2-(4-Chloro­phen­yl)naphtho­[1,8-de][1,3,2]diaza­borinane

The title compound, C16H12BClN2, is one in a series of diaza­borinanes, derived from 1,8-diaminona­phthalene, featuring substitution at the 1, 2 and 3 positions in the nitro­gen-boron heterocycle. The structure deviates from planarity, the torsion angle subtended by the p-chloro­phenyl ring relative to the nitro­gen–boron heterocycle being −44-.3(3)°. The mol­ecules form infinite chains with strong inter­actions between the vacant pz orbital of the B atom and the π-system of an adjacent mol­ecule. The distance between the B atom and the 10-atom centroid of an adjacent naphthalene ring is 3.381 (4) Å. One N-H H atom is weakly hydrogen bonded to the Cl atom of an adjacent mol­ecule. This combination of inter­molecular inter­actions leads to the formation of an infinite two-dimensional network perpendic­ular to the c axis

2-Phenyl­naphtho­[1,8-de][1,3,2]diaza­borinane

The title compound, C16H13BN2, is one compound in a series of diaza­borinanes featuring substitution at the 1, 2 and 3 positions in the nitro­gen–boron heterocycle. The title compound is slightly distorted from planarity, with a dihedral angle of 9.0 (5)° between the mean planes of the naphthalene system and the benzene ring. The m-carbon atom of the benzene ring exhibits the greatest deviation of 0.164 (2) Å from the 19-atom mean plane defined by all non-H atoms. The two N—B—C—C torsion angles are 6.0 (3) and 5.6 (3)°. In the crystal, mol­ecules are linked by π–π inter­actions into columns, with a distance of 3.92 (3) Å between the naphthalene ring centroids. Adjacent π-stacked columns, co-linear with the b-axis, are linked by C—H⋯π inter­actions

2-[4-(Methyl­sulfan­yl)phen­yl]naphtho[1,8-de][1,3,2]diaza­borinane

The title compound, C17H15BN2S, is one member in a series of diaza­borinanes featuring substitution at the 1-, 2- and 3-positions in the nitro­gen–boron heterocycle. The dihedral angle between the mean planes of the naphthalene and phenyl ring systems is 19.86 (6)°. In the crystal structure, two C—H⋯π inter­actions link the mol­ecules into sheets which lie parallel to the bc plane. There is a π–π inter­action between each pair of centrosymmetrically related sheets [centroid–centroid distance = 3.5922 (8) Å]

Impact of Variant Donor Hepatic Arterial Anatomy on Clinical Graft Outcomes in Liver Transplantation

Standard hepatic arterial anatomy is composed of the common hepatic artery proceeding from the celiac trunk and giving rise to the gastroduodenal artery (GDA) and proper hepatic arteries. Reconstruction of the hepatic arterial supply during liver transplantation, often complex in nature, can be required in cases of accessory or replaced vessels. A recent review summarized the hepatic arterial anatomy reported in over 19,000 cases from 20 individual studies. (1) It has been suggested that the presence of nonstandard donor arterial anatomy may be related to an increased incidence of hepatic artery thrombosis (HAT).(2) Although the overall incidence of HAT is low, it can have devastating effects, including the need for retransplantation, long-term biliary complications, and increased patient mortality. This article describes the arterial anatomy in a large number of liver transplants, with routine anastomosis of a very short hepatic artery and routine reconstruction of the accessory right hepatic artery to the GDA. Study outcomes include incidence of HAT within 30 days of transplant, early graft loss up to 1 year after transplant, and 10-year graft survival

Evaluating the accuracy of hake abundance index predictions using different smoothing techniques

Alternative projection approaches based on linear and quadratic smoothing are applied retrospectively to abundance indices for hake to ascertain whether they can provide more accurate predictions of resource status one and two years ahead, in line with ideal needs for the empirical OMP used to set hake TACs. The results suggest that there is probably little if anything to be gained from attempting more complex formulations than three-year averages of abundance indices for input to a target-based empirical OMP for SA hake

Effect of Hydrologic Restoration on the Habitat of The Cape Sable Seaside Sparrow, Annual Report of 2003-2004

