Sons of the Gods, Children of Earth

In this ambitious and venturesome book, Peter W. Rose applies the insights of Marxist theory to a number of central Greek literary and philosophical texts. He explores major points in the trajectory from Homer to Plato where the ideology of inherited excellence—beliefs about descent from gods or heroes—is elaborated and challenged. Rose offers subtle and penetrating new readings of Homer's Iliad and Odyssey, Pindar's Tenth Pythian Ode, Aeschylus's Oresteia, Sophokles' Philoktetes, and Plato's Republic.Rose rejects the view of art as a mere reflection of social and political reality—a view that is characteristic not only of most Marxist but of most historically oriented treatments of classical literature. He applies instead a Marxian hermeneutic derived from the work of the Frankfurt School and Fredric Jameson. His readings focus on illuminating a politics of form within the text, while responding to historically specific social, political, and economic realities. Each work, he asserts, both reflects contemporary conflicts over wealth, power, and gender roles and constitutes an attempt to transcend the status quo by projecting an ideal community. Following Marx, Rose maintains that critical engagement with the limitations of the utopian dreams of the past is the only means to the realization of freedom in the present.Classicists and their students, literary theorists, philosophers, comparatists, and Marxist critics will find Sons of the Gods, Children of Earth challenging reading.In this ambitious and venturesome book, Peter W. Rose applies the insights of Marxist theory to a number of central Greek literary and philosophical texts. He explores major points in the trajectory from Homer to Plato where the ideology of inherited excellence—beliefs about descent from gods or heroes—is elaborated and challenged. Rose offers subtle and penetrating new readings of Homer's Iliad and Odyssey, Pindar's Tenth Pythian Ode, Aeschylus's Oresteia, Sophokles' Philoktetes, and Plato's Republic.Rose rejects the view of art as a mere reflection of social and political reality—a view that is characteristic not only of most Marxist but of most historically oriented treatments of classical literature. He applies instead a Marxian hermeneutic derived from the work of the Frankfurt School and Fredric Jameson. His readings focus on illuminating a politics of form within the text, while responding to historically specific social, political, and economic realities. Each work, he asserts, both reflects contemporary conflicts over wealth, power, and gender roles and constitutes an attempt to transcend the status quo by projecting an ideal community. Following Marx, Rose maintains that critical engagement with the limitations of the utopian dreams of the past is the only means to the realization of freedom in the present.Classicists and their students, literary theorists, philosophers, comparatists, and Marxist critics will find Sons of the Gods, Children of Earth challenging reading

Ten Simple Rules for Reproducible Research in Jupyter Notebooks

Reproducibility of computational studies is a hallmark of scientific methodology. It enables researchers to build with confidence on the methods and findings of others, reuse and extend computational pipelines, and thereby drive scientific progress. Since many experimental studies rely on computational analyses, biologists need guidance on how to set up and document reproducible data analyses or simulations. In this paper, we address several questions about reproducibility. For example, what are the technical and non-technical barriers to reproducible computational studies? What opportunities and challenges do computational notebooks offer to overcome some of these barriers? What tools are available and how can they be used effectively? We have developed a set of rules to serve as a guide to scientists with a specific focus on computational notebook systems, such as Jupyter Notebooks, which have become a tool of choice for many applications. Notebooks combine detailed workflows with narrative text and visualization of results. Combined with software repositories and open source licensing, notebooks are powerful tools for transparent, collaborative, reproducible, and reusable data analyses

Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm

Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. In addition to the accurate detection of internal symmetry, the tool is now capable of i) reporting the type of symmetry, ii) identifying the smallest repeating unit, iii) describing the arrangement of repeats with transformation operations and symmetry axes, and iv) comparing the similarity of all the internal repeats at the residue level. CE-Symm 2.0 helps the user investigate proteins with a robust and intuitive sequence-to-structure analysis, with many applications in protein classification, functional annotation and evolutionary studies. We describe the algorithmic extensions of the method and demonstrate its applications to the study of interesting cases of protein evolution

Effects of foam on ocean surface microwave emission inferred from radiometric observations of reproducible breaking waves

