Risk preference based option pricing in a fractional Brownian market

We focus on a preference based approach when pricing options in a market driven by fractional Brownian motion. Within this framework we derive formulae for fractional European options using the traditional idea of conditional expectation. The obtained formulae - as well as further results - accord with classical Brownian theory and con?rm economic intuition towards fractional Brownian motion. Furthermore the in?uence of the Hurst parameter H on the price of a European option will be analyzed. --Fractional Brownian motion,Conditional expectation,Risk preference based option pricing,Fractional option pricing,Fractional Greeks

Risk preference based option pricing in a fractional Brownian market

We focus on a preference based approach when pricing options in a market driven by fractional Brownian motion. Within this framework we derive formulae for fractional European options using the traditional idea of conditional expectation. The obtained formulae – as well as further results – accord with classical Brownian theory and confirm economic intuition towards fractional Brownian motion. Furthermore the influence of the Hurst parameter H on the price of a European option will be analyzed

A holistic system approach for short range passenger aircraft with cryogenic propulsion system

Currently, hybrid-electric aircraft are under investigation as one possible solution to reduce the emissions of the aviation industry according to Flightpath 2050 of the European Union. To meet the drive trainʼs requirements on low mass while aiming for highest efficiency, superconducting technologies are regarded as a key enabling technology for drive train powers of several tens of megawatts. Within the German nationally funded project TELOS an exemplary mission profile and the physical measures of a 220-passenger aircraft are used to derive the requirements for a cryogenic-cooled serial hybrid-electric propulsion system. To optimize the total system performance, we subsequently evaluated the superconducting and cryogenic-cooled components by using computationally fast, analytical models. This approach allows quantifying the system performance by using component technologies being available today. In particular, the system performance of geared drive to direct drive propulsion units are compared and the influence of the DC bus voltage and the electric frequencies of the AC circuits on the mass and the efficiency of the drive trains are analysed

The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1

AbstractWe demonstrate that HPV-16 E7 forms a complex with Miz-1. UV-induced expression of the CDK-inhibitor p21Cip1 and subsequent cell cycle arrest depends upon endogenous Miz-1 in HPV-negative C33A cervical cancer cells containing mutated p53. Transient expression of E7 in C33A inhibits UV-induced expression of p21Cip1 and overcomes Miz-1-induced G1-phase arrest. The C-terminal E7Δ79LEDLL83-mutant with reduced Miz-1-binding capacity was impaired in its capability to repress p21Cip1 expression; whereas the pRB-binding-deficient E7C24G-mutant inhibited p21Cip1 expression similar to wild-type E7. Using ChIP, we demonstrate that endogenous E7 is bound to the endogenous p21Cip1 core-promoter in CaSki cells and RNAi-mediated knock down of Miz-1 abrogates E7-binding to the p21Cip1 promoter. Co-expression of E7 with Miz-1 inhibited Miz-1-induced p21Cip1 expression from the minimal-promoter via Miz-1 DNA-binding sites. Co-expression of E7Δ79LEDLL83 did not inhibit Miz-1-induced p21Cip1 expression. E7C24G retained E7-wild-type capability to inhibit Miz-1-dependent transactivation. These findings suggest that HPV-16 E7 can repress Miz-1-induced p21Cip1 gene expression

Implementation of stroke teams and simulation training shortened process times in a regional stroke network-A network-wide prospective trial.

To meet the requirements imposed by the time-dependency of acute stroke therapies, it is necessary 1) to initiate structural and cultural changes in the breadth of stroke-ready hospitals and 2) to find new ways to train the personnel treating patients with acute stroke. We aimed to implement and validate a composite intervention of a stroke team algorithm and simulation-based stroke team training as an effective quality initiative in our regional interdisciplinary neurovascular network consisting of 7 stroke units.We recorded door-to-needle times of all consecutive stroke patients receiving thrombolysis at seven stroke units for 3 months before and after a 2 month intervention which included setting up a team-based stroke workflow at each stroke unit, a train-the-trainer seminar for stroke team simulation training and a stroke team simulation training session at each hospital as well as a recommendation to take up regular stroke team trainings.The intervention reduced the network-wide median door-to-needle time by 12 minutes from 43,0 (IQR 29,8-60,0, n = 122) to 31,0 (IQR 24,0-42,0, n = 112) minutes (p < 0.001) and substantially increased the share of patients receiving thrombolysis within 30 minutes of hospital arrival from 41.5% to 59.6% (p < 0.001). Stroke team training participants stated a significant increase in knowledge on the topic of acute stroke care and in the perception of patient safety. The overall course concept was regarded as highly useful by most participants from different professional backgrounds.The composite intervention of a binding team-based algorithm and stroke team simulation training showed to be well-transferable in our regional stroke network. We provide suggestions and materials for similar campaigns in other stroke networks