Extension of the C star rotation curve of the Milky Way to 24 kpc

Demers and Battinelli published, in 2007 the rotation curve of the Milky Way based on the radial velocity of carbon stars outside the Solar circle. Since then we have established a new list of candidates for spectroscopy. The goal of this paper is to determine the rotation curve of the galaxy, as far as possible from the galactic center, using N type carbon stars. The stars were selected from their dereddened 2MASS colours, then the spectra were obtained with the Dominion Astrophysical Observatory and Asiago 1.8 meter telescopes. This publication adds radial velocities and Galactrocentric distances of 36 carbon stars, from which 20 are new confirmed. The new results for stars up to 25 kpc from the galactic center, suggest that the rotation curve shows a slight decline beyond the Solar circle.Comment: 13 pages, 3 figures, 1 table; accepted for publication in Astrophysic

Ab initio simulations of Cu binding sites in the N-terminal region of PrP

The prion protein (PrP) binds Cu2+ ions in the octarepeat domain of the N-terminal tail up to full occupancy at pH=7.4. Recent experiments show that the HGGG octarepeat subdomain is responsible for holding the metal bound in a square planar coordination. By using first principle ab initio molecular dynamics simulations of the Car-Parrinello type, the Cu coordination mode to the binding sites of the PrP octarepeat region is investigated. Simulations are carried out for a number of structured binding sites. Results for the complexes Cu(HGGGW)+(wat), Cu(HGGG) and the 2[Cu(HGGG)] dimer are presented. While the presence of a Trp residue and a H2O molecule does not seem to affect the nature of the Cu coordination, high stability of the bond between Cu and the amide Nitrogens of deprotonated Gly's is confirmed in the case of the Cu(HGGG) system. For the more interesting 2[Cu(HGGG)] dimer a dynamically entangled arrangement of the two monomers, with intertwined N-Cu bonds, emerges. This observation is consistent with the highly packed structure seen in experiments at full Cu occupancy.Comment: 4 pages, conference proceedin

Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract.

Anthocyanins are natural colorant belonging to the flavonoid family, widely distributed among flowers, fruits, and vegetables. Some flavonoids have been found to possess anticarcinogenic, cytotoxic, cytostatic, antioxidant, and anti-inflammatory properties. Since increased nitric oxide (NO) plays a role in inflammation, we have investigated whether the pharmacological activity of the anthocyanin fraction of a blackberry extract (cyanidin-3-O-glucoside representing about 88% of the total anthocyanin content) was due to the suppression of NO synthesis. The markedly increased production of nitrites by stimulation of J774 cells with lipopolysaccharide (LPS) for 24 h was concentration-dependently inhibited by the anthocyanin fraction (11, 22, 45, and 90 μg/ml) of the extract. Moreover, this inhibition was dependent on a dual mechanism, since the extract attenuated iNOS protein expression and decreased the iNOS activity in lungs from LPS-stimulated rats. Inhibition of iNOS protein expression appeared to be at the transcriptional level, since the extract and similarly cyanidin-3-O-glucoside (10, 20, 40, and 80 μg/ml, amounts corresponding to the concentrations present in the extract) decreased LPS-induced NF-κB activation, through inhibition of IκBα degradation, and reduced ERK-1/2 phosphorylation in a concentration-dependent manner. In conclusion, our study demonstrates that at least some part of the anti-inflammatory activity of blackberry extract is due to the suppression of NO production by cyanidin-3-O-glucoside, which is the main anthocyanin present in the extract. The mechanism of this inhibition seems to be due to an action on the expression/activity of the enzyme. In particular, the protein expression was inhibited through the attenuation of NF-κB and/or MAPK activatio

Quantum Properties of a Which-Way Detector

We explore quantum properties of a which-way detector using three versions of an idealized two slit arrangements. Firstly we derive complementarity relations for the detector; secondly we show how the "experiment" may be altered in such a way that using single position measurement on the screen we can obtain quantum erasure. Finally we show how to construct a superposition of "wave" and "particle" components

A simple atomistic model for the simulation of the gel phase of lipid bilayers

In this paper we present the results of a large-scale numerical investigation of structural properties of a model of cell membrane, simulated as a bilayer of flexible molecules in vacuum. The study was performed by carrying out extensive Molecular Dynamics simulations, in the (NVE) micro-canonical ensemble, of two systems of different sizes (2x32 and 2x256 molecules), over a fairly large set of temperatures and densities, using parallel platforms and more standard serial computers. Depending on the dimension of the system, the dynamics was followed for physical times that go from few hundred of picoseconds for the largest system to 5--10 nanoseconds for the smallest one. We find that the bilayer remains stable even in the absence of water and neglecting Coulomb interactions in the whole range of temperatures and densities we have investigated. The extension of the region of physical parameters that we have explored has allowed us to study significant points in the phase diagram of the bilayer and to expose marked structural changes as density and temperature are varied, which are interpreted as the system passing from a crystal to a gel phase.Comment: 41 pages, 13 figure

Mars Observer Radar Altimeter Radiometer (MORAR)

The Mars Observer Project will permit the advancement of the state of the topographic and hypsometric knowledge of Mars to a level of 10 m or better over the surface of the planet Mars, the measurement of microwave surface brightness temperature of Mars with an accuracy of 15 to 20 K over 24 hours, and the measurement, globally, of surface returned power related to radar cross section with an accuracy of 1 dB and a repeatability of .5 dB. The MORAR Hardware Development, Ground Data Processing, and the Mission Operations will allow the accomplishment of these scientific objectives to define globally the topography of Mars at sufficient vertical resolution and spatial scale to address both large-scale geophysical and small-scale geologic problems, and to obtain global surface electrical and scattering properties of the upper several centimeters of the Martian surface for assessment of the composition, physical state, and volatile distribution of the surface

\Delta S=2 and \Delta C=2 bag parameters in the SM and beyond from Nf=2+1+1 twisted-mass LQCD

We present unquenched lattice QCD results for the matrix elements of four-fermion operators relevant to the description of the neutral K and D mixing in the Standard Model and its extensions. We have employed simulations with Nf = 2 + 1 + 1 dynamical sea quarks at three values of the lattice spacings in the interval 0.06 - 0.09 fm and pseudoscalar meson masses in the range 210 - 450 MeV. Our results are extrapolated to the continuum limit and to the physical pion mass. Renormalization constants have been determined non-perturbatively in the RI-MOM scheme. In particular, for the Kaon bag-parameter, which is relevant for the \overline{K}^0-K^0 mixing in the Standard Model, we obtain B_K^{RGI} = 0.717(24).Comment: Added comments to error budget discussion; fig.19 corrected. Version to appear in PR