Includes bibliographical references.WindSat, the first satellite polarimetric microwave radiometer, and the NPOESS Conical Microwave Imager/Sounder both have as a key objective the retrieval of the ocean surface wind vector from radiometric brightness temperatures. Available observations and models to date show that the wind direction signal is only 1-3 K peak-to-peak at 19 and 37 GHz, much smaller than the wind speed signal. In order to obtain sufficient accuracy for reliable wind direction retrieval, uncertainties in geophysical modeling of the sea surface emission on the order of 0.2 K need to be removed. The surface roughness spectrum has been addressed by many studies, but the azimuthal signature of the microwave emission from breaking waves and foam has not been adequately addressed. RECENtly, a number of experiments have been conducted to quantify the increase in sea surface microwave emission due to foam. Measurements from the Floating Instrumentation Platform indicated that the increase in ocean surface emission due to breaking waves may depend on the incidence and azimuth angles of observation. The need to quantify this dependence motivated systematic measurement of the microwave emission from reproducible breaking waves as a function of incidence and azimuth angles. A number of empirical parameterizations of whitecap coverage with wind speed were used to estimate the increase in brightness temperatures measured by a satellite microwave radiometer due to wave breaking in the field of view. These results provide the first empirically based parameterization with wind speed of the effect of breaking waves and foam on satellite brightness temperatures at 10.8, 19, and 37 GHz.This work was supported in part by the Department of the Navy, Office of Naval Research under Awards N00014-00-1-0615 (ONR/YIP) and N00014-03-1-0044 (Space and Remote Sensing) to the University of Massachusetts Amherst, and N00014-00-1-0152 (Space and Remote Sensing) to the University of Washington. The National Polar-orbiting Operational environmental Satellite System Integrated Program Office supported the Naval Research Laboratory's participation through Award NA02AANEG0338 and supported data analysis at Colorado State University and the University of Washington through Award NA05AANEG0153

XMM-Newton observations of the eastern jet of SS433

The radio supernova remnant W50 hosts at its center the peculiar galactic X-ray binary SS 433. It shows a central spherical structure with two `ears' which are supposed to be formed by the interaction of the precessing jets of SS 433 with the supernova shell. In two pointings in September/October 2004 for 30 ks each the eastern jet of SS 433 was observed with XMM-Newton to study the outermost parts of the `ear' and the X-ray bright emission region about 35 arcmin from SS 433. The spectra consist of two components: a non-thermal power law with photon index \Gamma ~ 2.17+/-0.02 and a thermal component at a typical temperature of kT ~ 0.3 keV. The X-ray emission seems to fill the whole interior region of the radio remnant W50. The jet terminates in the eastern `ear' in a ring-like terminal shock which indicates a flow with a kind of hollow-cone morphology. The spatial coincidence of X-ray and radio emission suggests physical conditions similar to those found at the outer shocks of ordinary supernova remnants. The bright emission region closer to SS 433 radiates non-thermally in a spatially well confined geometry at higher X-ray energies. At soft X-rays the shape of the region gets blurred, centered on the hard lenticular emission. The shape of this region and the bend in the jet propagation direction might be caused by the interaction of a re-collimated jet with the outer, non homogeneous interstellar matter distribution. The physical conditions leading to the re-collimation of the jet and the peculiar emission morphology are far from being understood and require deeper observations as well as a detailed modeling of the interaction of a jet with its surroundings.Comment: 10 pages, 8 figures, to appear in A&

GPs’ understanding and practice of safety netting for potential cancer presentations : a qualitative study in primary care

Background Safety netting is a diagnostic strategy used in UK primary care to ensure patients are monitored until their symptoms or signs are explained. Despite being recommended in cancer diagnosis guidelines, little evidence exists about which components are effective and feasible in modern-day primary care. Aim To understand the reality of safety netting for cancer in contemporary primary care. Design and setting A qualitative study of GPs in Oxfordshire primary care. Method In-depth interviews with a purposive sample of 25 qualified GPs were undertaken. Interviews were recorded and transcribed verbatim, and analysed thematically using constant comparison. Results GPs revealed uncertainty about which aspects of clinical practice are considered safety netting. They use bespoke personal strategies, often developed from past mistakes, without knowledge of their colleagues’ practice. Safety netting varied according to the perceived risk of cancer, the perceived reliability of each patient to follow advice, GP working patterns, and time pressures. Increasing workload, short appointments, and a reluctance to overburden hospital systems or create unnecessary patient anxiety have together led to a strategy of selective active follow-up of patients perceived to be at higher risk of cancer or less able to act autonomously. This left patients with low-risk-but-not-no-risk symptoms of cancer with less robust or absent safety netting. Conclusion GPs would benefit from clearer guidance on which aspects of clinical practice contribute to effective safety netting for cancer. Practice systems that enable active follow-up of patients with low-risk-but-not-no-risk symptoms, which could represent malignancy, could reduce delays in cancer diagnosis without increasing GP workload