Following on our previous year’s work on ‘Effect of hydrologic restoration on the habitat of the Cape Sable seaside sparrow (CSSS)’, we presented first year results at the Cape Sable seaside sparrow – fire planning workshop at Everglades National Park in December 2003. Later, with almost the same set of crews as in the previous year, we started field work in the first week of January and continued till May 26, 2004. Protocols for sampling topography and vegetation in 2004 were identical to the previous year. In the early season, we completed topographic surveys along two remaining transects, B and E (~16.5 km), and vegetation surveys along three transects, D, E and F (~10.8 km), leaving only the vegetation sampling on transects B and C to be completed in 2005. During April and May, vegetation sampling was completed at 230 census sites, making the total of 409 CSSS census sites for which we have complete vegetation data. We updated data sets from both 2003 and 2004, and analyzed them together using cluster analysis, ordination, weighted-averaging regression and analysis of variance, as we had in 2003. Additionally, we used logistic regression to examine the effect of vegetation structural parameters on the recent occurrence of CSSS. We also analyzed vegetation observations recorded by the sparrow census team in 1981 and annually between 1992 and 2004 to assess historical patterns of vegetation change in CSSS habitat

Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins

DNA vaccination can elicit both humoral and cellular immune responses and can confer protection against several pathogens. However, DNA vaccines expressing the envelope (Env) protein of human immunodeficiency virus (HIV) have been relatively ineffective at generating high titer, long-lasting, neutralizing antibodies in a variety of animal models. In this study, we report that fusion of Env and the complement component, C3d, in a DNA vaccine, enhances the titers of antibody to Env. Plasmids were generated that expressed a secreted form of Env (sgp120) from three isolates of HIV and these same forms fused to three tandem copies of the murine homologue of C3d (sgp120-3C3d). Analyses of titers and avidity maturation of the raised antibody indicated that immunizations with each of the sgp120-3C3d-expressing DNAs accelerated both the onset and the avidity maturation of antibody to Env. Originally published AIDS Research and Human Retroviruses, Vol. 17, No. 9, June 200

Photometric Selection of Emission Line Galaxies, Clustering Analysis and a Search for the ISW effect

We investigate the use of simple colour cuts applied to the SDSS optical imaging to perform photometric selections of emission line galaxies out to z<1. From colour-cuts using the SDSS g, r and i bands, we obtain mean photometric redshifts of z=0.32+-0.08, z=0.44+-0.12 and z=0.65+-0.21. We further calibrate our high redshift selection using spectroscopic observations with the AAOmega spectrograph on the 4m Anglo-Australian Telescope (AAT), observing ~50-200 galaxy candidates in 4 separate fields. With just 1-hour of integration time and with seeing of ~1.6", we successfully determined redshifts for ~65% of the targeted candidates. We calculate the angular correlation functions of the samples and find correlation lengths of r0=2.64 h-1 Mpc, r0=3.62 h-1 Mpc and r0=5.88 h-1 Mpc for the low, mid and high redshift samples respectively. Comparing these results with predicted dark matter clustering, we estimate the bias parameter for each sample to be b=0.70, b=0.92 and b=1.46. We calculate the 2-point redshift-space correlation function at z~0.6 and find a clustering amplitude of s0=6.4 h-1 Mpc. Finally, we use our photometric sample to search for the Integrated Sachs-Wolfe signal in the WMAP 5yr data. We cross-correlate our three redshift samples with the WMAP W, V, Q and K bands and find an overall trend for a positive signal similar to that expected from models. However, the signal in each is relatively weak. Combining all three galaxy samples we find a signal of wTg(<100')=0.20+-0.12 microK in the WMAP W-band, a significance of 1.7sigma.Comment: 14 pages, 17 figures, submitted to MNRA

Investigating the Sustainability of Outcomes in a Chronic Disease Treatment Programme

This study examines trends in chronic disease outcomes from initiation of a specialised chronic disease treatment programme through to incorporation of programme activities into routine service delivery. We reviewed clinical records of 98 participants with confirmed renal disease or hypertension in a remote indigenous community health centre in Northern Australia. For each participant the review period spanned an initial three years while participating in a specialised cardiovascular and renal disease treatment programme and a subsequent three years following withdrawal of the treatment programme. Responsibility for care was incorporated into the comprehensive primary care service which had been recently redeveloped to implement best practice care plans. The time series analysis included at least six measures prior to handover of the specialised programme and six following handover. Main outcome measures were trends in blood pressure (BP) control, and systolic and diastolic BP. We found an improvement in BP control in the first 6-12 months of the programme, followed by a steady declining trend. There was no significant difference in this trend between the pre- compared to the post-programme withdrawal period. This finding was consistent for control at levels below 130/80 and 140/90, and for trends in mean systolic and diastolic BP. Investigation of the sustainability of programme outcomes presents major challenges for research design. Sustained success in the management of chronic disease through primary care services requires better understanding of the causal mechanisms related to clinical intervention, the basis upon which they can be 'institutionalised' in a given context, and the extent to which they require regular revitalisation to maintain their effect