674 research outputs found
Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4<sup>+</sup> T-cell responses
Observations of quasi-periodic solar X-ray emission as a result of MHD oscillations in a system of multiple flare loops
We investigate the solar flare of 20 October 2002. The flare was accompanied
by quasi-periodic pulsations (QPP) of both thermal and nonthermal hard X-ray
emissions (HXR) observed by RHESSI in the 3-50 keV energy range. Analysis of
the HXR time profiles in different energy channels made with the Lomb
periodogram indicates two statistically significant time periods of about 16
and 36 seconds. The 36-second QPP were observed only in the nonthermal HXR
emission in the impulsive phase of the flare. The 16-second QPP were more
pronounced in the thermal HXR emission and were observed both in the impulsive
and in the decay phases of the flare. Imaging analysis of the flare region, the
determined time periods of the QPP and the estimated physical parameters of
magnetic loops in the flare region allow us to interpret the observations as
follows. 1) In the impulsive phase energy was released and electrons were
accelerated by successive acts with the average time period of about 36 seconds
in different parts of two spatially separated, but interacting loop systems of
the flare region. 2) The 36-second periodicity of energy release could be
caused by the action of fast MHD oscillations in the loops connecting these
flaring sites. 3) During the first explosive acts of energy release the MHD
oscillations (most probably the sausage mode) with time period of 16 seconds
were excited in one system of the flare loops. 4) These oscillations were
maintained by the subsequent explosive acts of energy release in the impulsive
phase and were completely damped in the decay phase of the flare.Comment: 14 pages, 4 figure
Electromagnetic Polarization Effects due to Axion Photon Mixing
We investigate the effect of axions on the polarization of electromagnetic
waves as they propagate through astronomical distances. We analyze the change
in the dispersion of the electromagnetic wave due to its mixing with axions. We
find that this leads to a shift in polarization and turns out to be the
dominant effect for a wide range of frequencies. We analyze whether this effect
or the decay of photons into axions can explain the large scale anisotropies
which have been observed in the polarizations of quasars and radio galaxies. We
also comment on the possibility that the axion-photon mixing can explain the
dimming of distant supernovae.Comment: 18 pages, 1 figur
Cosmology at the Millennium
One hundred years ago we did not know how stars generate energy, the age of
the Universe was thought to be only millions of years, and our Milky Way galaxy
was the only galaxy known. Today, we know that we live in an evolving and
expanding Universe comprising billions of galaxies, all held together by dark
matter. With the hot big-bang model, we can trace the evolution of the Universe
from the hot soup of quarks and leptons that existed a fraction of a second
after the beginning to the formation of galaxies a few billion years later, and
finally to the Universe we see today 13 billion years after the big bang, with
its clusters of galaxies, superclusters, voids, and great walls. The attractive
force of gravity acting on tiny primeval inhomogeneities in the distribution of
matter gave rise to all the structure seen today. A paradigm based upon deep
connections between cosmology and elementary particle physics -- inflation +
cold dark matter -- holds the promise of extending our understanding to an even
more fundamental level and much earlier times, as well as shedding light on the
unification of the forces and particles of nature. As we enter the 21st
century, a flood of observations is testing this paradigm.Comment: 44 pages LaTeX with 14 eps figures. To be published in the Centennial
Volume of Reviews of Modern Physic
Feasibility and Acceptability of Conducting a Randomized Clinical Trial Designed to Improve Interpretation of Screening Mammography
To describe recruitment, enrollment and participation in a study of U.S. radiologists invited to participate in a randomized controlled trial of two continuing medical education interventions designed to improve interpretation of screening mammography
Association Between Time Spent Interpreting, Level of Confidence, and Accuracy of Screening Mammography
To examine the effect of time spent viewing images and level of confidence on a screening mammography test set on interpretive performance
Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: Clinical and therapeutic implications
Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation. sJIA is distinguished from other forms of JIA by unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half of children with sJIA develop destructive, long-standing arthritis that appears similar to other forms of JIA. Using genomic approaches, we sought to gain novel insights into the pathophysiology of sJIA and its relationship with other forms of JIA. Methods We performed a genome-wide association study of 770 children with sJIA collected in nine countries by the International Childhood Arthritis Genetics Consortium. Single nucleotide polymorphisms were tested for association with sJIA. Weighted genetic risk scores were used to compare the genetic architecture of sJIA with other JIA subtypes. Results The major histocompatibility complex locus and a locus on chromosome 1 each showed association with sJIA exceeding the threshold for genome-wide significance, while 23 other novel loci were suggestive of association with sJIA. Using a combination of genetic and statistical approaches, we found no evidence of shared genetic architecture between sJIA and other common JIA subtypes. Conclusions The lack of shared genetic risk factors between sJIA and other JIA subtypes supports the hypothesis that sJIA is a unique disease process and argues for a different classification framework. Research to improve sJIA therapy should target its unique genetics and specific pathophysiological pathways
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Intrauterine devices and endometrial cancer risk : a pooled analysis of the Epidemiology of Endometrial Cancer Consortium
Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-ORâ=â0.81, 95% CIâ=â0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-ORâ=â0.69, 95% CIâ=â0.58-0.82), older age at first use (â„35 years pooled-ORâ=â0.53, 95% CIâ=â0.43-0.67), older age at last use (â„45 years pooled-ORâ=â0.60, 95% CIâ=â0.50-0.72), longer duration of use (â„10 years pooled-ORâ=â0.61, 95% CIâ=â0.52-0.71) and recent use (within 1 year of study entry pooled-ORâ=â0.39, 95% CIâ=â0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes
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