Input shaping for PFC: how and why?

Predictive functional control (PFC) is a highly successful strategy within industry, but for cases with challenging dynamics the most effective tuning approaches are still an active research area. This paper shows how one can deploy some insights from the more traditional model predictive control literature in order to enable systematic tuning and in particular, to ensure that the key PFC tuning parameter, that is the desired closed-loop time constant, is effective. In addition to enabling easier and more effective tuning, the proposed approach has the advantage of being simple to code and thus retaining the simplicity of implementation and tuning that is a key selling point of PFC. This paper focuses on design for open-loop unstable and also processes with significant under-damping in their open-loop behaviour

Surface electrical properties experiment, part 1

The work is reported which was performed on the Surface Electrical Properties Experiment Data Acquisition System. Areas discussed include: data handling and processing, installation and external signal application, operation of the equipment, and digital output. Detailed circuit descriptions are included

Reproducibility of NIRS Assessment of Muscle Oxidative Capacity in Smokers With and Without COPD

Low muscle oxidative capacity contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Near-infrared spectroscopy (NIRS) allows non-invasive determination of the muscle oxygen consumption (mV̇O2) recovery rate constant (k), which is proportional to oxidative capacity assuming two conditions are met: 1) exercise intensity is sufficient to fully-activate mitochondrial oxidative enzymes; 2) sufficient O2 availability. We aimed to determine reproducibility (coefficient of variation, CV; intraclass correlation coefficient, ICC) of NIRS k assessment in the gastrocnemius of 64 participants with (FEV1 64 ± 23%predicted) or without COPD (FEV1 98 ± 14%predicted). 10–15 s dynamic contractions preceded 6 min of intermittent arterial occlusions (5–10 s each, ∼250 mmHg) for k measurement. k was lower (P < 0.05) in COPD (1.43 ± 0.4 min−1; CV = 9.8 ± 5.9%, ICC = 0.88) than controls (1.74 ± 0.69 min−1; CV = 9.9 ± 8.4%; ICC = 0.93). Poor k reproducibility was more common when post-contraction mV̇O2 and deoxygenation were low, suggesting insufficient exercise intensity for mitochondrial activation and/or the NIRS signal contained little light reflected from active muscle. The NIRS assessment was well tolerated and reproducible for muscle dysfunction evaluation in COPD

The Effect of Water Deficits during Flowering and Seed Production on Cultivars of Subterranean Clover and Annual Medic

In improved pastures in inland southern Australia, the persistence and growth of annual pasture legumes depends in part on their ability to produce and conserve abundant seed for regeneration and production. For near-maximum seed production in spring, adequate soil water is needed for at least 70 days in subterranean clover (Trifolium subterraneum) and medic (Medicago) species. Water deficits during spring are a common occurrence, and they appear to be increasing in frequency. The effect of relatively short periods of water deficit during reproductive development has received some attention but the findings conflict. The present experiment was conducted to examine further the responses of subterranean clover to water deficits imposed during the reproductive phase, and to compare the response of medic to that of subterranean clover. The flowering of two early strains of subterranean clover (Northam, Daglish) was synchronised with two early-flowering cultivars of annual medic (Cyprus barrel medic and Harbinger strand medic). Seed production parameters were observed on four watering treatments (nil, early, mid and late deficits during the reproductive phase). Notable differences occurred between the two genera and between the water treatments in their effect on reproductive development. A highly significant interaction favouring medic was recorded between the legumes (clover, medic) and the early deficit treatment, in that the individual seed weight of medic was slightly enhanced by water stress and clover was significantly depressed. In the mid- and late-stress treatments, a significantly lower proportion of viable seed was recorded with clover versus medic. The implications of the findings for the use of adapted annual legumes are discussed. This research was supported by a Reserve Bank Research Fellowship

Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance

The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle. The recent discovery of their resistance to cancer and exceptional longevity has opened up new and important avenues of research. Part of this resistance to cancer has been attributed to the fact that NMRs produce a modified form of hyaluronan—a key constituent of the extracellular matrix—that is thought to confer increased elasticity of the skin as an adaptation for living in narrow tunnels. This so-called high molecular mass hyaluronan (HMM-HA) stems from two apparently unique substitutions in the hyaluronan synthase 2 enzyme (HAS2). To test whether other subterranean mammals with similar selection pressures also show molecular adaptation in their HAS2 gene, we sequenced the HAS2 gene for 11 subterranean mammals and closely related species, and combined these with data from 57 other mammals. Comparative screening revealed that one of the two putatively important HAS2 substitutions in the NMR predicted to have a significant effect on hyaluronan synthase function was uniquely shared by all African mole-rats. Interestingly, we also identified multiple other amino acid substitutions in key domains of the HAS2 molecule, although the biological consequences of these for hyaluronan synthesis remain to be determined. Despite these results, we found evidence of strong purifying selection acting on the HAS2 gene across all mammals, and the NMR remains unique in its particular HAS2 sequence. Our results indicate that more work is needed to determine whether the apparent cancer resistance seen in NMR is shared by other members of the African mole-rat clade.National Research Foundation (South Africa

Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure

Peak ratios of pulmonary gas-exchange to ventilation during exercise (V˙O2/V˙E and V˙CO2/V˙E, termed "circulatory equivalents") are sensitive to heart failure (HF) severity, likely reflecting low and/or poorly distributed pulmonary perfusion. We tested whether peak V˙O2/V˙E and V˙CO2/V˙E would: (1) distinguish HF patients from controls; (2) be independent of incremental exercise protocol; and (3) correlate with lactate threshold (LT) and ventilatory compensation point (VCP), respectively.Twenty-four HF patients (61±11 years) with reduced ejection fraction (31±8%) and 11 controls (63±7 years) performed ramp-incremental cycle ergometry. Eighteen HF patients also performed slow (5±1 W/min), medium (9±4 W/min), and fast (19±6 W/min) ramps. Peak V˙O2/V˙E and V˙CO2/V˙E from X-Y plot, and LT and VCP from 9-panel plot, were determined by 2 independent, blinded, assessors. Peak V˙O2/V˙E (31.2±4.4 versus 41.8±4.8 mL/L; P<0.0001) and V˙CO2/V˙E (29.3±3.0 versus 36.9±4.0 mL/L; P<0.0001) were lower in HF than controls. Within individuals, there was no difference across 3 ramp rates in peak V˙O2/V˙E (P=0.62) or V˙CO2/V˙E (P=0.97). Coefficient of variation (CV) in peak V˙O2/V˙E was lower than for LT (5.1±2.1% versus 8.2±3.7%; P=0.014), and coefficient of variation in peak V˙CO2/V˙E was lower than for VCP (3.3±1.8% versus 8.7±4.2%; P<0.001). In all participants, peak V˙O2/V˙E was correlated with, but occurred earlier than, LT (r2=0.94; mean bias, -0.11 L/min), and peak V˙CO2/V˙E was correlated with, but occurred earlier than, VCP (r2=0.98; mean bias -0.08 L/min).Peak circulatory equivalents during exercise are strongly associated with (but not identical to) LT and VCP. Peak circulatory equivalents are reliable, objective, effort-independent indices of gas-exchange abnormality in HF