Child’s play: Exposure to household pesticide use among children in rural, urban and informal areas of South Africa

Background. As part of a larger dermatological investigation undertaken in 1999 - 2001 involving the Department of Dermatology, Groote Schuur Hospital (Cape Town, South Africa) and Nottingham University (UK), household pesticide use was investigated among Xhosa-speaking families living in three areas in South Africa (a rural area, an urban township and an informal settlement).Objectives. The aim was to characterise pesticide use patternsand potential exposures through skin absorption, ingestion and inhalation for this group of South African children.Methods. A standardised questionnaire, which included a section investigating household pesticide use, was administered by four trained fieldworkers to the parents/guardians of the 740 children (25%) aged between 3 and 11 years identified as having atopic dermatitis either by clinical examination or according to the UK criteria (rural N=387,urban N=292, informal N=61).Results. Of the children with atopic dermatitis, 539 (73%) had been exposed to household pesticides. Most childhood exposure (89%) occurred in the informal settlements, followed by 78% in the urban area and 63% in the rural area.Conclusions. This research highlighted considerable home environment pesticide exposure of South African children in lower socio-economic groups in rural, urban and informal areas. As children are particularly vulnerable to the short- and long-term health effects of pesticide exposure, further indepth investigation is needed to ascertain and document the health effects associated with such exposure in the home

Charge-imbalance effects in intrinsic Josephson systems

We report on two types of experiments with intrinsic Josephson systems made from layered superconductors which show clear evidence of nonequilibrium effects: 1. In 2-point measurements of IV-curves in the presence of high- frequency radiation a shift of the voltage of Shapiro steps from the canonical value hf/(2e) has been observed. 2. In the IV-curves of double-mesa structures an influence of the current through one mesa on the voltage measured on the other mesa is detected. Both effects can be explained by charge-imbalance on the superconducting layers produced by the quasi-particle current, and can be described successfully by a recently developed theory of nonequilibrium effects in intrinsic Josephson systems.Comment: 8pages, 9figures, submitted to Phys. Rev.

Evaluation of the Galalpha1-3Gal epitope as a host modification factor eliciting natural humoral immunity to enveloped viruses

Human sera contain high levels of natural antibody (Ab) to Galalpha1-3Gal, a terminal glycosidic structure expressed on the surface of cells of mammals other than Old World primates. Incorporation of this determinant onto retroviral membranes by passage of viruses in cells encoding alpha-1-3-galactosyltransferase (GT) renders retroviruses sensitive to lysis by natural Ab and complement in normal human serum (NHS). Plasma membrane-budding viruses representing four additional virus groups were examined for their sensitivities to serum inactivation after passage through human cell lines that lack a functional GT or human cells expressing recombinant porcine GT. The inactivation of lymphocytic choriomeningitis virus (LCMV) by NHS directly correlated with host modification of the virus via expression of Galalpha1-3Gal and was blocked by incorporation of soluble Galalpha1-3Gal disaccharide into the inactivation assay. GT-deficient mice immunized to make high levels of Ab to Galalpha1-3Gal (anti-Gal Ab) were tested for resistance to LCMV passaged in GT-expressing cells. Resistance was not observed, but in vitro analyses of the mouse immune sera revealed that the antiviral activity of the sera was insufficient to eliminate LCMV infectivity on its natural targets of infection, macrophages, which express receptors for Ab and complement. Newcastle disease virus and vesicular stomatitis virus (VSV) were inactivated by NHS regardless of cell passage history, whereas Sindbis virus (SV) passaged in human cells resisted inactivation. Both VSV and SV passaged in Galalpha1-3Gal-expressing human cells incorporated this sugar moiety onto their major envelope glycoproteins. SV passaged in mouse cells expressing Galalpha1-3Gal was moderately sensitive to inactivation by NHS. These results indicate that enveloped viruses expressing Galalpha1-3Gal differ in their sensitivities to NHS and that a potent complement source, such as that in NHS, is required for efficient inactivation of sensitive viruses in vitro and in vivo

Cambial Phenology Informs Tree-Ring Analysis of Fire Seasonality in Coastal Plain Pine Savannas

© 2018, The Author(s). Understanding of historical fire seasonality should facilitate development of concepts regarding fire as an ecological and evolutionary process. In tree-ring based fire-history studies, the seasonality of fire scars can be classified based on the position of the fire scar within or between growth rings. Cambial phenology studies are needed to precisely relate a fire-scar position to months within a year because the timing of dormancy, earlywood production, and latewood production varies by species and location. We examined cambial phenology patterns of longleaf pine (Pinus palustris Mill.), slash pine (P. elliottii Engelm.), and South Florida slash pine (P. densa [Little & K.W Dorman] Silba) at sites in southern Georgia and south-central and northern Florida, USA. We developed long-term (2.5 yr to 12 yr) datasets of monthly growth and dormancy and determined when trees transitioned from producing early-wood to producing latewood each year. Most trees were dormant for a period of 1 to 2 months in the winter and transitioned from earlywood to latewood in June. Given the annual growth ring morphology of the pines that we studied and the timing of the lightning-fire season in our study area, we propose a new classification system for assigning seasonality to fire scars found in the three native upland pine species that we studied. This new system, which we name the Coastal Plain Pine System, accounts for the large proportion of latewood typical of these pines and includes a position (the transition position) that corresponds with the time of year when lightning fires occur most frequently. Our findings demonstrate how cambial phenology data can improve interpretation of fire-scar data for determining historical fire seasonality

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B

Serum protein types were determined in eight recipients and donors in cases of hepatic homotransplantation. A change from recipient type to donor type was observed for factor B, C8, orosomucoid, haptoglobin, transferrin, α1-antitrypsin, C3 and C6, but not for Gm and Inv immunoglobulin markers. The results indicate that all the proteins studied (except immunoglobulins) are produced primarily by the liver in vivo. © 1980

Keep it SMPL: Automatic Estimation of 3D Human Pose and Shape from a Single Image

We describe the first method to automatically estimate the 3D pose of the human body as well as its 3D shape from a single unconstrained image. We estimate a full 3D mesh and show that 2D joints alone carry a surprising amount of information about body shape. The problem is challenging because of the complexity of the human body, articulation, occlusion, clothing, lighting, and the inherent ambiguity in inferring 3D from 2D. To solve this, we first use a recently published CNN-based method, DeepCut, to predict (bottom-up) the 2D body joint locations. We then fit (top-down) a recently published statistical body shape model, called SMPL, to the 2D joints. We do so by minimizing an objective function that penalizes the error between the projected 3D model joints and detected 2D joints. Because SMPL captures correlations in human shape across the population, we are able to robustly fit it to very little data. We further leverage the 3D model to prevent solutions that cause interpenetration. We evaluate our method, SMPLify, on the Leeds Sports, HumanEva, and Human3.6M datasets, showing superior pose accuracy with respect to the state of the art.Comment: To appear in ECCV 201

Ladder approximation to spin velocities in quantum wires

The spin sector of charge-spin separated single mode quantum wires is studied, accounting for realistic microscopic electron-electron interactions. We utilize the ladder approximation (LA) to the interaction vertex and exploit thermodynamic relations to obtain spin velocities. Down to not too small carrier densities our results compare well with existing quantum Monte-Carlo (QMC) data. Analyzing second order diagrams we identify logarithmically divergent contributions as crucial which the LA includes but which are missed, for example, by the self-consistent Hartree-Fock approximation. Contrary to other approximations the LA yields a non-trivial spin conductance. Its considerably smaller computational effort compared to numerically exact methods, such as the QMC method, enables us to study overall dependences on interaction parameters. We identify the short distance part of the interaction to govern spin sector properties.Comment: 6 pages, 6 figures, to appear in Physical Review