Nature is a rich source of medicine - if we can protect it

First paragraph: The Pacific yew tree is a fairly small and slow growing conifer native to the Pacific Northwest. The Gila monster is a lizard with striking orange and black markings from the drylands of the Southwestern US and Mexico. Two very different organisms, but with a fascinating connection. They've both given us drugs that have saved and improved the lives of millions of people. Paclitaxel, originally isolated in 1971 from the bark of the Pacific Yew tree, is so important for treating various cancers that it is one of the World Health Organisation’s "Essential Medicines". This compound has been studied in more than 3,000 clinical trials. It's safe and effective and it generates sales of around US$80-100m per year.https://theconversation.com/nature-is-a-rich-source-of-medicine-if-we-can-protect-it-10747

Designing and executing digital strategies : completed research paper

The digital economy poses existential threats to — and game-changing opportunities for — companies that were successful in the pre-digital economy. What will distinguish those companies that successfully transform from those that become historical footnotes? This is the question a group of six researchers and consultants from Boston Consulting Group set out to examine. The team conducted in-depth interviews with senior executives at twenty-seven companies in different industries to explore the strategies and organizational initiatives they relied on to seize the opportunities associated with new, readily accessible digital technologies. This paper summarizes findings from this research and offers recommendations to business leaders responsible for digital business success

Measuring the Reliability of Hate Speech Annotations: The Case of the European Refugee Crisis

Some users of social media are spreading racist, sexist, and otherwise hateful content. For the purpose of training a hate speech detection system, the reliability of the annotations is crucial, but there is no universally agreed-upon definition. We collected potentially hateful messages and asked two groups of internet users to determine whether they were hate speech or not, whether they should be banned or not and to rate their degree of offensiveness. One of the groups was shown a definition prior to completing the survey. We aimed to assess whether hate speech can be annotated reliably, and the extent to which existing definitions are in accordance with subjective ratings. Our results indicate that showing users a definition caused them to partially align their own opinion with the definition but did not improve reliability, which was very low overall. We conclude that the presence of hate speech should perhaps not be considered a binary yes-or-no decision, and raters need more detailed instructions for the annotation

Designing and Executing Digital Strategies

The digital economy poses existential threats to—and game-changing opportunities for—companies that were successful in the pre-digital economy. What will distinguish those companies that successfully transform from those that become historical footnotes? This is the question a group of six researchers and consultants from Boston Consulting Group set out to examine. The team conducted in-depth interviews with senior executives at twenty-seven companies in different industries to explore the strategies and organizational initiatives they relied on to seize the opportunities associated with new, readily accessible digital technologies. This paper summarizes findings from this research and offers recommendations to business leaders responsible for digital business success

Horizontal Inequalities and Ethnonationalist Civil War: A Global Comparison

Contemporary research on civil war has largely dismissed the role of political and economic grievances, focusing instead on opportunities for conflict. However, these strong claims rest on questionable theoretical and empirical grounds. Whereas scholars have examined primarily the relationship between individual inequality and conflict, we argue that horizontal inequalities between politically relevant ethnic groups and states at large can promote ethnonationalist conflict. Extending the empirical scope to the entire world, this article introduces a new spatial method that combines our newly geocoded data on ethnic groups’ settlement areas with spatial wealth estimates. Based on these methodological advances, we find that, in highly unequal societies, both rich and poor groups fight more often than those groups whose wealth lies closer to the country average. Our results remain robust to a number of alternative sample definitions and specifications.</jats:p

Dynamic Impurity Redistributions in Kesterite Absorbers

Cu2ZnSn(S,Se)4 is a promising nontoxic earth-abundant solar cell absorber. To optimize the thin films for solar cell device performance, postdeposition treatments at temperatures below the crystallization temperature are normally performed, which alter the surface and bulk properties. The polycrystalline thin films contain relatively high concentrations of impurities, such as sodium, oxygen and hydrogen. During the treatments, these impurities migrate and likely agglomerate at lattice defects or interfaces. Herein, impurity redistribution after air annealing for temperatures up to 200 \ub0C and short heavy water treatments are studied. In addition, nonuniformities of the sodium distribution on a nanometer and micrometer scale are characterized by atom probe tomography and secondary ion mass spectrometry, respectively. Sodium and oxygen correlate to a greater extent after heat treatments, supporting strong binding between the two impurities. Redistributions of these impurities occur even at room temperature over longer time periods. Heavy water treatments confirm out-diffusion of sodium with more incorporation of oxygen and hydrogen. It is observed that the increased hydrogen content does not originate from the heavy water. The existence of an “ice-like” layer on top of the Cu2ZnSnS4 layer is proposed

Improving cost-efficiency of faecal genotyping:new tools for elephant species

Despite the critical need for non-invasive tools to improve monitoring of wildlife populations, especially for endangered and elusive species, faecal genetic sampling has not been adopted as regular practice, largely because of the associated technical challenges and cost. Substantial work needs to be undertaken to refine sample collection and preparation methods in order to improve sample set quality and provide cost-efficient tools that can effectively support wildlife management. In this study, we collected an extensive set of forest elephant (Loxodonta cyclotis) faecal samples throughout Gabon, Central Africa, and prepared them for genotyping using 107 single-nucleotide polymorphism assays. We developed a new quantitative polymerase chain reaction (PCR) assay targeting a 130-bp nuclear DNA fragment and demonstrated its suitability for degraded samples in all three elephant species. Using this assay to compare the efficacy of two sampling methods for faecal DNA recovery, we found that sampling the whole surface of a dung pile with a swab stored in a small tube of lysis buffer was a convenient method producing high extraction success and DNA yield. We modelled the influence of faecal quality and storage time on DNA concentration in order to provide recommendations for optimized collection and storage. The maximum storage time to ensure 75% success was two months for samples collected within 24 hours after defecation and extended to four months for samples collected within one hour. Lastly, the real-time quantitative PCR assay allowed us to predict genotyping success and pre-screen DNA samples, thus further increasing the cost-efficiency of our approach. We recommend combining the validation of an efficient sampling method, the build of in-country DNA extraction capacity for reduced storage time and the development of species-specific quantitative PCR assays in order to increase the cost-efficiency of routine non-invasive DNA analyses and expand the use of next-generation markers to non-invasive samples

La naturaleza es un filón para obtener medicinas, pero solo si la protegemos

First paragraph: El Taxus brevifolia, comúnmente conocido como Tejo del Pacífico, es una conífera de tamaño reducido y de crecimiento lento originaria del Pacífico Noroeste. El monstruo de Gila es un lagarto que tiene unas llamativas marcas naranjas y negras que habita las áridas tierras del suroeste de Estados Unidos y México. Son dos organismos muy diferentes pero que comparten una conexión fascinante. Ambos nos han proporcionado medicamentos que han salvado y mejorado las vidas de millones de personas.Translation of Piper R, Kagansky A, Malone J, Bunnefeld N & Jenkins R (2018) Nature is a rich source of medicine - if we can protect it. The Conversation, 13.12.2018. https://theconversation.com/nature-is-a-rich-source-of-medicine-if-we-can-protect-it-107471 https://theconversation.com/la-naturaleza-es-un-filon-para-obtener-medicinas-pero-solo-si-la-protegemos-10893