4 research outputs found
Synthesis of an IRMOF-1@SiO<sub>2</sub> Core–Shell and Amino-Functionalization with APTES for the Adsorption of Urea and Creatinine Using a Fixed-Bed Column Study
Kidney dysfunction is a clinical disease that disables
the kidneys
to remove the waste products and uremic toxins from the circulation
and may lead to fatal kidney failure. Hemodialysis is advantageous
in this circumstance since it prevents the accumulation of waste products
in the body and facilitates the removal of uremic toxins. However,
hemodialysis cannot entirely remove some uremic toxins, such as urea
and creatinine. In this paper, a high-performance fixed-bed column
for urea and creatinine removal was offered. As a result, a MOF layer
was built on SiO2, which was then amino-functionalized
using APTES. Numerous assays were used to characterize the final adsorbent.
The adsorption of urea and creatinine was evaluated in batch and continuous
conditions. Thus, it was demonstrated that the adsorption behavior
of A(0.2)-IRMOF-1@SiO2 followed the Langmuir isotherm,
and it exhibited the maximum adsorption capacity. The batch experiment
determined that urea and creatinine had an adsorption capacity of
1325.73 and 625.00 mg·g–1, respectively. The
adsorption capacity was increased, which was due to the presence of
amino groups (APTES) on the MOF surface. The continuous operation
was evaluated using the A(0.2)-IRMOF-1@SiO2 fixed-bed column.
Thomas and Nelson’s models were examined to achieve a better
understanding of the adsorption behaviors. The A(0.2)-IRMOF-1@SiO2 fixed-bed column successfully removed 92.57% of urea and
80.47% of creatinine. The separation factor for urea in comparison
to creatinine was 2.40 in the A(0.2)-IRMOF-1@SiO2 fixed-bed
column