Biotransformation of ent-beyerenes with mucor plumbeus

Indexación: Web of Science; Scielo.ABSTRACT The microbiological transformation of ent-beyer-15-en-18-ol 1 and ent-beyer-15-en-19-ol 2, using Mucorplumbeus, resulted in hydroxylated products. After nine days of incubation, 15β,16β-epoxide-ent-beyeran-7β,18-diol 3, ent-beyer-15-en-7p,19-diol 4 and 15β,16β-epoxide-ent-beyeran-7β,19-diol 5 were isolated. The metabolites were identified by spectroscopic methods. Key Words:http://ref.scielo.org/47kx2

NEW BUTYROLACTONE FROM A MARINE-DERIVED FUNGUS ASPERGILLUS SP

Indexación: Web of Science; ScieloFour compounds that belong to two structure types, namely dibenzylbutyrolactone and sesterterpenoids, were obtained from the extract of the strain Aspergillus sp. (2P-22), isolated from a marine sponge, Cliona chilensis. Among them, compound 1 was identified as new, namely butylrolactone-VI. The structures of these compounds were characterized on the basis of spectroscopic data. Biological activities of these fungal metabolites, are described.http://ref.scielo.org/kbf7v

Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines

The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents

A novel metabolite from the Chilean mollusk Siphonaria lessoni

A new and two previously known metabolites possessing a polypropionate carbon skeleton have been isolated from the marine gastropod mollusk Siphonaria lessoni, collected at Chilean coasts. Their structures have been determined by spectroscopical methods

Variations in the halogenated monoterpene metabolites of plocamium cartilagineum of the chilean coast

Examination of six samples of the red alga P. cartilagineum collected along 1600 km of Central Chilean coast yielded a number of polyhalogenated monocyclic monoterpenes. Acyclic compounds were not found. Two common compounds for all samples have been found. By means of their chemical composition, the samples can be separated into two main groups. © 1986

Halogenated sesquiterpenes pacifenol and pacifenol derivatives on the aphid Schizaphis graminum

Pacifenol, a halogenated sesquiterpene was isolated from Laurencia claviformis. The effects of pacifenol and two derivatives on survival and feeding behaviour of the aphid Schizaphis graminum were studied. Toxicity of pacifenol was lower than the other compounds, and the dibromo derivative was more toxic than pacifidiene. At concentrations higher than 250 and 750 ppm, respectively, both compounds acted as antifeedants on aphids. © 1993

Insecticide and acaricide activities of polyhalogenated monoterpenes from chilean Plocamium cartilagineum

Four new alicyclic monoterpenes based on the 1-(2-chlorovinyl)-2,4,5-trichloro-1,5-dimethylcyclohexane skeleton were isolated from Plocamium cartilagineum from the Chilean coast, together with four known cyclic monoterpenes. The structure of the new compounds were determined by comparison of the spectral data with those of known compounds. The insecticide/acaricide and fungicide activities of some of the isolated monoterpenes were determined. © 1991

Secondary metabolites from marine Penicillium brevicompactum

6 pages, 2 tables.In a screening of Basidiomycete cultures isolated from marine invertebrates collected along the Chilean coastline for the production of antibiotics we identified a Penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four known metabolites. Their structures were elucidated by spectroscopic methods.This research was supported by Fondecyt, Chile. Project Nº 1040895Peer reviewe

Two chemical types of the red alga Plocamium cartilagineum from Chile

Examination of two close collections of Plocamium cartilagineum separated into plants bearing carposporophyte, tetrasporophyte and gametophyte yielded the same qualitative chemical composition, but the three reproductive phases have quantitative differences. We designate chemotype β to the collection which contains brominated monoterpenes and chemotype α to the group which lacks the enzymatic system which incorporates bromine. © 1988