Needle in the Cyberstack: Consumer Search For Information in the Web-Based Marketspace

With a few simple clicks, consumers can navigate the World Wide Web, move from site to site, access and examine vast amounts of information unconstrained by time and place which have traditionally restricted consumer behavior in the physical marketplace. At least, that is according to theory. Information search on the Internet should, therefore, increase since search costs are reduced. But empirical evidence seems to suggest otherwise. Why aren=t consumers searching for more information? Although the Internet reduces the cost of physical effort in moving from store to store, it may not reduce the cognitive cost of moving from site to site. Further, if consumers\u27 motivation to shop online is to reduce effort and save time, why should one expect consumers to search for more information even if the search costs are relatively lower

Behavioral Assumptions Underlying Business Models of Retail E-Commerce Ventures

This paper focuses on two research questions: (1) What assumptions regarding changes in online consumer behavior are implicit in the business models of retail ecommerce ventures? (2) Based on potential match between a business model’s assumptions and anticipated consumer response, what generalizations can be made about the potential success of retail e-commerce ventures? An interpretive framework that helps answer these questions is presented

A Note on Acceleration from Product Space Compactification

We study compactifications of Einstein gravity on product spaces in vacuum and their acceleration phases. Scalar potentials for the dimensionally reduced effective theory are found to be of exponential form and exact solutions are obtained for a class of product spaces. The inflation in our solutions is not sufficient for the early universe. We comment on the possibility of obtaining sufficient inflation by compactification in general.Comment: 19 pages, 6 figures, v2: further comments and references added, v3: typos fixe

Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

High level MYC expression is associated with almost all human cancers. JQ1, a chemical compound that inhibits MYC expression is therapeutically effective in preclinical animal models in midline carcinoma, and Burkitt’s lymphoma (BL). Here we show that JQ1 does not inhibit MYC expression to a similar extent in all tumor cells. The BL cells showed a ∼90% decrease in MYC transcription upon treatment with JQ1, however, no corresponding reduction was seen in several non-BL cells. Molecularly, these differences appear due to requirements of Brd4, the most active version of the Positive Transcription Elongation Factor B (P-TEFb) within the Super Elongation Complex (SEC), and transcription factors such as Gdown1, and MED26 and also other unknown cell specific factors. Our study demonstrates that the regulation of high levels of MYC expression in different cancer cells is driven by unique regulatory mechanisms and that such exclusive regulatory signatures in each cancer cells could be employed for targeted therapeutics

Hyperbolic Space Cosmologies

We present a systematic study of accelerating cosmologies obtained from M/string theory compactifications of hyperbolic spaces with time-varying volume. A set of vacuum solutions where the internal space is a product of hyperbolic manifolds is found to give qualitatively the same accelerating four-dimensional FLRW universe behavior as a single hyperbolic space. We also examine the possibility that our universe is a hyperbolic space and provide exact Milne type solutions, as well as intersecting S-brane solutions. When both the usual 4D spacetime and the m-dimensional internal space are hyperbolic, we find eternally accelerating cosmologies for $m\geq 7$, with and without form field backgrounds. In particular, the effective potential for a magnetic field background in the large 3 dimensions is positive definite with a local minimum and thus enhances the eternally accelerating expansion.Comment: 33 pages, 2 figures; v2 refs added; v3 minor change in text, JHEP versio

Rhamnose is superior to mannitol as a monosaccharide in the dual sugar absorption test: A prospective randomized study in children with treatment-naïve celiac disease

BACKGROUND AND AIM: We sought to correlate two different measures of gut permeability [lactulose:mannitol (L:M) and lactulose:rhamnose (L:R)] to the severity of duodenal histopathology in children with and without elevated antibodies to tissue transglutaminase (tTG). A secondary objective was to correlate gut permeability with celiac disease (CD) serology and indices of inflammation and bacterial product translocation. METHODS: We prospectively randomized children undergoing endoscopy with abnormal ( RESULTS: Of the 54 cases with positive celiac serology, 31 and 69% had modified Marsh 0/1 scores or ≥3a, respectively. Circulating tTG IgA correlated with the modified Marsh score ( CONCLUSIONS: L:R, but not L:M, is associated with modified Marsh scores in children undergoing small bowel biopsy for suspected CD. Despite increased intestinal permeability, we see scant evidence of systemic exposure to gut microbes in these children. Gut permeability testing with L:R may predict which patients with abnormal celiac serology will have biopsy evidence for celiac disease and reduce the proportion of such patients undergoing endoscopy whose Marsh scores are ≤1. M should not be used as a monosaccharide for permeability testing in children

The Discovery and Nature of Optical Transient CSS100217:102913+404220

We report on the discovery and observations of the extremely luminous optical transient CSS100217:102913+404220 (CSS100217 hereafter). Spectroscopic observations show this transient was coincident with a galaxy at redshift z=0.147, and reached an apparent magnitude of V ~ 16.3. After correcting for foreground Galactic extinction we determine the absolute magnitude to be M_V =-22.7 approximately 45 days after maximum light. Based on our unfiltered optical photometry the peak optical emission was L = 1.3 x 10^45 erg s^-1, and over a period of 287 rest-frame days had an integrated bolometric luminosity of 1.2 x 10^52 erg. Analysis of the pre-outburst SDSS spectrum of the source shows features consistent with a Narrow-line Seyfert1 (NLS1) galaxy. High-resolution HST and Keck followup observations show the event occurred within 150pc of nucleus of the galaxy, suggesting a possible link to the active nuclear region. However, the rapid outburst along with photometric and spectroscopic evolution are much more consistent with a luminous supernova. Line diagnostics suggest that the host galaxy is undergoing significant star formation. We use extensive follow-up of the event along with archival CSS and SDSS data to investigate the three most likely sources of such an event; 1) an extremely luminous supernova; 2) the tidal disruption of a star by the massive nuclear black hole; 3) variability of the central AGN. We find that CSS100217 was likely an extremely luminous type IIn supernova that occurred within range of the narrow-line region of an AGN. We discuss how similar events may have been missed in past supernova surveys because of confusion with AGN activity.Comment: submitted to Ap