Building a Spiking Neural Network Model of the Basal Ganglia on SpiNNaker

We present a biologically-inspired and scalable model of the Basal Ganglia (BG) simulated on the SpiNNaker machine, a biologically-inspired low-power hardware platform allowing parallel, asynchronous computing. Our BG model consists of six cell populations, where the neuro-computational unit is a conductance-based Izhikevich spiking neuron; the number of neurons in each population is proportional to that reported in anatomical literature. This model is treated as a single-channel of action-selection in the BG, and is scaled-up to three channels with lateral cross-channel connections. When tested with two competing inputs, this three-channel model demonstrates action-selection behaviour. The SpiNNaker-based model is mapped exactly on to SpineML running on a conventional computer; both model responses show functional and qualitative similarity, thus validating the usability of SpiNNaker for simulating biologically-plausible networks. Furthermore, the SpiNNaker-based model simulates in real time for time-steps 1 ms; power dissipated during model execution is & #x2248;1.8 W

On the α−\alpha-decay of deformed actinide nuclei

$\alpha-$decay through a deformed potential barrier produces significant mixing of angular momenta when mapped from the nuclear interior to the outside. Using experimental branching ratios and either semi-classical or coupled-channels transmission matrices, we have found that there is a set of internal amplitudes which are essentially constant for all even--even actinide nuclei. These same amplitudes also give good results for the known anisotropic $\alpha-$particle emission of the favored decays of odd nuclei in the same mass region. PACS numbers: 23.60.+e, 24.10.Eq, 27.90.+bComment: 5 pages, latex (revtex style), 2 embedded postscript figures uuencoded gz-compressed .tar file To appear in Physical Review Letter

Mobilized Peripheral Blood Stem Cells Versus Unstimulated Bone Marrow As a Graft Source for T-Cell-Replete Haploidentical Donor Transplantation Using Post-Transplant Cyclophosphamide.

Purpose T-cell-replete HLA-haploidentical donor hematopoietic transplantation using post-transplant cyclophosphamide was originally described using bone marrow (BM). With increasing use of mobilized peripheral blood (PB), we compared transplant outcomes after PB and BM transplants. Patients and Methods A total of 681 patients with hematologic malignancy who underwent transplantation in the United States between 2009 and 2014 received BM (n = 481) or PB (n = 190) grafts. Cox regression models were built to examine differences in transplant outcomes by graft type, adjusting for patient, disease, and transplant characteristics. Results Hematopoietic recovery was similar after transplantation of BM and PB (28-day neutrophil recovery, 88% v 93%, P = .07; 100-day platelet recovery, 88% v 85%, P = .33). Risks of grade 2 to 4 acute (hazard ratio [HR], 0.45; P \u3c .001) and chronic (HR, 0.35; P \u3c .001) graft-versus-host disease were lower with transplantation of BM compared with PB. There were no significant differences in overall survival by graft type (HR, 0.99; P = .98), with rates of 54% and 57% at 2 years after transplantation of BM and PB, respectively. There were no differences in nonrelapse mortality risks (HR, 0.92; P = .74) but relapse risks were higher after transplantation of BM (HR, 1.49; P = .009). Additional exploration confirmed that the higher relapse risks after transplantation of BM were limited to patients with leukemia (HR, 1.73; P = .002) and not lymphoma (HR, 0.87; P = .64). Conclusion PB and BM grafts are suitable for haploidentical transplantation with the post-transplant cyclophosphamide approach but with differing patterns of treatment failure. Although, to our knowledge, this is the most comprehensive comparison, these findings must be validated in a randomized prospective comparison with adequate follow-up

Improving catalyst activity in secondary amine catalysed transformations

The effect on catalyst performance of altering substituents at the 2-position of the Macmillan imidazolidinone has been examined. Condensation of L-phenylalanine N-methyl amide with acetophenone derivatives results in a series of imidazolidinones whose salts can be used to accelerate the Diels-Alder cycloaddition. Electron withdrawing groups significantly increases the overall rate of cycloaddition without compromise in selectivity. The most effective catalyst was shown to be efficient for a variety of substrates and the applicability of this catalyst to alternative secondary amine catalysed transformations is also discussed

Isomeric states in 253^{253}No

6 pagesInternational audienceIsomeric states in 253No have been investigated by conversion-electron and gamma-ray spectroscopy with the GABRIELA detection system. The 31 micro second isomer reported more than 30 years ago is found to decay to the ground state of 253No by the emission of a 167 keV M2 transition. The spin and parity of this low-lying isomeric state are established to be 5/2+. The presence of another longer-lived isomeric state is also discussed

