Mental Health in the African American Community and the Impact of Historical Trauma: Systematic Barriers

African Americans are overrepresented in high-risk populations and are known to experience disadvantages in mental health services. In an effort to better understand the barriers that prevent African Americans from receiving adequate mental health services; this study explores barriers on multiple system levels and the implications for clinical practice. This study also explores the relevance and impact of historical trauma. Qualitative interviews were used to collect the experiences of African American clinicians in the mental health field working with African American clients. Findings revealed twelve themes that are consistent with previous research. These themes are; historical trauma, stigma, cultural stereotypes, cultural mistrust, informal support, lack of African American professionals, cultural competency, issues in assessment, misdiagnosis, cultural paranoia, treatment, and economic inequality. These themes show the systematic issues that prevent African Americans from seeking and receiving adequate mental health services. Implications for clinical practice and opportunities for change are discussed

The Adolescent Female\u27s Lived-Experience of Obesity

For adolescent girls, negative messages about obesity and body image from society, media, school, family, and peers are plentiful. Yet the lived-experience of obese adolescent girls has rarely been reported in scientific literature. The purpose of this study was to explore the lived-experience of the obese adolescent female and understand the impact of the messages received. A descriptive phenomenological approach was used to conduct face-to-face interviews with eight adolescent girls, age 11-18. Participants were recruited through network sampling and had a body mass index of 30 or more. Merleau-Ponty’s philosophy of embodied perception guided interpretation and data analysis. Seven themes describe their lived experience and reflect the internal and external messages perceived including, false assumptions, myth of perfection, nonculpable diversity, nobody’s perfect, beauty is not skin deep, disengagement, and society’s misplaced focus. Awareness of the livedexperience described in these themes, may guide health care providers to formulate a holistic plan of care that will positively impact both the physical and psychosocial health of the adolescent female who is obese

The Role of Parenting Social Support, Religious Coping, and Religious Practices in Moderating the Effects of Financial Poverty on Symptoms of Depression Among Rural, Low-Income Mothers

This study explored relationships between financial poverty, social support, religious coping, religious practices, and symptoms of depression among rural, low-income mothers. Given the higher incidence of depression in these impoverished mothers and the limited mental health services in rural areas, this study sought to identify factors that are protective against depression. While research suggests that social support, religious coping and religious practices are protective against depression, there has been little research exploring these relationships among rural, low-income mothers. Correlations, t-tests, and hierarchical multiple regressions were utilized. The findings did not support the hypotheses that social support, religious coping, and religious practices functioned as moderators. However, for all mothers the higher the perception of economic situation and income adequacy, parenting social support, and religious practices, the lower the symptoms of depression. Additionally, for minority mothers the higher the religious coping, the lower the symptoms of depression. Recommendations for future research and psychotherapy are discussed

Training neural network ensembles via trajectory sampling

In machine learning, there is renewed interest in neural network ensembles (NNEs), whereby predictions are obtained as an aggregate from a diverse set of smaller models, rather than from a single larger model. Here, we show how to define and train a NNE using techniques from the study of rare trajectories in stochastic systems. We define an NNE in terms of the trajectory of the model parameters under a simple, and discrete in time, diffusive dynamics, and train the NNE by biasing these trajectories towards a small time-integrated loss, as controlled by appropriate counting fields which act as hyperparameters. We demonstrate the viability of this technique on a range of simple supervised learning tasks. We discuss potential advantages of our trajectory sampling approach compared with more conventional gradient based methods.Comment: 12 pages, 5 figures, 1 appendi

Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells

The P-glycoprotein efflux system located on the apical membrane of brain capillary endothelial cells functions as part of the blood-brain barrier. In this study, primary cultures of bovine brain microvessel endothelial cells (BMECs) were investigated for the presence of a P-glycoprotein system and its contribution in regulating ivermectin distribution across the blood-brain barrier. Results of rhodamine 123 uptake studies with cyclosporin A and verapamil as substrates indicated that a functional efflux system was present on BMECs. Immunoblot analysis with the C219 monoclonal antibody to the product of the multidrug resistant member 1(MDR1) gene also confirmed the expression of MDR1 in the BMECs. Unbound ivermectin was shown to significantly increase the uptake of rhodamine 123 in BMECs, however, the drug only modestly enhanced the transcellular passage of rhodamine. The results of these studies affirmed that unbound ivermectin is an inhibitor of the MDR1 efflux system in BMECs

Promising Practices and Unfinished Business: Fostering Equity and Excellence for Black and Latino Males

Boston Public Schools (BPS) commissioned companion studies as part of its efforts to address achievement gaps for Black and Latino males. The first study revealed the increasing diversity of Black and Latino males and stark opportunity gaps throughout the system that contribute in large part to wide attainment gaps for these students. We hypothesized that in schools doing comparatively better with Black or Latino males than their counterparts, educators would be strategically and comprehensively implementing evidence-based cultural, structural, and instructional practices tailored to meet their the needs and aspirations of these students. Through qualitative case studies of four schools, we identified several cross-cutting themes that provide the district and school leaders with some positive news about effective practices found in all good schools: strong school cultures, professional collaboration, differentiated instruction, and, in the elementary schools, family engagement. While we observed pockets of best practices specific to Black and Latino male education, we also brought to light unfinished business, in that none of the four case study schools had an intentional and comprehensive schoolwide approach to educating Black and Latino males. This lack of intentionality resulted in a paucity of evidence that the school administration and faculty as a whole: (a) know and value students' cultural and linguistic backgrounds; (b) adopt explicit and responsive approaches to race and gender; and (c) develop and implement a comprehensive approach to culturally responsive curriculum and instruction. We posit that lack of knowledge, intentionality, and coherence impedes further progress in educating Black and Latino males, and has implications for educators in schools, for staff members in community partner organizations, and for family members of BPS students

Sociology of low expectations: Recalibration as innovation work in biomedicine

"This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). "Social scientists have drawn attention to the role of hype and optimistic visions of the future in providing momentum to biomedical innovation projects by encouraging innovation alliances. In this article, we show how less optimistic, uncertain, and modest visions of the future can also provide innovation projects with momentum. Scholars have highlighted the need for clinicians to carefully manage the expectations of their prospective patients. Using the example of a pioneering clinical team providing deep brain stimulation to children and young people with movement disorders, we show how clinicians confront this requirement by drawing on their professional knowledge and clinical expertise to construct visions of the future with their prospective patients; visions which are personalized, modest, and tainted with uncertainty. We refer to this vision-constructing work as recalibration, and we argue that recalibration enables clinicians to manage the tension between the highly optimistic and hyped visions of the future that surround novel biomedical interventions, and the exigencies of delivering those interventions in a clinical setting. Drawing on work from science and technology studies, we suggest that recalibration enrolls patients in an innovation alliance by creating a shared understanding of how the “effectiveness” of an innovation shall be judged.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)

Everything You Need to Know about Grants: Beginning, Middle and End

“Everything You Need to Know about Grants: Beginning, Middle and End” was a 90-minute session presented at the Society of California Archivists Annual General Meeting in Berkeley, CA, on April 13, 2013. As a part of the archival community, many of us know that grants are an excellent way to reduce backlogs or accomplish projects we don\u27t have the resources to tackle. However, what many of us may not know is how much work goes into successfully implementing and completing a grant. The purpose of this session was to assemble a group of individuals who have been involved in various aspects of the grant application and implementation process to share their expertise with the archival community. The session utilized a question and answer format with a moderator asking pre-arranged questions. This article provides excerpts from the panelists’ responses