Recorridos

The story of don Quixote is perfect to promote authentic communication and critical thinking in the upper level Spanish classroom. A companion Teacher Support is available. The language of the Siglo de Oro can be an insurmountable barrier for many readers. This textbook provides historical information, narrative techniques, lists of characters, themes and key words before they begin to read each chapter. While reading, vocabulary glossed in comprehensible Spanish appears in the margin opposite challenging words. Cultural references and proverbs from the work facilitate a deeper understanding. Each chapter contains checks for understanding and ends with activities to build vocabulary. It includes chapters 1-8, 10, 17 and 74 for AP classrooms.Center for Open Educational Resources and Language Learnin

Simulation of Laser Beam Propagation With a Paraxial Model in a Tilted Frame

We study the Schr\"odinger equation which comes from the paraxial approximation of the Helmholtz equation in the case where the direction of propagation is tilted with respect to the boundary of the domain. In a first part, a mathematical analysis is made which leads to an analytical formula of the solution in the simple case where the refraction index and the absorption coefficients are constant. Afterwards, we propose a numerical method for solving the initial problem which uses the previous analytical expression. Numerical results are presented. We also sketch an extension to a time dependant model which is relevant for laser plasma interaction

Transforming pedagogies: Encouraging pre-service teachers to engage the power of the arts in their approach to teaching and learning

This paper describes and analyses, through the use of case studies, two experiences of transformative learning in an undergraduate arts education unit. Pre-service teachers designed and engaged with arts-based curriculum activities, created their own artwork, participated in a modified production of The Tempest and kept a reflective journal. These activities constituted the data which was analysed using creative frameworks such as case writing, script writing, narrative analysis and found poetry as ways of developing richer understanding of pre-service teachers’ self-perceptions and self-awareness as teachers and as potential artists. The stories explored here uncover two different ways of encountering the challenges of learning - resistance and struggle - and highlight the significance of the educator’s response to individual student needs, and the value of reflective skills in shifting pre-service teachers’ cultural, political and institutional understandings

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain

Although extensively investigated, cancer is still one of the most devastating and lethal diseases in the modern world. Among different types, colorectal cancer (CRC) is most prevalent and mortal, making it an important subject of research. The metalloprotease ADAM17 has been implicated in the development of CRC due to its involvement in signaling pathways related to inflammation and cell proliferation. ADAM17 is capable of releasing membrane-bound proteins from the cell surface in a process called shedding. A deficiency of ADAM17 activity has been previously shown to have protective effects against CRC in mice, while an upregulation of ADAM17 activity is suspected to facilitate tumor development. In this study, we characterize ADAM17 variants found in tissue samples of cancer patients in overexpression studies. We here focus on point mutations identified within the catalytic domain of ADAM17 and could show a functional dysregulation of the CRC-associated variants. Since the catalytic domain of ADAM17 is the only region structurally determined by crystallography, we study the effect of each point mutation not only to learn more about the role of ADAM17 in cancer, but also to investigate the structure-function relationships of the metalloprotease