos como norias de sangre, molinos, acequias, azudes, etc. El proyecto que presentamos pretende poner en valor todos estos bienes vinculados con el uso del agua mediante la propuesta de cinco actividades. La actividad principal es la creación de un centro de interpretación del agua usando como infraestructura un antiguo molino.<br /

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele