Implementation of packaged integrated antenna with embedded front end for Bluetooth applications

The design, integration and realization of system in enhanced package approach towards fully functional system level integration by using a compact Bluetooth USB dongle as the demonstrator is presented here. The integration was done on FR4 substrates, which is totally compatible with today’s printed circuit board manufacturing capability. A commercially available Bluetooth integrated chip was chosen as the chipset of our demonstrator, and a package integrated antenna together with an embedded front end completes the system in package integration. The front end developed here is based on an embedded meander line combline filter and an embedded transformer balun. The filter has a 35% area reduction when compared with the classical combline filter and similar performance. The balun has the coils distributed on three layers that minimized the board area needed it and optimizes the performances. The proposed packaged integrated antenna approach is successfully demonstrated here and the new module shows excellent performance when compared with a commercial solution, surpassing the normal Bluetooth class II dongle range which is up to 10 m and increasing the module range up to 120 m without an extra power amplifier

Impact of body tilt on the central aortic pressure pulse.

The present work was undertaken to investigate, in young healthy volunteers, the relationships between the forward propagation times of arterial pressure waves and the timing of reflected waves observable on the aortic pulse, in the course of rapid changes in body position. 20 young healthy subjects, 10 men, and 10 women, were examined on a tilt table at two different tilt angles, -10° (Head-down) and + 45° (Head-up). In each position, carotid-femoral (Tcf) and carotid-tibial forward propagation times (Tct) were measured with the Complior device. In each position also, the central aortic pressure pulse was recorded with radial tonometry, using the SphygmoCor device and a generalized transfer function, so as to evaluate the timing of reflected waves reaching the aorta in systole (onset of systolic reflected wave, sT1r) and diastole (mean transit time of diastolic reflected wave, dMTT). The position shift from Head-up to Head-down caused a massive increase in both Tct (women from 130 ± 10 to 185 ± 18 msec P < 0.001, men from 136 ± 9 to 204 ± 18 msec P < 0.001) and dMTT (women from 364 ± 35 to 499 ± 33 msec P < 0.001, men from 406 ± 22 to 553 ± 21 msec P < 0.001). Mixed model regression showed that the changes in Tct and dMTT observed between Head-up and Head-down were tightly coupled (regression coefficient 2.1, 95% confidence interval 1.9-2.3, P < 0.001). These results strongly suggest that the diastolic waves observed on central aortic pulses reconstructed from radial tonometric correspond at least in part to reflections generated in the lower limbs

Highly enriched Betaproteobacteria growing anaerobically with p-xylene and nitrate

The identity of the microorganisms capable of anaerobic p-xylene degradation under denitrifying conditions is hitherto unknown. Here, we report highly enriched cultures of freshwater denitrifying bacteria that grow anaerobically with p-xylene as the sole organic carbon source and electron donor. Long curved rods, with 95% 16S rRNA gene sequence identity to Denitratisoma oestradiolicum, dominated the enrichment cultures (>91% of all cells), as detected by phylotype-specific probes. These Rhodocyclaceae microorganisms were distantly related to other denitrifying hydrocarbon-degrading Betaproteobacteria from the Azoarcus-Thauera clade. Complete oxidation p-xylene to CO(2) coupled to denitrification was suggested by quantitative measurements of substrate consumption. Metabolite analysis identified (4-methylbenzyl)succinate and (4-methylphenyl)itaconate, suggesting addition to fumarate as an initial activation reaction

Angelman Syndrome: From Mouse Models to Therapy

The UBE3A gene is part of the chromosome 15q11-q13 region that is frequently deleted or duplicated, leading to several neurodevelopmental disorders (NDD). Angelman syndrome (AS) is caused by the absence of functional maternally derived UBE3A protein, while the paternal UBE3A gene is present but silenced specifically in neurons. Patients with AS present with severe neurodevelopmental delay, with pronounced motor deficits, absence of speech, intellectual disability, epilepsy, and sleep problems. The pathophysiology of AS is still unclear and a treatment is lacking. Animal models of AS recapitulate the genotypic and phenotypic features observed in AS patients, and have been invaluable for understanding the disease process as well as identifying apropriate drug targets. Using these AS mouse models we have learned that loss of UBE3A probably affects many areas of the brain, leading to increased neuronal excitability and a loss of synaptic spines, along with changes in a number of distinct behaviours. Inducible AS mouse models have helped to identify the critical treatment windows for the behavioral and physiological phenotypes. Additionally, AS mouse models indicate an important role for the predominantly nuclear UBE3A isoform in generating the characteristic AS pathology. Last, but not least, the AS mice have been crucial in guiding Ube3a gene reactivation treatments, which present a very promising therapy to treat AS

Spin-glass state and long-range magnetic order in Pb(Fe1/2Nb1/2)O3

We have investigated the magnetic ground-state of the multiferroic relaxor ferroelectric \pfn with $\mu$SR spectroscopy and neutron scattering. We find that a transition to a partially disordered phase occurs below T=20 K that coexists with long-range antiferromagnetic ordering. The disordered phase resembles a spin-glass. No clustering of magnetic ions could be evidenced by $\mu$SR so that the coexistence appears homogeneous in the sample

Un procedeu original de construcţie şi utilizare a lamboului nazogenian

Introduction. The classical naso-labial fl ap used for the reconstruction of tongue and oral floor presents multiple drawbacks. As an alternative to the classical one we present an original procedure of preparation of the naso-labial fl ap evaluated after seven years of use. Material and Method. The procedure we used was fi rst applied in the Oral and Maxillofacial Surgery Clinic in Cluj-Napoca seven years ago on patients suffering from tongue and/or oral floor malignancies in order to reconstruct these anatomical areas after the excision of the tumours in oncological safe limits. Most of its preparation procedure was made according to the classical method with some modifi cations in the preparation of its base. In order to enhance its covering area and functional availability and to eliminate some drawbacks, the route to the receptor area was changed. The submandibular course was used instead of the transbuccal one. Results. In all 21 patients who underwent surgery, a considerable enhancement of fl ap covering availability was obtained. It was able to cover defects ranging from the posterior limits of the tongue and oral fl oor to the tongue tip even beyond the midline. Unlike in the classical method there was no need to perform tooth extractions in dentulous patients. It is a one step procedure. Thus, the second step of the classical method was eliminated. Conclusions. The naso-labial fl ap with submandibular course offers covering and functional availability superior than the classical one with transbuccal route. It preserves and reconstructs the perimandibular anatomical sites. It also shortens the surgical treatment period of tongue and oral floor malignancies

Роды у беременных с преждевременным разрывом околоплодных оболочек в срок

Universitatea de Medicină şi Farmacie «Nicolae Testemiţanu», Catedra de Obstetrică şi Ginecologie nr. 1Summary. The management of labor in women with prenatal rupture of amniotic membranes at term has become less a clinical dilemma compared to past decades. All these were possible due to the wider understanding of the mechanisms of production of this phenomenon, the mechanism of complications development as well as the broad possibilities of intrapartum actions. However, prenatal rupture of amniotic membranes at term presents a risk of vital complications for the mother and for the newborn.Резюме. Тактика ведения родов у беременных с преждевременным разрывом околоплодных оболочек в срок стала менее актуальной по сравнению с прошлыми десятилетиями. Все это стало возможным благодаря пониманию механизмов развития этого процесса, осложнений, а также широких возможностей для действий на протяжении родов. Однако пренатальный разрыв амниотических мембран в срок представляет собой риск появления осложнений имеющих жизненно важное значение, как для матери, так и для новорожденного

Spectroscopy of 35^{35}P using the one-proton knockout reaction

The structure of $^{35}$P was studied with a one-proton knockout reaction at88~MeV/u from a $^{36}$S projectile beam at NSCL. The $\gamma$ rays from thedepopulation of excited states in $^{35}$P were detected with GRETINA, whilethe $^{35}$P nuclei were identified event-by-event in the focal plane of theS800 spectrograph. The level scheme of $^{35}$P was deduced up to 7.5 MeV using$\gamma-\gamma$ coincidences. The observed levels were attributed to protonremovals from the $sd$-shell and also from the deeply-bound $p\_{1/2}$ orbital.The orbital angular momentum of each state was derived from the comparisonbetween experimental and calculated shapes of individual ($\gamma$-gated)parallel momentum distributions. Despite the use of different reactions andtheir associate models, spectroscopic factors, $C^2S$, derived from the$^{36}$S $(-1p)$ knockout reaction agree with those obtained earlier from$^{36}$S($d$,\nuc{3}{He}) transfer, if a reduction factor $R\_s$, as deducedfrom inclusive one-nucleon removal cross sections, is applied to the knockout transitions.In addition to the expected proton-hole configurations, other states were observedwith individual cross sections of the order of 0.5~mb. Based on their shiftedparallel momentum distributions, their decay modes to negative parity states,their high excitation energy (around 4.7~MeV) and the fact that they were notobserved in the ($d$,\nuc{3}{He}) reaction, we propose that they may resultfrom a two-step mechanism or a nucleon-exchange reaction with subsequent neutronevaporation. Regardless of the mechanism, that could not yet be clarified, thesestates likely correspond to neutron core excitations in \nuc{35}{P}. Thisnewly-identified pathway, although weak, offers the possibility to selectivelypopulate certain intruder configurations that are otherwise hard to produceand identify.Comment: 5 figures, 1 table, accepted for publication in Physical Review

Investment case for two-year post university speciality training in family medicine in Tajikistan: how much is needed for continuing and scaling up the improved education of family doctors?

Background: A new two-year Post University Specialty Training (PUST) programme in family medicine was introduced to improve the quality of postgraduate speciality medical education in Tajikistan. Postgraduate education of family doctors (FDs) needs to be urgently scaled up, as 38% of FD positions in Tajikistan remained unfilled in 2018. Moreover, the international financial support for the PUST programme is ending. This investment case assesses the minimum funding needed for the continuation and scale-up of PUST and establishes the rationale for the investment in the light of a recent evaluation. Methods: The costs of the programme were calculated for 2018 and a scale-up forecast made for the period 2019-2023. The impact of the scale-up on the shortage of FDs was assessed. An evaluation using a Multiple Choice Questionnaire and Objective Structured Clinical Examination (OSCE) assessed and compared theoretical knowledge, clinical skills and competencies of PUST trained and conventionally trained FDs. Results: The annual costs of the programme were US$228,000 in 2018. The total investment needed for scaling up PUST from 31 new FDs in 2018 to 100 FD graduates each year by 2023 was US$ 802,000.However, when the retirement of FDs and population growth are considered, the scale-up will result only in maintaining the current level of FDs working and not solve the country's FD shortage. The PUST FDs demonstrated significantly better clinical skills than the conventionally trained interns, scoring 60 and 45% of OSCE points, respectively. Theoretical knowledge showed a similar trend; PUST FDs answered 44% and interns 38% of the questions correctly. Conclusions: The two-year PUST programme has clearly demonstrated it produces better skilled family doctors than the conventional one-year internship, albeit some enduring quality concerns do still prevail. The discontinuation of international support for PUST would be a major setback and risks potentially losing the benefits of the programme for family medicine and also other specialities. To guarantee the supply of adequately trained FDs and address the FD shortage, the PUST should be continued and scaled up. Therefore, it is essential that international support is extended and a gradual transition to sustainable national financing gets underway