Microstructure of single-droplet granules formed from ultra-fine powders

A quantitative analysis of variations in granule microstructure based upon changes in primary particle size and bed preparation is presented. The granule microstructures are obtained using X-Ray Computed Tomography (XRCT). An algorithm is developed to measure the number and size of macro-voids (pore space with volume equivalent size greater than or equal to 30 μm or 3 times the primary particle size). Four size fractions of alumina, ranging in primary particle size from 0.5 μm to 108 μm, are sieved using three different sieve sizes to create static powder beds from which single-droplet granules are produced. The analysis shows that large macro-voids exist in ultra-fine powders (0.1–10 μm). The macro-voids take up to 7% of the granule volume and the largest macro-voids are 200–700 μm in volume equivalent size. Changing the sieve preparation changes the size and total volume of macro-voids. In contrast, there are very few macro-voids in granules formed from coarser powders. This study shows that micron sized powders have the opportunity to form complex structures during granulation and that the handling history of the materials should receive greater scrutiny than it currently gets

Modeling the breakage stage in spheronization of cylindrical paste extrudates

Funder: The University of QueenslandAbstract: Spheronization of cylindrical extrudates on a rotating friction plate involves breakage and rounding. Little attention has been given to the breakage stage and quantitative modeling of this process is scarce. Two simple models are compared with experimental data obtained for the early stages of spheronization of microcrystalline cellulose/water extrudates. Tests were conducted for different times (t), rotational speeds (ω), initial loadings, and on pyramidal friction plates with different dimensions. The first model, describing the number of pellets, validated ω3t as a characteristic time scale for the breakage stage. The kinetic parameters obtained by fitting showed a systematic dependence on plate dimensions expressed as a scaled gap width. The second model, a simple population balance, described the evolution of the number and length of pellets. The pseudo rate constants provided insights into the kinetics: extrudates tended to break near the middle, while breakage of smaller pellets was slowed down by more pellet–pellet collisions

Who still dies young in a rich city? Revisiting the case of Oxford

There are substantial inequalities in mortality and life expectancy in England, strongly linked to levels of deprivation. Mortality rates among those who are homeless are particularly high. Using the city of Oxford (UK) as a case study, we investigate ward-level premature standardised mortality ratios for several three-year and five-year periods between 2002 and 2016, and explore the extent to which the mortality of people who become homeless contributed to any rise or fall in geographical inequalities during this period. Age–sex standardised mortality ratios (SMRs) for people aged under 65 years old, with and without deaths among the homeless population, were calculated using Office for National Statistics Death Registration data for England and Wales 2002−2016. Individuals who were homeless or vulnerably housed were identified using records supplied by a local Oxford homeless charity. We found that in an increasingly wealthy, and healthy, city there were persistent ward-level inequalities in mortality, which the city-wide decrease in premature mortality over the period masked. Premature deaths among homeless people in Oxford became an increasingly important contributor to the overall geographical inequalities in health in this city. In the ward with the highest SMR, deaths among the homeless population accounted for 73% of all premature deaths of residents over the whole period; in 2014–2016 this proportion rose to 88%. Homelessness among men (the vast majority of the known homeless population) in this gentrifying English city rose to become the key explanation of geographical mortality patterns in deaths before age 65 across the entire city, particularly after 2011. Oxford reflects a broader pattern now found in many places across England of increasing homeless deaths, widening geographical inequalities in life expectancy, and sharp increases in all-age SMRs. The answer to the question, “Who dies young in a rich, and in fact an even richer, place?” is – increasingly – the homeless

Minimising treatment-associated risks in systemic cancer therapy

Aim of the review To review the consequences of drug-related problems (DRP) in systemic cancer therapy and identify specific contributions of the pharmacist to minimise treatment-associated risks. Method Searches in PubMed, Embase and the Cochrane Library were conducted. Bibliographies of retrieved articles were examined for additional references. Only papers in English between 1980 and 2007 were included. Results In systemic cancer therapy there is an enormous potential for DRP due to the high toxicity and the complexity of most therapeutic regimens. The most frequently reported DRP can be classified into adverse effects, drug–drug interactions, medication errors, and non-adherence. Pharmacists have enhanced efforts to assure quality and safety in systemic cancer therapy together with other health care providers. In consequence, oncology pharmacy has evolved as a novel specialist discipline. The endeavour to merge and co-ordinate individual activities and services of the pharmacist has led to pharmaceutical care concepts which aim at offering novel solutions to the various DRP. Conclusion Pharmaceutical care for cancer patients should be developed within research projects and integrated into disease management programs in order to ensure broad implementation

An evaluation of Dasher with a high-performance language model as a gaze communication method

Dasher is a promising fast assistive gaze communication method. However, previous evaluations of Dasher have been inconclusive. Either the studies have been too short, involved too few participants, suffered from sampling bias, lacked a control condition, used an inappropriate language model, or a combination of the above. To rectify this, we report results from two new evaluations of Dasher carried out using a Tobii P10 assistive eye-tracker machine. We also present a method of modifying Dasher so that it can use a state-of-the-art long-span statistical language model. Our experimental results show that compared to a baseline eye-typing method, Dasher resulted in significantly faster entry rates (12.6 wpm versus 6.0 wpm in Experiment 1, and 14.2 wpm versus 7.0 wpm in Experiment 2). These faster entry rates were possible while maintaining error rates comparable to the baseline eye-typing method. Participants' perceived physical demand, mental demand, effort and frustration were all significantly lower for Dasher. Finally, participants significantly rated Dasher as being more likeable, requiring less concentration and being more fun. © 2014 ACM