Dietary supplementation of essential oils in dairy cows: evidence for stimulatory effects on nutrient absorption

Results of recent in vitro experiments suggest that essential oils (EO) may not only influence ruminal fermentation but also modulate the absorption of cations like Na+, Ca2+ and NH4+ across ruminal epithelia of cattle and sheep through direct interaction with epithelial transport proteins, such as those of the transient receptor potential family. The aim of the current study was to examine this hypothesis by testing the effect of a blend of essential oils (BEO) on cation status and feed efficiency in lactating dairy cows. In the experiment, 72 dairy cows in mid-to-end lactation were divided into two groups of 36 animals each and fed the same mixed ration with or without addition of BEO in a 2×2 cross-over design. Feed intake, milk yield and composition, plasma and urine samples were monitored. Feeding BEO elevated milk yield, milk fat and protein yield as well as feed efficiency, whereas urea levels in plasma and milk decreased. In addition, plasma calcium levels increased significantly upon BEO supplementation, supporting the hypothesis that enhanced cation absorption might contribute to the beneficial effects of these EO

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells1. Whereas dynamics of epithelial stem cells during homeostasis are increasingly well understood, how stem cells are redirected from a tissue-maintenance program to initiate repair after injury remains unclear. Here we examined infection by Heligmosomoides polygyrus, a co-evolved pathosymbiont of mice, to assess the epithelial response to disruption of the mucosal barrier. H. polygyrus disrupts tissue integrity by penetrating the duodenal mucosa, where it develops while surrounded by a multicellular granulomatous infiltrate2. Crypts overlying larvae-associated granulomas did not express intestinal stem cell markers, including Lgr53, in spite of continued epithelial proliferation. Granuloma-associated Lgr5- crypt epithelium activated an interferon-gamma (IFN-γ)-dependent transcriptional program, highlighted by Sca-1 expression, and IFN-γ-producing immune cells were found in granulomas. A similar epithelial response accompanied systemic activation of immune cells, intestinal irradiation, or ablation of Lgr5+ intestinal stem cells. When cultured in vitro, granuloma-associated crypt cells formed spheroids similar to those formed by fetal epithelium, and a sub-population of H. polygyrus-induced cells activated a fetal-like transcriptional program, demonstrating that adult intestinal tissues can repurpose aspects of fetal development. Therefore, re-initiation of the developmental program represents a fundamental mechanism by which the intestinal crypt can remodel itself to sustain function after injury

A Method to Estimate the Boson Mass and to Optimise Sensitivity to Helicity Correlations of tau+tau- Final States

In proton-proton collisions at LHC energies, Z and low mass Higgs bosons would be produced with high and predominantly longitudinal boost with respect to the beam axis. This note describes a new analysis tool devised to handle this situation in cases when such bosons decay to a pair of tau-leptons. The tool reconstructs the rest frame of the tau+tau- pair by finding the boost that minimises the acollinearity between the visible tau decay products. In most cases this gives a reasonable approximation to the rest frame of the decaying boson. It is shown how the reconstructed rest frame allows for a new method of mass estimation. Also a considerable gain in sensitivity to helicity correlations is obtained by analysing the tau-jets in the reconstructed frame instead of using the laboratory momenta and energies, particularly when both tau-leptons decay hadronically.Comment: 13 pages, method extended with 3D boost finde

Avalanche statistics of sand heaps

Large scale computer simulations are presented to investigate the avalanche statistics of sand piles using molecular dynamics. We could show that different methods of measurement lead to contradicting conclusions, presumably due to avalanches not reaching the end of the experimental table.Comment: 6 pages, 4 figure

Word Processors with Line-Wrap: Cascading, Self-Organized Criticality, Random Walks, Diffusion, Predictability

We examine the line-wrap feature of text processors and show that adding characters to previously formatted lines leads to the cascading of words to subsequent lines and forms a state of self-organized criticality. We show the connection to one-dimensional random walks and diffusion problems, and we examine the predictability of catastrophic cascades.Comment: 6 pages, LaTeX with RevTeX package, 4 postscript figures appende

Self-organized criticality in a rice-pile model

We present a new model for relaxations in piles of granular material. The relaxations are determined by a stochastic rule which models the effect of friction between the grains. We find power-law distributions for avalanche sizes and lifetimes characterized by the exponents $\tau = 1.53 \pm 0.05$ and $y = 1.84 \pm 0.05$, respectively. For the discharge events, we find a characteristic size that scales with the system size as $L^\mu$, with $\mu = 1.20 \pm 0.05$. We also find that the frequency of the discharge events decrease with the system size as $L^{-\mu'}$ with $\mu' = 1.20 \pm 0.05$.Comment: 4 pages, RevTex, multicol, epsf, rotate (sty files provided). To appear Phys. Rev. E Rapid Communication (Nov or Dec 96

Anomalous Transport in Conical Granular Piles

Experiments on 2+1-dimensional piles of elongated particles are performed. Comparison with previous experiments in 1+1 dimensions shows that the addition of one extra dimension to the dynamics changes completely the avalanche properties, appearing a characteristic avalanche size. Nevertheless, the time single grains need to cross the whole pile varies smoothly between several orders of magnitude, from a few seconds to more than 100 hours. This behavior is described by a power-law distribution, signaling the existence of scale invariance in the transport process.Comment: Accepted in PR