7 research outputs found
Length-weight relationship and a relative condition factor equation for lake sturgeon (Acipenser fulvescens) from the St Clair River system (Michigan, USA)
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Influence of Skipped Spawning and Misspecified Reproductive Schedules on Biological Reference Points in Sustainable Fisheries
- Author
- Publication venue
- 'American Fisheries Society'
- Publication date
- Field of study
Estimation of gonad volume, fecundity, and reproductive stage of shovelnose sturgeon using sonography and endoscopy with application to the endangered pallid sturgeon
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
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- Avihingsanon A
- Avihingsanon A
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- Awori Q
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- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
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- Azbel L
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
Antiseptics and Disinfectants: Activity, Action, and Resistance
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- Walters T. H.
- Wang P.
- Wheeler P. R.
- White D. C.
- Williams N. D.
- Williams N. D.
- Williams N. D.
- Williams N. D.
- Williams N. D.
- Williams N. D.
- Winquist L.
- Wright A. M.
- Wu Z. C.
- Yakabe Y.
- Zavriev S. K.
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
European guidance for the diagnosis and management of osteoporosis in postmenopausal women.
- Author
- A Cranney
- A Cranney
- A Fenton
- A Fouque-Aubert
- A Grey
- A Moayyeri
- A Neuprez
- A Papaioannou
- AC Looker
- AH Myers
- AJ Carr
- AM Sawka
- AN Tosteson
- AV Schwartz
- B Dawson-Hughes
- B Dawson-Hughes
- B Ettinger
- B Jonsson
- BE Nordin
- BM Tang
- C Cooper
- C Keyserlingk von
- C Laet De
- C Ribot
- C Sherrington
- C. Cooper
- CC Gluer
- CC Gluer
- CEDH Laet De
- CH Chesnut 3rd
- CM Klotzbuecher
- Consensus Development Conference
- CR Cardwell
- D Hans
- D Hans
- D Marshall
- D Oliver
- DA Haaland
- Dachverband Osteologie e.V
- DB Hans
- DC Bauer
- DH Solomon
- DJ Torgerson
- DL Kendler
- DM Black
- DM Black
- DM Black
- DM Black
- DP Kiel
- E Barrett-Connor
- E Czerwinski
- E McCloskey
- E Shane
- E Sornay-Rendu
- E. V. McCloskey
- EC
- EM Lewiecki
- ET Middleton
- ET Middleton
- EV McCloskey
- EV McCloskey
- F Borgstrom
- F Borgstrom
- F Borgstrom
- F Lekkerkerker
- F Richy
- F Richy
- G Poor
- GL Anderson
- GL Plosker
- GM Blake
- GM Blake
- GS Collins
- H Johansson
- H Johansson
- H Johansson
- H Smith
- H. Johansson
- HA Bischoff-Ferrari
- HA Pols
- HG Eichler
- HK Genant
- IC Chesnut
- IR Reid
- J Compston
- J Green
- J Hays
- J Hippisley-Cox
- J Reginster
- J. A. Kanis
- J.-Y. Reginster
- JA Cauley
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JC Gallagher
- JE Badurski
- JE Hartle
- JE Roussow
- JJ Caro
- JM Grossman
- JP Bonjour
- JR Lewis
- JR Lewis
- JR Lewis
- JT Schousboe
- JT Schousboe
- JY Reginster
- JY Reginster
- JY Reginster
- JY Reginster
- JY Reginster
- K Briot
- K Engelke
- K Lippuner
- KM Sanders
- KW Lyles
- L Ferrar
- L Giangregorio
- L Mosca
- L Wang
- LM Giangregorio
- M Austin
- M Hiligsmann
- M McClung
- M Pazianas
- M Stevenson
- M Stevenson
- MC Hochberg
- MJ Bolland
- MJ Bolland
- MJ Bolland
- MJ Parker
- MP Lecart
- MR McClung
- MW Tilyard
- N Binkley
- N Zethraeus
- National Institute for Health and Clinical Excellence
- National Institute for Health and Clinical Excellence
- National Osteoporosis Foundation
- NB Watts
- NB Watts
- NB Watts
- ND Nguyen
- NH Bjarnason
- NOF
- NOF
- O Bruyere
- O Bruyere
- O Johnell
- O Johnell
- O Johnell
- O Strom
- O Strom
- P Autier
- P Chen
- P Garnero
- P Kannus
- P Musette
- P Ranjanomennahary
- P Ravn
- PD Delmas
- PD Delmas
- PD Delmas
- PD Delmas
- PD Delmas
- PD Delmas
- PD Miller
- PJ Meunier
- R Eastell
- R Eastell
- R Eastell
- R Eastell
- R Prince
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R. Rizzoli
- RB Mazess
- RD Langer
- RL Fleurence
- RM Neer
- Royal College of Physicians
- Royal College of Physicians
- Royal College of Physicians and Bone and Tooth Society of Great Britain
- RT Chlebowski
- RT Chlebowski
- S Baim
- S Baim
- S Boonen
- S Boonen
- S Boonen
- S Fujiwara
- S Papapoulos
- S Ross
- S Sarkar
- S Tas
- S Vasikaran
- S Wassertheil-Smoller
- SA Khan
- SA Shumaker
- SIGN
- SL Hui
- SL Silverman
- SL Silverman
- SP Shrader
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- ST Harris
- ST Harris
- T Nguyen
- T Vokes
- TE Howe
- TJ Villiers de
- TP Staa Van