Quantum Tunneling in Nuclear Fusion

Recent theoretical advances in the study of heavy ion fusion reactions below the Coulomb barrier are reviewed. Particular emphasis is given to new ways of analyzing data, such as studying barrier distributions; new approaches to channel coupling, such as the path integral and Green function formalisms; and alternative methods to describe nuclear structure effects, such as those using the Interacting Boson Model. The roles of nucleon transfer, asymmetry effects, higher-order couplings, and shape-phase transitions are elucidated. The current status of the fusion of unstable nuclei and very massive systems are briefly discussed.Comment: To appear in the January 1998 issue of Reviews of Modern Physics. 13 Figures (postscript file for Figure 6 is not available; a hard copy can be requested from the authors). Full text and figures are also available at http://nucth.physics.wisc.edu/preprints

Effects of finite width of excited states on heavy-ion sub-barrier fusion reactions

We discuss the effects of coupling of the relative motion to nuclear collective excitations which have a finite lifetime on heavy-ion fusion reactions at energies near and below the Coulomb barrier. Both spreading and escape widths are explicitly taken into account in the exit doorway model. The coupled-channels equations are numerically solved to show that the finite resonance width always hinders fusion cross sections at subbarrier energies irrespective of the relative importance between the spreading and the escape widths. We also show that the structure of fusion barrier distribution is smeared due to the spreading of the strength of the doorway state.Comment: 13 pages, 3 figures, Submitted to Physical Review

Possible Tomography of the Sun's Magnetic Field with Solar Neutrinos

The data from solar neutrino experiments together with standard solar model predictions are used in order to derive the possible profile of the magnetic field inside the Sun, assuming the existence of a sizeable neutrino magnetic moment and the resonant spin flavour mechanism. The procedure is based on the relationship between resonance location and the energy dependent neutrino suppression, so that a large neutrino suppression at a given energy is taken to be connected to a large magnetic field in a given region of the Sun. In this way it is found that the solar field must undergo a very sharp increase by a factor of at least 6 - 7 over a distance no longer than 7 - 10% of the solar radius, decreasing gradually towards the surface. The range in which this sharp increase occurs is likely to be the bottom of the convective zone. There are also indications in favour of the downward slope being stronger at the start and more moderate on approaching the solar surface. Typical ranges for the magnetic moment are from a few times 10^{-13}\mu_B to its laboratory upper bounds while the mass square difference between neutrino flavours is of order (0.6-1.9) x 10^{-8}eV^2.Comment: Several minor corrections performed, sunspot anticorrelation discussed, references added, 29 pages including 8 figures in PostScrip

Coupled-channels analysis of the 16^{{\bf 16}}O+208^{{\bf 208}}Pb fusion barrier distribution

Analyses using simplified coupled-channels models have been unable to describe the shape of the previously measured fusion barrier distribution for the doubly magic $^{16}$O+$^{208}$Pb system. This problem was investigated by re-measuring the fission excitation function for $^{16}$O+$^{208}$Pb with improved accuracy and performing more exact coupled-channels calculations, avoiding the constant-coupling and first-order coupling approximations often used in simplified analyses. Couplings to the single- and 2-phonon states of $^{208}$Pb, correctly taking into account the excitation energy and the phonon character of these states, particle transfers, and the effects of varying the diffuseness of the nuclear potential, were all explored. However, in contrast to other recent analyses of precise fusion data, no satisfactory simultaneous description of the shape of the experimental barrier distribution and the fusion cross-sections for $^{16}$O+$^{208}$Pb was obtained.Comment: RevTex, 29 pages, 7 postscript figures, to appear in PR

Complex circular subsidence structures in tephra deposited on large blocks of ice: Varða tuff cone, Öræfajökull, Iceland

Several broadly circular structures up to 16 m in diameter, into which higher strata have sagged and locally collapsed, are present in a tephra outcrop on southwest Öræfajökull, southern Iceland. The tephra was sourced in a nearby basaltic tuff cone at Varða. The structures have not previously been described in tuff cones, and they probably formed by the melting out of large buried blocks of ice emplaced during a preceding jökulhlaup that may have been triggered by a subglacial eruption within the Öræfajökull ice cap. They are named ice-melt subsidence structures, and they are analogous to kettle holes that are commonly found in proglacial sandurs and some lahars sourced in ice-clad volcanoes. The internal structure is better exposed in the Varða examples because of an absence of fluvial infilling and reworking, and erosion of the outcrop to reveal the deeper geometry. The ice-melt subsidence structures at Varða are a proxy for buried ice. They are the only known evidence for a subglacial eruption and associated jökulhlaup that created the ice blocks. The recognition of such structures elsewhere will be useful in reconstructing more complete regional volcanic histories as well as for identifying ice-proximal settings during palaeoenvironmental investigations