Feasibility and beneficial effects of an early goal directed therapy after cardiac arrest: evaluation by conductance method

Although beneficial effects of an early goal directed therapy (EGDT) after cardiac arrest and successful return of spontaneous circulation (ROSC) have been described, clinical implementation in this period seems rather difficult. The aim of the present study was to investigate the feasibility and the impact of EGDT on myocardial damage and function after cardiac resuscitation. A translational pig model which has been carefully adapted to the clinical setting was employed. After 8 min of cardiac arrest and successful ROSC, pigs were randomized to receive either EGDT (EGDT group) or therapy by random computer-controlled hemodynamic thresholds (noEGDT group). Therapeutic algorithms included blood gas analysis, conductance catheter method, thermodilution cardiac output and transesophageal echocardiography. Twenty-one animals achieved successful ROSC of which 13 pigs survived the whole experimental period and could be included into final analysis. cTnT and LDH concentrations were lower in the EGDT group without reaching statistical significance. Comparison of lactate concentrations between 1 and 8 h after ROSC exhibited a decrease to nearly baseline levels within the EGDT group (1 h vs 8 h: 7.9 vs. 1.7 mmol/l, P < 0.01), while in the noEGDT group lactate concentrations did not significantly decrease. The EGDT group revealed a higher initial need for fluids (P < 0.05) and less epinephrine administration (P < 0.05) post ROSC. Conductance method determined significant higher values for preload recruitable stroke work, ejection fraction and maximum rate of pressure change in the ventricle for the EGDT group. EGDT after cardiac arrest is associated with a significant decrease of lactate levels to nearly baseline and is able to improve systolic myocardial function. Although the results of our study suggest that implementation of an EGDT algorithm for post cardiac arrest care seems feasible, the impact and implementation of EGDT algorithms after cardiac arrest need to be further investigated

Michael Koppel Fraenkel.

Two typescripts and accompanying photocopies of original documents with the biography of Michael Koppel Fränkel, born 1726, and the Josephthal family from Ansbach, Germany.digitizedLazarus-Josephthal Family history starting 1638. Family Tree Fraenkel (Fellheimer)

Heimatgeschichte der badischen Juden seit ihrem geschichtlichen Auftreten bis zur Gegenwart

von Berthold Rosenthal. Mit e. Urkundennachbildung, 10 Lichtbild. u. e. Geschichtskt. von BadenLiteraturangabe

[Stammbaum Moll].

Manuscript narrating the Moll family's history based on an extended, 3-page family tree.Bibliography : pages 47-48The family tree reaching back to 1516 is part of the paper collection in the oversize folder OS 46.additional family tree since 1570

Berthold Rosenthal Family Collection. 1875-1957 bulk: 1912-1984

The Berthold Rosenthal Collection documents the life of Berthold Rosenthal and his family, starting in 1940, the year of Berthold and Johanna Rosenthal’s immigration to the U.S. The papers of this collection are largely comprised of personal correspondence between the part of the family living in the U.S. (Berthold, his wife Johanna and their two daughters) and Berthold’s son, Ernst, who lived on a Kibbutz in Palestine/Israel. The letters are predominantly a mixture of information on familial happenings, such as marriages and the birth of children as well as of intense discussions on political events which frequently affected the parents’ lives in the U.S. and Ernst’s life in Israel directly. In addition, the collection contains articles on Berthold Rosenthal’s biography and works as well as family trees.Berthold Rosenthal was born on January 17, 1875 in Liedolsheim bei Karlsruhe, the son of Emanuel Rosenthal, a cattle dealer and Babette née Weil. In 1914 he married Johanna née Benzian. In the following years they had three children: Ernst, Ruth, and Lotte.1889-1891 Rosenthal attended preparatory school in Tauberbischofsheim. For the following three years he studied towards his teaching degree (Baden-Würtemberg). After receiving his teaching degree in Karlsruhe, he taught Jewish religion classes before moving on to a ‘Gymnasium’ in Mannheim. From 1914-1916 Rosenthal served in World War I. He was released from service because of an eye injury. He resumed teaching in Mannheim, where he continued until forced to leave in 1933. In addition to teaching, he wrote for the Jewish magazine Die neue Volksschulwarte. He was also involved in Jewish charity organizations and collected information on Jews in Baden; in 1927 his work Heimatgeschichte der badischen Juden was published. This work would become very important in the future, since it contained much information on Jews in Baden lost under the National Socialist regime. After he lost his teaching position in 1933, he conducted research and contributed articles to the Germania Judaica, a work focusing on the history of Jews in Germany. [In 1934 the Germania Judaica was stopped from being published by the German government, but was eventually published by the Leo Baeck Institute in 1968.]In September 1940 Berthold Rosenthal and his wife Johanna escaped to the United States via Portugal. They arrived in New York and were greeted by Berthold Rosenthal’s two daughters and younger siblings, who had left Germany earlier. His eldest son Ernst went to live in Palestine on a kibbutz. Berthold Rosenthal lived for eight years in New York, staying with his daughters and working in an export business owned by a relative. Eventually, Berthold Rosenthal moved to Omaha, Nebraska, where he died on December 16, 1957.Ruth FeistMemoirs of Berthold Rosenthal have been removed to the Memoir CollectionSee also the Berthold Rosenthal Collection, AR 637digitize

Hinter der grossen Armee : Ein Familienbriefwechsel /

Exchange of letters 1812-1813 between Herz Weil and his wife Vogel; contains information on Jews in Napoleonic army, Jewish cattle dealers and rural Jewish life; German translation from original West Yiddish.Herz Weil from Otterstadt (Palatine) was a cattle dealer who joined the French army during the Napoleonic Wars. He moved to Elbing (Prussia) where he served as a slaughterer for the French army.Berthold Rosenthal (Liedolsheim/Baden 1875 - Omaha/USA 1975) was a teacher at the Jewish school in Mannheim and a historian of Baden Jewry. He immigrated to the USA in 1940 (ME 529).Brief summary in Max Kreutzberger: "Leo Baeck Institute New York, Bibliothek und Archiv; Katalog": C 438PalatinateElbingPrussiaProfessions and occupations; slaughterersBadenMannhei