- U Persson
- V Elliot-Gibson
- V Rabenda
- V Rabenda
- V Rabenda
- VG Vogel
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WHO
- World Health Organisation
- YL Michael
- YZ Bagger
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis. INTRODUCTION: The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This manuscript updates these in a European setting. METHODS: Systematic literature reviews. RESULTS: The following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture risk, general and pharmacological management of osteoporosis, monitoring of treatment, assessment of fracture risk, case finding strategies, investigation of patients and health economics of treatment. CONCLUSIONS: A platform is provided on which specific guidelines can be developed for national use
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
- Author
- A Cranney
- A Diez-Perez
- A Diez-Perez
- A Fenton
- A Grey
- A Moayyeri
- A OdĂŠn
- AA Ismail
- AA Khan
- AC Tricco
- AG Ellis
- AG Ellis
- AJ Carr
- AM Sawka
- AR McLellan
- AR McLellan
- AV Schwartz
- B Ettinger
- BC Silva
- BE Nordin
- BM Tang
- BZ Leder
- C Durosier-Izart
- C Meier
- C Neuerburg
- C Ribot
- C Sherrington
- C von Keyserlingk
- C. Cooper
- CC Gluer
- CM BrandĂŁo
- CM Klotzbuecher
- CM Weaver
- Consensus Development Conference
- CP Edmondson
- CR Cardwell
- D Feskanich
- D Grigorie
- D Marsh
- D Marshall
- D Oliver
- DA Haaland
- DA Turner
- DB Jepsen
- DH Solomon
- DJ Torgerson
- DM Black
- DM Black
- DM Black
- DM Black
- DM Black
- DM Black
- DP Beall
- DP Kiel
- E Barrett-Connor
- E Biver
- E Laird
- E Marseille
- E McCloskey
- E McCloskey
- E McCloskey
- E Shane
- E Sornay-Rendu
- E Tsourdi
- EM Lewiecki
- EM Umland
- EV McCloskey
- EV McCloskey
- EV McCloskey
- EV McCloskey
- EV McCloskey
- EV McCloskey
- EV McCloskey
- EV McCloskey
- F Borgstrom
- F Cosman
- F Cosman
- F Cosman
- F El-Khoury
- F Johannesdottir
- F Lekkerkerker
- F Richy
- F Richy
- G Bianchi
- G Poor
- GC Chen
- GM Blake
- H Johansson
- H Johansson
- H Johansson
- H Johansson
- H Johansson
- H Johansson
- H Smith
- H Wang
- H Zhang
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Fink
- HA Morris
- HB Shao
- HG Bone
- HG Bone
- IC Chesnut
- ID Papanastassiou
- IJA de Bruin
- IR Reid
- J Compston
- J Compston
- J Green
- J Hays
- J Hippisley-Cox
- J Howe
- J Jolette
- J Leal
- J Reginster
- J.-Y. Reginster
- J.A. Kanis
- JA Cauley
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JC Davis
- JC Gallagher
- JE Hartle
- JE Manson
- JE Roussow
- JG Zhao
- JH Lee
- JJ Caro
- JL Vahle
- JR Curtis
- JR Lewis
- JR Lewis
- JR Lewis
- JS Bae
- JY Reginster
- K Akesson
- K Engelke
- K Ganda
- K Iglay
- K Kayan
- K Kim
- K Lippuner
- K Nimdet
- Kanis JA on behalf of the WHO Scientific Group
- KE Ensrud
- KF Axelsson
- KM Sanders
- KW Lyles
- L Bondo
- L Giangregorio
- L Langsetmo
- L Mosca
- L Shepstone
- LD Gillespie
- LM Giangregorio
- LM Smith
- M Austin
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Hiligsmann
- M Pazianas
- M Pazianas
- M Stevenson
- M Tadrous
- MA Mignot
- MC Hochberg
- ME Kraenzlin
- MG Donaldson
- MJ Bolland
- MJ Bolland
- MJ Bolland
- MJ Gardner
- MJ Parker
- MK Javaid
- MP Lecart
- MR McClung
- MR McClung
- MS Cooper
- MW Tilyard
- N Binkley
- National Institute for Health and Care Excellence
- NB Watts
- NB Watts
- NC Harvey
- NC Harvey
- NC Harvey
- NC Harvey
- NC Harvey
- NC Harvey
- NC Harvey
- NC Harvey
- ND Nguyen
- NH Bjarnason
- O Ethgen
- O Johnell
- O Strom
- O Strom
- P Anagnostis
- P Chen
- P Hadji
- P Makras
- P Martineau
- PD Delmas
- PD Delmas
- PD Delmas
- PD Delmas
- PD Miller
- PD Miller
- PD Miller
- R Dell
- R Eastell
- R Prince
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Rizzoli
- R Zebaze
- R. Rizzoli
- RD Langer
- RD Langer
- RM Neer
- RP Meier
- RR Love
- RT Chlebowski
- RT Chlebowski
- S Boonen
- S Drew
- S Ferrari
- S Ferrari
- S Hawley
- S Hawley
- S Lekamwasam
- S Luthman
- S Palacios
- S Ross
- S Rozenberg
- S Sarkar
- S Vasikaran
- S Wassertheil-Smoller
- SA Khan
- SC Kim
- SL Brennan
- SL Greenspan
- SL Hui
- SL Silverman
- SL Silverman
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Cummings
- SR Majumdar
- SR Majumdar
- ST Harris
- ST Harris
- T Chevalley
- T Keaveny
- T Nguyen
- T Saito
- T Shiroiwa
- TE Howe
- TJ de Villiers
- TP Van Staa
- U Tarantino
- V Elliot-Gibson
- V Rabenda
- V Rabenda
- V Rabenda
- VG Vogel
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- WD Leslie
- World Health Organization
- YL Michael
- YZ Bagger
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study